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Sequence of DOT1_YEAST

EC Number:2.1.1.360

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
[histone H3]-lysine79 N-trimethyltransferase
Q04089
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
582
66201
Reaction
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
Other sequences found for EC No. 2.1.1.360

General information:

Sequence
show sequence in fasta format
  0 MGGQESISNN NSDSFIMSSP NLDSQESSIS PIDEKKGTDM QTKSLSSYSK GTLLSKQVQN
 60 LLEEANKYDP IYGSSLPRGF LRDRNTKGKD NGLVPLVEKV IPPIHKKTNN RNTRKKSSTT
120 TKKDVKKPKA AKVKGKNGRT NHKHTPISKQ EIDTAREKKP LKKGRANKKN DRDSPSSTFV
180 DWNGPCLRLQ YPLFDIEYLR SHEIYSGTPI QSISLRTNSP QPTSLTSDND TSSVTTAKLQ
240 SILFSNYMEE YKVDFKRSTA IYNPMSEIGK LIEYSCLVFL PSPYAEQLKE TILPDLNASF
300 DNSDTKGFVN AINLYNKMIR EIPRQRIIDH LETIDKIPRS FIHDFLHIVY TRSIHPQANK
360 LKHYKAFSNY VYGELLPNFL SDVYQQCQLK KGDTFMDLGS GVGNCVVQAA LECGCALSFG
420 CEIMDDASDL TILQYEELKK RCKLYGMRLN NVEFSLKKSF VDNNRVAELI PQCDVILVNN
480 FLFDEDLNKK VEKILQTAKV GCKIISLKSL RSLTYQINFY NVENIFNRLK VQRYDLKEDS
540 VSWTHSGGEY YISTVMEDVD ESLFSPAARG RRNRGTPVKY TR
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
26686
Singer M.S.,Kahana A.,Wolf A.J.,Meisinger L.L.,Peterson S.E.,Goggin C.,Mahowald M.,Gottschling D.E.
Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae.
Genetics
150
613-632
1998
26687
Jacq C.,Alt-Moerbe J.,Andre B.,Arnold W.,Bahr A.,Ballesta J.P.G.,Bargues M.,Baron L.,Becker A.,Biteau N.,Bloecker H.,Blugeon C.,Boskovic J.,Brandt P.,Brueckner M.,Buitrago M.J.,Coster F.,Delaveau T.,del Rey F.,Dujon B.,Eide L.G.,Garcia-Cantalejo J.M.,Goffeau A.,Gomez-Peris A.,Granotier C.,Hanemann V.,Hankeln T.,Hoheisel J.D.,Jaeger W.,Jimenez A.,Jonniaux J.-L.,Kraemer C.,Kuester H.,Laamanen P.,Legros Y.,Louis E.J.,Moeller-Rieker S.,Monnet A.,Moro M.,Mueller-Auer S.,Nussbaumer B.,Paricio N.,Paulin L.,Perea J.,Perez-Alonso M.,Perez-Ortin J.E.,Pohl T.M.,Prydz H.,Purnelle B.,Rasmussen S.W.,Remacha M.A.,Revuelta J.L.,Rieger M.,Salom D.,Saluz H.P.,Saiz J.E.,Saren A.-M.,Schaefer M.,Scharfe M.,Schmidt E.R.,Schneider C.,Scholler P.,Schwarz S.,Soler-Mira A.,Urrestarazu L.A.,Verhasselt P.,Vissers S.,Voet M.,Volckaert G.,Wagner G.,Wambutt R.,Wedler E.,Wedler H.,Woelfl S.,Harris D.E.,Bowman S.,Brown D.,Churcher C.M.,Connor R.,Dedman K.,Gentles S.,Hamlin N.,Hunt S.,Jones L.,McDonald S.,Murphy L.D.,Niblett D.,Odell C.,Oliver K.,Rajandream M.A.,Richards C.,Shore L.,Walsh S.V.,Barrell B.G.,Dietrich F.S.,Mulligan J.T.,Allen E.,Araujo R.,Aviles E.,Berno A.,Carpenter J.,Chen E.,Cherry J.M.,Chung E.,Duncan M.,Hunicke-Smith S.,Hyman R.W.,Komp C.,Lashkari D.,Lew H.,Lin D.,Mosedale D.,Nakahara K.,Namath A.,Oefner P.,Oh C.,Petel F.X.,Roberts D.,Schramm S.,Schroeder M.,Shogren T.,Shroff N.,Winant A.,Yelton M.A.,Botstein D.,Davis R.W.,Johnston M.,Andrews S.,Brinkman R.,Cooper J.,Ding H.,Du Z.,Favello A.,Fulton L.,Gattung S.,Greco T.,Hallsworth K.,Hawkins J.,Hillier L.W.,Jier M.,Johnson D.,Johnston L.,Kirsten J.,Kucaba T.,Langston Y.,Latreille P.,Le T.,Mardis E.,Menezes S.,Miller N.,Nhan M.,Pauley A.,Peluso D.,Rifkin L.,Riles L.,Taich A.,Trevaskis E.,Vignati D.,Wilcox L.,Wohldman P.,Vaudin M.,Wilson R.,Waterston R.,Albermann K.,Hani J.,Heumann K.,Kleine K.,Mewes H.-W.,Zollner A.,Zaccaria P.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Nature
387
75-78
1997
26688
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
26689
San-Segundo P.A.,Roeder G.S.
Role for the silencing protein Dot1 in meiotic checkpoint control.
Mol. Biol. Cell
11
3601-3615
2000
26690
van Leeuwen F.,Gafken P.R.,Gottschling D.E.
Dot1p modulates silencing in yeast by methylation of the nucleosome core.
Cell
109
745-756
2002
26691
Ng H.H.,Feng Q.,Wang H.,Erdjument-Bromage H.,Tempst P.,Zhang Y.,Struhl K.
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.
Genes Dev.
16
1518-1527
2002
26692
Lacoste N.,Utley R.T.,Hunter J.M.,Poirier G.G.,Cote J.
Disruptor of telomeric silencing-1 is a chromatin-specific histone H3 methyltransferase.
J. Biol. Chem.
277
30421-30424
2002
26693
Ng H.H.,Xu R.-M.,Zhang Y.,Struhl K.
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.
J. Biol. Chem.
277
34655-34657
2002
26694
Briggs S.D.,Xiao T.,Sun Z.-W.,Caldwell J.A.,Shabanowitz J.,Hunt D.F.,Allis C.D.,Strahl B.D.
Gene silencing: trans-histone regulatory pathway in chromatin.
Nature
418
498-498
2002
26695
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
26696
Ng H.H.,Ciccone D.N.,Morshead K.B.,Oettinger M.A.,Struhl K.
Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation.
Proc. Natl. Acad. Sci. U.S.A.
100
1820-1825
2003
26697
Giannattasio M.,Lazzaro F.,Plevani P.,Muzi-Falconi M.
The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1.
J. Biol. Chem.
280
9879-9886
2005
26698
Wysocki R.,Javaheri A.,Allard S.,Sha F.,Cote J.,Kron S.J.
Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.
Mol. Cell. Biol.
25
8430-8443
2005
26699
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
26700
Holt L.J.,Tuch B.B.,Villen J.,Johnson A.D.,Gygi S.P.,Morgan D.O.
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Science
325
1682-1686
2009
26701
Sawada K.,Yang Z.,Horton J.R.,Collins R.E.,Zhang X.,Cheng X.
Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase.
J. Biol. Chem.
279
43296-43306
2004