Sequence of BACE1_MOUSE

memapsin 2

P56818

501

55748

269260

Vassar R.,Bennett B.D.,Babu-Khan S.,Kahn S.,Mendiaz E.A.,Denis P.,Teplow D.B.,Ross S.,Amarante P.,Loeloff R.,Luo Y.,Fisher S.,Fuller J.,Edenson S.,Lile J.,Jarosinski M.A.,Biere A.L.,Curran E.,Burgess T.,Louis J.-C.,Collins F.,Treanor J.,Rogers G.,Citron M.

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.

Science

286

735-741

1999

269262

Yan R.,Bienkowski M.J.,Shuck M.E.,Miao H.,Tory M.C.,Pauley A.M.,Brashier J.R.,Stratman N.C.,Mathews W.R.,Buhl A.E.,Carter D.B.,Tomasselli A.G.,Parodi L.A.,Heinrikson R.L.,Gurney M.E.

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.

Nature

402

533-537

1999

269263

Carninci P.,Kasukawa T.,Katayama S.,Gough J.,Frith M.C.,Maeda N.,Oyama R.,Ravasi T.,Lenhard B.,Wells C.,Kodzius R.,Shimokawa K.,Bajic V.B.,Brenner S.E.,Batalov S.,Forrest A.R.,Zavolan M.,Davis M.J.,Wilming L.G.,Aidinis V.,Allen J.E.,Ambesi-Impiombato A.,Apweiler R.,Aturaliya R.N.,Bailey T.L.,Bansal M.,Baxter L.,Beisel K.W.,Bersano T.,Bono H.,Chalk A.M.,Chiu K.P.,Choudhary V.,Christoffels A.,Clutterbuck D.R.,Crowe M.L.,Dalla E.,Dalrymple B.P.,de Bono B.,Della Gatta G.,di Bernardo D.,Down T.,Engstrom P.,Fagiolini M.,Faulkner G.,Fletcher C.F.,Fukushima T.,Furuno M.,Futaki S.,Gariboldi M.,Georgii-Hemming P.,Gingeras T.R.,Gojobori T.,Green R.E.,Gustincich S.,Harbers M.,Hayashi Y.,Hensch T.K.,Hirokawa N.,Hill D.,Huminiecki L.,Iacono M.,Ikeo K.,Iwama A.,Ishikawa T.,Jakt M.,Kanapin A.,Katoh M.,Kawasawa Y.,Kelso J.,Kitamura H.,Kitano H.,Kollias G.,Krishnan S.P.,Kruger A.,Kummerfeld S.K.,Kurochkin I.V.,Lareau L.F.,Lazarevic D.,Lipovich L.,Liu J.,Liuni S.,McWilliam S.,Madan Babu M.,Madera M.,Marchionni L.,Matsuda H.,Matsuzawa S.,Miki H.,Mignone F.,Miyake S.,Morris K.,Mottagui-Tabar S.,Mulder N.,Nakano N.,Nakauchi H.,Ng P.,Nilsson R.,Nishiguchi S.,Nishikawa S.,Nori F.,Ohara O.,Okazaki Y.,Orlando V.,Pang K.C.,Pavan W.J.,Pavesi G.,Pesole G.,Petrovsky N.,Piazza S.,Reed J.,Reid J.F.,Ring B.Z.,Ringwald M.,Rost B.,Ruan Y.,Salzberg S.L.,Sandelin A.,Schneider C.,Schoenbach C.,Sekiguchi K.,Semple C.A.,Seno S.,Sessa L.,Sheng Y.,Shibata Y.,Shimada H.,Shimada K.,Silva D.,Sinclair B.,Sperling S.,Stupka E.,Sugiura K.,Sultana R.,Takenaka Y.,Taki K.,Tammoja K.,Tan S.L.,Tang S.,Taylor M.S.,Tegner J.,Teichmann S.A.,Ueda H.R.,van Nimwegen E.,Verardo R.,Wei C.L.,Yagi K.,Yamanishi H.,Zabarovsky E.,Zhu S.,Zimmer A.,Hide W.,Bult C.,Grimmond S.M.,Teasdale R.D.,Liu E.T.,Brusic V.,Quackenbush J.,Wahlestedt C.,Mattick J.S.,Hume D.A.,Kai C.,Sasaki D.,Tomaru Y.,Fukuda S.,Kanamori-Katayama M.,Suzuki M.,Aoki J.,Arakawa T.,Iida J.,Imamura K.,Itoh M.,Kato T.,Kawaji H.,Kawagashira N.,Kawashima T.,Kojima M.,Kondo S.,Konno H.,Nakano K.,Ninomiya N.,Nishio T.,Okada M.,Plessy C.,Shibata K.,Shiraki T.,Suzuki S.,Tagami M.,Waki K.,Watahiki A.,Okamura-Oho Y.,Suzuki H.,Kawai J.,Hayashizaki Y.

The transcriptional landscape of the mammalian genome.

Science

309

1559-1563

2005

269264

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

269266

Dominguez D.,Tournoy J.,Hartmann D.,Huth T.,Cryns K.,Deforce S.,Serneels L.,Camacho I.E.,Marjaux E.,Craessaerts K.,Roebroek A.J.M.,Schwake M.,D'Hooge R.,Bach P.,Kalinke U.,Moechars D.,Alzheimer C.,Reiss K.,Saftig P.,De Strooper B.

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.

J. Biol. Chem.

280

30797-30806

2005

269267

Spoelgen R.,von Arnim C.A.,Thomas A.V.,Peltan I.D.,Koker M.,Deng A.,Irizarry M.C.,Andersen O.M.,Willnow T.E.,Hyman B.T.

Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.

J. Neurosci.

26

418-428

2006

269268

Vetrivel K.S.,Meckler X.,Chen Y.,Nguyen P.D.,Seidah N.G.,Vassar R.,Wong P.C.,Fukata M.,Kounnas M.Z.,Thinakaran G.

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.

J. Biol. Chem.

284

3793-3803

2009

269269

Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.

A tissue-specific atlas of mouse protein phosphorylation and expression.

Cell

143

1174-1189

2010

269270

Das U.,Scott D.A.,Ganguly A.,Koo E.H.,Tang Y.,Roy S.

Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.

Neuron

79

447-460

2013

269271

Kizuka Y.,Kitazume S.,Fujinawa R.,Saito T.,Iwata N.,Saido T.C.,Nakano M.,Yamaguchi Y.,Hashimoto Y.,Staufenbiel M.,Hatsuta H.,Murayama S.,Manya H.,Endo T.,Taniguchi N.

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.

EMBO Mol. Med.

7

175-189

2015

269272

Kizuka Y.,Nakano M.,Kitazume S.,Saito T.,Saido T.C.,Taniguchi N.

Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.

Biochem. J.

473

21-30

2016

269273

Wang X.,Wang C.,Pei G.

alpha-secretase ADAM10 physically interacts with beta-secretase BACE1 in neurons and regulates CHL1 proteolysis.

J. Mol. Cell Biol.

10

411-422

2018