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Sequence of DNLI4_HUMAN

EC Number:6.5.1.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
DNA ligase (ATP)
P49917
Homo sapiens
911
103971
Reaction
(deoxyribonucleotide)n-3'-hydroxyl + 5'-(5'-diphosphoadenosine)-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP
Other sequences found for EC No. 6.5.1.1

General information:

Sequence
show sequence in fasta format
  0 MAASQTSQTV ASHVPFADLC STLERIQKSK GRAEKIRHFR EFLDSWRKFH DALHKNHKDV
 60 TDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP RDGKDALKLL NYRTPTGTHG
120 DAGDFAMIAY FVLKPRCLQK GSLTIQQVND LLDSIASNNS AKRKDLIKKS LLQLITQSSA
180 LEQKWLIRMI IKDLKLGVSQ QTIFSVFHND AAELHNVTTD LEKVCRQLHD PSVGLSDISI
240 TLFSAFKPML AAIADIEHIE KDMKHQSFYI ETKLDGERMQ MHKDGDVYKY FSRNGYNYTD
300 QFGASPTEGS LTPFIHNAFK ADIQICILDG EMMAYNPNTQ TFMQKGTKFD IKRMVEDSDL
360 QTCYCVFDVL MVNNKKLGHE TLRKRYEILS SIFTPIPGRI EIVQKTQAHT KNEVIDALNE
420 AIDKREEGIM VKQPLSIYKP DKRGEGWLKI KPEYVSGLMD ELDILIVGGY WGKGSRGGMM
480 SHFLCAVAEK PPPGEKPSVF HTLSRVGSGC TMKELYDLGL KLAKYWKPFH RKAPPSSILC
540 GTEKPEVYIE PCNSVIVQIK AAEIVPSDMY KTGCTLRFPR IEKIRDDKEW HECMTLDDLE
600 QLRGKASGKL ASKHLYIGGD DEPQEKKRKA APKMKKVIGI IEHLKAPNLT NVNKISNIFE
660 DVEFCVMSGT DSQPKPDLEN RIAEFGGYIV QNPGPDTYCV IAGSENIRVK NIILSNKHDV
720 VKPAWLLECF KTKSFVPWQP RFMIHMCPST KEHFAREYDC YGDSYFIDTD LNQLKEVFSG
780 IKNSNEQTPE EMASLIADLE YRYSWDCSPL SMFRRHTVYL DSYAVINDLS TKNEGTRLAI
840 KALELRFHGA KVVSCLAEGV SHVIIGEDHS RVADFKAFRR TFKRKFKILK ESWVTDSIDK
900 CELQEENQYL I
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
26424
Wei Y.-F.,Robins P.,Carter K.,Caldecott K.,Pappin D.J.C.,Yu G.-L.,Wang R.-P.,Shell B.K.,Nash R.A.,Schar P.,Barnes D.E.,Haseltine W.A.,Lindahl T.
Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination.
Mol. Cell. Biol.
15
3206-3216
1995
26426
Dunham A.,Matthews L.H.,Burton J.,Ashurst J.L.,Howe K.L.,Ashcroft K.J.,Beare D.M.,Burford D.C.,Hunt S.E.,Griffiths-Jones S.,Jones M.C.,Keenan S.J.,Oliver K.,Scott C.E.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Andrews D.T.,Ashwell R.I.S.,Babbage A.K.,Bagguley C.L.,Bailey J.,Bannerjee R.,Barlow K.F.,Bates K.,Beasley H.,Bird C.P.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burrill W.,Carder C.,Carter N.P.,Chapman J.C.,Clamp M.E.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.C.,Cobley V.,Collins J.E.,Corby N.,Coville G.J.,Deloukas P.,Dhami P.,Dunham I.,Dunn M.,Earthrowl M.E.,Ellington A.G.,Faulkner L.,Frankish A.G.,Frankland J.,French L.,Garner P.,Garnett J.,Gilbert J.G.R.,Gilson C.J.,Ghori J.,Grafham D.V.,Gribble S.M.,Griffiths C.,Hall R.E.,Hammond S.,Harley J.L.,Hart E.A.,Heath P.D.,Howden P.J.,Huckle E.J.,Hunt P.J.,Hunt A.R.,Johnson C.,Johnson D.,Kay M.,Kimberley A.M.,King A.,Laird G.K.,Langford C.J.,Lawlor S.,Leongamornlert D.A.,Lloyd D.M.,Lloyd C.,Loveland J.E.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,McLaren S.J.,McMurray A.,Milne S.,Moore M.J.F.,Nickerson T.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.M.,Rice C.M.,Searle S.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Steward C.A.,Sycamore N.,Tester J.,Thomas D.W.,Tracey A.,Tromans A.,Tubby B.,Wall M.,Wallis J.M.,West A.P.,Whitehead S.L.,Willey D.L.,Wilming L.,Wray P.W.,Wright M.W.,Young L.,Coulson A.,Durbin R.M.,Hubbard T.,Sulston J.E.,Beck S.,Bentley D.R.,Rogers J.,Ross M.T.
The DNA sequence and analysis of human chromosome 13.
Nature
428
522-528
2004
26427
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
26428
Robins P.,Lindahl T.
DNA ligase IV from HeLa cell nuclei.
J. Biol. Chem.
271
24257-24261
1996
26429
Grawunder U.,Wilm M.,Wu X.,Kulesza P.,Wilson T.E.,Mann M.,Lieber M.R.
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells.
Nature
388
492-495
1997
26430
Grawunder U.,Zimmer D.,Fugmann S.,Schwarz K.,Lieber M.R.
DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes.
Mol. Cell
2
477-484
1998
26431
Critchlow S.E.,Bowater R.P.,Jackson S.P.
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV.
Curr. Biol.
7
588-598
1997
26432
Chen L.,Trujillo K.,Sung P.,Tomkinson A.E.
Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase.
J. Biol. Chem.
275
26196-26205
2000
26433
Lee J.W.,Yannone S.M.,Chen D.J.,Povirk L.F.
Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro.
Cancer Res.
63
22-24
2003
26434
Calsou P.,Delteil C.,Frit P.,Drouet J.,Salles B.
Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.
J. Mol. Biol.
326
93-103
2003
26435
Gu J.,Lu H.,Tippin B.,Shimazaki N.,Goodman M.F.,Lieber M.R.
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps.
EMBO J.
26
1010-1023
2007
26436
Kanno S.,Kuzuoka H.,Sasao S.,Hong Z.,Lan L.,Nakajima S.,Yasui A.
A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.
EMBO J.
26
2094-2103
2007
26437
Recuero-Checa M.A.,Dore A.S.,Arias-Palomo E.,Rivera-Calzada A.,Scheres S.H.,Maman J.D.,Pearl L.H.,Llorca O.
Electron microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex.
DNA Repair
8
1380-1389
2009
26438
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
26439
Berg E.,Christensen M.O.,Dalla Rosa I.,Wannagat E.,Jaenicke R.U.,Roesner L.M.,Dirks W.G.,Boege F.,Mielke C.
XRCC4 controls nuclear import and distribution of Ligase IV and exchanges faster at damaged DNA in complex with Ligase IV.
DNA Repair
10
1232-1242
2011
26440
Francis D.B.,Kozlov M.,Chavez J.,Chu J.,Malu S.,Hanna M.,Cortes P.
DNA Ligase IV regulates XRCC4 nuclear localization.
DNA Repair
21
36-42
2014
26441
Fukuchi M.,Wanotayan R.,Liu S.,Imamichi S.,Sharma M.K.,Matsumoto Y.
Lysine 271 but not lysine 210 of XRCC4 is required for the nuclear localization of XRCC4 and DNA ligase IV.
Biochem. Biophys. Res. Commun.
461
687-694
2015
26442
Craxton A.,Somers J.,Munnur D.,Jukes-Jones R.,Cain K.,Malewicz M.
XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.
Cell Death Differ.
22
890-897
2015
26443
Xing M.,Yang M.,Huo W.,Feng F.,Wei L.,Jiang W.,Ning S.,Yan Z.,Li W.,Wang Q.,Hou M.,Dong C.,Guo R.,Gao G.,Ji J.,Zha S.,Lan L.,Liang H.,Xu D.
Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.
Nat. Commun.
6
6233-6233
2015
26444
Ochi T.,Blackford A.N.,Coates J.,Jhujh S.,Mehmood S.,Tamura N.,Travers J.,Wu Q.,Draviam V.M.,Robinson C.V.,Blundell T.L.,Jackson S.P.
DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.
Science
347
185-188
2015
26445
Sibanda B.L.,Critchlow S.E.,Begun J.,Pei X.Y.,Jackson S.P.,Blundell T.L.,Pellegrini L.
Crystal structure of an Xrcc4-DNA ligase IV complex.
Nat. Struct. Biol.
8
1015-1019
2001
26446
Wu P.Y.,Frit P.,Meesala S.,Dauvillier S.,Modesti M.,Andres S.N.,Huang Y.,Sekiguchi J.,Calsou P.,Salles B.,Junop M.S.
Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4.
Mol. Cell. Biol.
29
3163-3172
2009
26448
Chen S.,Lee L.,Naila T.,Fishbain S.,Wang A.,Tomkinson A.E.,Lees-Miller S.P.,He Y.
Structural basis of long-range to short-range synaptic transition in NHEJ.
Nature
593
294-298
2021
26449
Riballo E.,Critchlow S.E.,Teo S.-H.,Doherty A.J.,Priestley A.,Broughton B.C.,Kysela B.,Beamish H.,Plowman N.,Arlett C.F.,Lehmann A.R.,Jackson S.P.,Jeggo P.A.
Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient.
Curr. Biol.
9
699-702
1999
26450
Riballo E.,Doherty A.J.,Dai Y.,Stiff T.,Oettinger M.A.,Jeggo P.A.,Kysela B.
Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity.
J. Biol. Chem.
276
31124-31132
2001
26451
O'Driscoll M.,Cerosaletti K.M.,Girard P.-M.,Dai Y.,Stumm M.,Kysela B.,Hirsch B.,Gennery A.,Palmer S.E.,Seidel J.,Gatti R.A.,Varon R.,Oettinger M.A.,Neitzel H.,Jeggo P.A.,Concannon P.
DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency.
Mol. Cell
8
1175-1185
2001
26452
Roddam P.L.,Rollinson S.,O'Driscoll M.,Jeggo P.A.,Jack A.,Morgan G.J.
Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination.
J. Med. Genet.
39
900-905
2002
26453
van der Burg M.,van Veelen L.R.,Verkaik N.S.,Wiegant W.W.,Hartwig N.G.,Barendregt B.H.,Brugmans L.,Raams A.,Jaspers N.G.J.,Zdzienicka M.Z.,van Dongen J.J.M.,van Gent D.C.
A new type of radiosensitive T-B-NK(+) severe combined immunodeficiency caused by a LIG4 mutation.
J. Clin. Invest.
116
137-145
2006
26454
Murray J.E.,van der Burg M.,Ijspeert H.,Carroll P.,Wu Q.,Ochi T.,Leitch A.,Miller E.S.,Kysela B.,Jawad A.,Bottani A.,Brancati F.,Cappa M.,Cormier-Daire V.,Deshpande C.,Faqeih E.A.,Graham G.E.,Ranza E.,Blundell T.L.,Jackson A.P.,Stewart G.S.,Bicknell L.S.
Mutations in the NHEJ component XRCC4 cause primordial dwarfism.
Am. J. Hum. Genet.
96
412-424
2015