Sequence of AKT1_MOUSE
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MNDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQRES PLNNFSVAQC
60 QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWA TAIQTVADGL KRQEEETMDF
120 RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI
180 LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS
240 RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI
300 KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL
360 ILMEEIRFPR TLGPEAKSLL SGLLKKDPTQ RLGGGSEDAK EIMQHRFFAN IVWQDVYEKK
420 LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA
Download this sequence
in fasta formatDownload all sequences for 2.7.11.1
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
262950
Bellacosa A.,Franke T.F.,Gonzalez-Portal M.E.,Datta K.,Taguchi T.,Gardner J.,Cheng J.Q.,Testa J.R.,Tsichlis P.N.
Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications.
Oncogene
8
745-754
1993
262951
Yang Z.Z.,Tschopp O.,Hemmings-Mieszczak M.,Feng J.,Brodbeck D.,Perentes E.,Hemmings B.A.
Protein kinase B alpha/Akt1 regulates placental development and fetal growth.
J. Biol. Chem.
278
32124-32131
2003
262953
Carninci P.,Kasukawa T.,Katayama S.,Gough J.,Frith M.C.,Maeda N.,Oyama R.,Ravasi T.,Lenhard B.,Wells C.,Kodzius R.,Shimokawa K.,Bajic V.B.,Brenner S.E.,Batalov S.,Forrest A.R.,Zavolan M.,Davis M.J.,Wilming L.G.,Aidinis V.,Allen J.E.,Ambesi-Impiombato A.,Apweiler R.,Aturaliya R.N.,Bailey T.L.,Bansal M.,Baxter L.,Beisel K.W.,Bersano T.,Bono H.,Chalk A.M.,Chiu K.P.,Choudhary V.,Christoffels A.,Clutterbuck D.R.,Crowe M.L.,Dalla E.,Dalrymple B.P.,de Bono B.,Della Gatta G.,di Bernardo D.,Down T.,Engstrom P.,Fagiolini M.,Faulkner G.,Fletcher C.F.,Fukushima T.,Furuno M.,Futaki S.,Gariboldi M.,Georgii-Hemming P.,Gingeras T.R.,Gojobori T.,Green R.E.,Gustincich S.,Harbers M.,Hayashi Y.,Hensch T.K.,Hirokawa N.,Hill D.,Huminiecki L.,Iacono M.,Ikeo K.,Iwama A.,Ishikawa T.,Jakt M.,Kanapin A.,Katoh M.,Kawasawa Y.,Kelso J.,Kitamura H.,Kitano H.,Kollias G.,Krishnan S.P.,Kruger A.,Kummerfeld S.K.,Kurochkin I.V.,Lareau L.F.,Lazarevic D.,Lipovich L.,Liu J.,Liuni S.,McWilliam S.,Madan Babu M.,Madera M.,Marchionni L.,Matsuda H.,Matsuzawa S.,Miki H.,Mignone F.,Miyake S.,Morris K.,Mottagui-Tabar S.,Mulder N.,Nakano N.,Nakauchi H.,Ng P.,Nilsson R.,Nishiguchi S.,Nishikawa S.,Nori F.,Ohara O.,Okazaki Y.,Orlando V.,Pang K.C.,Pavan W.J.,Pavesi G.,Pesole G.,Petrovsky N.,Piazza S.,Reed J.,Reid J.F.,Ring B.Z.,Ringwald M.,Rost B.,Ruan Y.,Salzberg S.L.,Sandelin A.,Schneider C.,Schoenbach C.,Sekiguchi K.,Semple C.A.,Seno S.,Sessa L.,Sheng Y.,Shibata Y.,Shimada H.,Shimada K.,Silva D.,Sinclair B.,Sperling S.,Stupka E.,Sugiura K.,Sultana R.,Takenaka Y.,Taki K.,Tammoja K.,Tan S.L.,Tang S.,Taylor M.S.,Tegner J.,Teichmann S.A.,Ueda H.R.,van Nimwegen E.,Verardo R.,Wei C.L.,Yagi K.,Yamanishi H.,Zabarovsky E.,Zhu S.,Zimmer A.,Hide W.,Bult C.,Grimmond S.M.,Teasdale R.D.,Liu E.T.,Brusic V.,Quackenbush J.,Wahlestedt C.,Mattick J.S.,Hume D.A.,Kai C.,Sasaki D.,Tomaru Y.,Fukuda S.,Kanamori-Katayama M.,Suzuki M.,Aoki J.,Arakawa T.,Iida J.,Imamura K.,Itoh M.,Kato T.,Kawaji H.,Kawagashira N.,Kawashima T.,Kojima M.,Kondo S.,Konno H.,Nakano K.,Ninomiya N.,Nishio T.,Okada M.,Plessy C.,Shibata K.,Shiraki T.,Suzuki S.,Tagami M.,Waki K.,Watahiki A.,Okamura-Oho Y.,Suzuki H.,Kawai J.,Hayashizaki Y.
The transcriptional landscape of the mammalian genome.
Science
309
1559-1563
2005
262954
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
0-0
2009
262956
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
262957
Cong L.N.,Chen H.,Li Y.,Zhou L.,McGibbon M.A.,Taylor S.I.,Quon M.J.
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells.
Mol. Endocrinol.
11
1881-1890
1997
262958
Kitamura T.,Kitamura Y.,Kuroda S.,Hino Y.,Ando M.,Kotani K.,Konishi H.,Matsuzaki H.,Kikkawa U.,Ogawa W.,Kasuga M.
Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt.
Mol. Cell. Biol.
19
6286-6296
1999
262959
Mizuki M.,Fenski R.,Halfter H.,Matsumura I.,Schmidt R.,Muller C.,Gruning W.,Kratz-Albers K.,Serve S.,Steur C.,Buchner T.,Kienast J.,Kanakura Y.,Berdel W.E.,Serve H.
Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.
Blood
96
3907-3914
2000
262960
Pekarsky Y.,Koval A.,Hallas C.,Bichi R.,Tresini M.,Malstrom S.,Russo G.,Tsichlis P.,Croce C.M.
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation.
Proc. Natl. Acad. Sci. U.S.A.
97
3028-3033
2000
262961
Yamashita K.,Kajstura J.,Discher D.J.,Wasserlauf B.J.,Bishopric N.H.,Anversa P.,Webster K.A.
Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1.
Circ. Res.
88
609-614
2001
262962
Ravichandran L.V.,Chen H.,Li Y.,Quon M.J.
Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor.
Mol. Endocrinol.
15
1768-1780
2001
262963
Maira S.-M.,Galetic I.,Brazil D.P.,Kaech S.,Ingley E.,Thelen M.,Hemmings B.A.
Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane.
Science
294
374-380
2001
262964
Kane S.,Sano H.,Liu S.C.H.,Asara J.M.,Lane W.S.,Garner C.C.,Lienhard G.E.
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain.
J. Biol. Chem.
277
22115-22118
2002
262965
Xu J.,Liu D.,Songyang Z.
The role of Asp-462 in regulating Akt activity.
J. Biol. Chem.
277
35561-35566
2002
262966
Anai M.,Shojima N.,Katagiri H.,Ogihara T.,Sakoda H.,Onishi Y.,Ono H.,Fujishiro M.,Fukushima Y.,Horike N.,Viana A.,Kikuchi M.,Noguchi N.,Takahashi S.,Takata K.,Oka Y.,Uchijima Y.,Kurihara H.,Asano T.
A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.
J. Biol. Chem.
280
18525-18535
2005
262967
Urschel S.,Bassermann F.,Bai R.Y.,Munch S.,Peschel C.,Duyster J.
Phosphorylation of grb10 regulates its interaction with 14-3-3.
J. Biol. Chem.
280
16987-16993
2005
262968
Fritzius T.,Burkard G.,Haas E.,Heinrich J.,Schweneker M.,Bosse M.,Zimmermann S.,Frey A.D.,Caelers A.,Bachmann A.S.,Moelling K.
A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.
Biochem. J.
399
9-20
2006
262969
Villen J.,Beausoleil S.A.,Gerber S.A.,Gygi S.P.
Large-scale phosphorylation analysis of mouse liver.
Proc. Natl. Acad. Sci. U.S.A.
104
1488-1493
2007
262970
Nawa M.,Kanekura K.,Hashimoto Y.,Aiso S.,Matsuoka M.
A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB.
Cell. Signal.
20
493-505
2008
262971
Fritzius T.,Moelling K.
Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis.
EMBO J.
27
1399-1410
2008
262972
Kang E.S.,Han D.,Park J.,Kwak T.K.,Oh M.A.,Lee S.A.,Choi S.,Park Z.Y.,Kim Y.,Lee J.W.
O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells.
Exp. Cell Res.
314
2238-2248
2008
262973
Yang X.,Ongusaha P.P.,Miles P.D.,Havstad J.C.,Zhang F.,So W.V.,Kudlow J.E.,Michell R.H.,Olefsky J.M.,Field S.J.,Evans R.M.
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.
Nature
451
964-969
2008
262974
Virtanen C.,Paris J.,Takahashi M.
Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling.
J. Biol. Chem.
284
1636-1643
2009
262975
Kim J.Y.,Duan X.,Liu C.Y.,Jang M.H.,Guo J.U.,Pow-anpongkul N.,Kang E.,Song H.,Ming G.L.
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.
Neuron
63
761-773
2009
262976
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
262977
Rodgers J.T.,Haas W.,Gygi S.P.,Puigserver P.
Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis.
Cell Metab.
11
23-34
2010
262978
Oh W.J.,Wu C.C.,Kim S.J.,Facchinetti V.,Julien L.A.,Finlan M.,Roux P.P.,Su B.,Jacinto E.
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.
EMBO J.
29
3939-3951
2010
262979
Walz H.A.,Shi X.,Chouinard M.,Bue C.A.,Navaroli D.M.,Hayakawa A.,Zhou Q.L.,Nadler J.,Leonard D.M.,Corvera S.
Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2.
J. Biol. Chem.
285
14101-14108
2010
262980
Mahajan K.,Coppola D.,Challa S.,Fang B.,Chen Y.A.,Zhu W.,Lopez A.S.,Koomen J.,Engelman R.W.,Rivera C.,Muraoka-Cook R.S.,Cheng J.Q.,Schoenbrunn E.,Sebti S.M.,Earp H.S.,Mahajan N.P.
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
PLoS ONE
5
0-0
2010
262981
Arora D.,Stopp S.,Bohmer S.A.,Schons J.,Godfrey R.,Masson K.,Razumovskaya E.,Ronnstrand L.,Tanzer S.,Bauer R.,Bohmer F.D.,Muller J.P.
Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
J. Biol. Chem.
286
10918-10929
2011
262982
Wakatsuki S.,Saitoh F.,Araki T.
ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation.
Nat. Cell Biol.
13
1415-1423
2011
262983
Nicholson K.M.,Anderson N.G.
The protein kinase B/Akt signalling pathway in human malignancy.
Cell. Signal.
14
381-395
2002
262984
Hers I.,Vincent E.E.,Tavare J.M.
Akt signalling in health and disease.
Cell. Signal.
23
1515-1527
2011
262985
Heron-Milhavet L.,Khouya N.,Fernandez A.,Lamb N.J.
Akt1 and Akt2: differentiating the aktion.
Histol. Histopathol.
26
651-662
2011
262986
Nawa M.,Matsuoka M.
KCTD20, a relative of BTBD10, is a positive regulator of Akt.
BMC Biochem.
14
27-27
2013
262987
Yao Y.,Suraokar M.,Darnay B.G.,Hollier B.G.,Shaiken T.E.,Asano T.,Chen C.H.,Chang B.H.,Lu Y.,Mills G.B.,Sarbassov D.,Mani S.A.,Abbruzzese J.L.,Reddy S.A.
BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.
Sci. Signal.
6
0-0
2013
262988
Seo G.J.,Yang A.,Tan B.,Kim S.,Liang Q.,Choi Y.,Yuan W.,Feng P.,Park H.S.,Jung J.U.
Akt kinase-mediated checkpoint of cGAS DNA sensing pathway.
Cell Rep.
13
440-449
2015
262989
Cattin M.E.,Wang J.,Weldrick J.J.,Roeske C.L.,Mak E.,Thorn S.L.,DaSilva J.N.,Wang Y.,Lusis A.J.,Burgon P.G.
Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation.
J. Biol. Chem.
290
26699-26714
2015
262990
Oh S.,Paknejad N.,Hite R.K.
Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175.
Elife
9
0-0
2020
