Sequence of UHRF1_HUMAN
EC Number:2.3.2.27
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine
Other sequences found for EC No. 2.3.2.27
General information:
Sequence
0 MWIQVRTMDG RQTHTVDSLS RLTKVEELRR KIQELFHVEP GLQRLFYRGK QMEDGHTLFD
60 YEVRLNDTIQ LLVRQSLVLP HSTKERDSEL SDTDSGCCLG QSESDKSSTH GEAAAETDSR
120 PADEDMWDET ELGLYKVNEY VDARDTNMGA WFEAQVVRVT RKAPSRDEPC SSTSRPALEE
180 DVIYHVKYDD YPENGVVQMN SRDVRARART IIKWQDLEVG QVVMLNYNPD NPKERGFWYD
240 AEISRKRETR TARELYANVV LGDDSLNDCR IIFVDEVFKI ERPGEGSPMV DNPMRRKSGP
300 SCKHCKDDVN RLCRVCACHL CGGRQDPDKQ LMCDECDMAF HIYCLDPPLS SVPSEDEWYC
360 PECRNDASEV VLAGERLRES KKKAKMASAT SSSQRDWGKG MACVGRTKEC TIVPSNHYGP
420 IPGIPVGTMW RFRVQVSESG VHRPHVAGIH GRSNDGAYSL VLAGGYEDDV DHGNFFTYTG
480 SGGRDLSGNK RTAEQSCDQK LTNTNRALAL NCFAPINDQE GAEAKDWRSG KPVRVVRNVK
540 GGKNSKYAPA EGNRYDGIYK VVKYWPEKGK SGFLVWRYLL RRDDDEPGPW TKEGKDRIKK
600 LGLTMQYPEG YLEALANRER EKENSKREEE EQQEGGFASP RTGKGKWKRK SAGGGPSRAG
660 SPRRTSKKTK VEPYSLTAQQ SSLIREDKSN AKLWNEVLAS LKDRPASGSP FQLFLSKVEE
720 TFQCICCQEL VFRPITTVCQ HNVCKDCLDR SFRAQVFSCP ACRYDLGRSY AMQVNQPLQT
780 VLNQLFPGYG NGR
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
247166
Hopfner R.,Mousli M.,Jeltsch J.-M.,Voulgaris A.,Lutz Y.,Marin C.,Bellocq J.-P.,Oudet P.,Bronner C.
ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIa expression.
Cancer Res.
60
121-128
2000
247167
Muto M.,Fujimori A.,Nenoi M.,Daino K.,Matsuda Y.,Kuroiwa A.,Kubo E.,Kanari Y.,Utsuno M.,Tsuji H.,Ukai H.,Mita K.,Takahagi M.,Tatsumi K.
Isolation and characterization of a novel human radiosusceptibility gene, NP95.
Radiat. Res.
166
723-733
2006
247169
Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.
The full-ORF clone resource of the German cDNA consortium.
BMC Genomics
8
399-399
2007
247170
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
247172
Grimwood J.,Gordon L.A.,Olsen A.S.,Terry A.,Schmutz J.,Lamerdin J.E.,Hellsten U.,Goodstein D.,Couronne O.,Tran-Gyamfi M.,Aerts A.,Altherr M.,Ashworth L.,Bajorek E.,Black S.,Branscomb E.,Caenepeel S.,Carrano A.V.,Caoile C.,Chan Y.M.,Christensen M.,Cleland C.A.,Copeland A.,Dalin E.,Dehal P.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Garcia C.,Georgescu A.M.,Glavina T.,Gomez M.,Gonzales E.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Ho I.,Huang W.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Larionov V.,Leem S.-H.,Lopez F.,Lou Y.,Lowry S.,Malfatti S.,Martinez D.,McCready P.M.,Medina C.,Morgan J.,Nelson K.,Nolan M.,Ovcharenko I.,Pitluck S.,Pollard M.,Popkie A.P.,Predki P.,Quan G.,Ramirez L.,Rash S.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,She X.,Smith D.,Slezak T.,Solovyev V.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wagner M.,Wheeler J.,Wu K.,Xie G.,Yang J.,Dubchak I.,Furey T.S.,DeJong P.,Dickson M.,Gordon D.,Eichler E.E.,Pennacchio L.A.,Richardson P.,Stubbs L.,Rokhsar D.S.,Myers R.M.,Rubin E.M.,Lucas S.M.
The DNA sequence and biology of human chromosome 19.
Nature
428
529-535
2004
247174
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
247175
Mousli M.,Hopfner R.,Abbady A.-Q.,Monte D.,Jeanblanc M.,Oudet P.,Louis B.,Bronner C.
ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells.
Br. J. Cancer
89
120-127
2003
247176
Trotzier M.-A.,Bronner C.,Bathami K.,Mathieu E.,Abbady A.-Q.,Jeanblanc M.,Muller C.D.,Rochette-Egly C.,Mousli M.
Phosphorylation of ICBP90 by protein kinase A enhances topoisomerase IIalpha expression.
Biochem. Biophys. Res. Commun.
319
590-595
2004
247177
Arima Y.,Hirota T.,Bronner C.,Mousli M.,Fujiwara T.,Niwa S.,Ishikawa H.,Saya H.
Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition.
Genes Cells
9
131-142
2004
247178
Unoki M.,Nishidate T.,Nakamura Y.
ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain.
Oncogene
23
7601-7610
2004
247179
Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Cell
127
635-648
2006
247180
Beausoleil S.A.,Villen J.,Gerber S.A.,Rush J.,Gygi S.P.
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Nat. Biotechnol.
24
1285-1292
2006
247181
Bostick M.,Kim J.K.,Esteve P.O.,Clark A.,Pradhan S.,Jacobsen S.E.
UHRF1 plays a role in maintaining DNA methylation in mammalian cells.
Science
317
1760-1764
2007
247182
Cantin G.T.,Yi W.,Lu B.,Park S.K.,Xu T.,Lee J.-D.,Yates J.R. III
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
J. Proteome Res.
7
1346-1351
2008
247183
Karagianni P.,Amazit L.,Qin J.,Wong J.
ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation.
Mol. Cell. Biol.
28
705-717
2008
247184
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
247185
Unoki M.,Kelly J.D.,Neal D.E.,Ponder B.A.,Nakamura Y.,Hamamoto R.
UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer.
Br. J. Cancer
101
98-105
2009
247186
Kim J.K.,Esteve P.O.,Jacobsen S.E.,Pradhan S.
UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells.
Nucleic Acids Res.
37
493-505
2009
247187
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
247188
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
247189
Rottach A.,Frauer C.,Pichler G.,Bonapace I.M.,Spada F.,Leonhardt H.
The multi-domain protein Np95 connects DNA methylation and histone modification.
Nucleic Acids Res.
38
1796-1804
2010
247190
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
247191
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
247192
Felle M.,Joppien S.,Nemeth A.,Diermeier S.,Thalhammer V.,Dobner T.,Kremmer E.,Kappler R.,Langst G.
The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.
Nucleic Acids Res.
39
8355-8365
2011
247193
Frauer C.,Hoffmann T.,Bultmann S.,Casa V.,Cardoso M.C.,Antes I.,Leonhardt H.
Recognition of 5-hydroxymethylcytosine by the Uhrf1 SRA domain.
PLoS ONE
6
0-0
2011
247194
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
0-0
2011
247195
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
247196
Guan D.,Factor D.,Liu Y.,Wang Z.,Kao H.Y.
The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein.
Oncogene
32
3819-3828
2013
247197
Sabatino L.,Fucci A.,Pancione M.,Carafa V.,Nebbioso A.,Pistore C.,Babbio F.,Votino C.,Laudanna C.,Ceccarelli M.,Altucci L.,Bonapace I.M.,Colantuoni V.
UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression.
Oncogene
31
5061-5072
2012
247198
Babbio F.,Pistore C.,Curti L.,Castiglioni I.,Kunderfranco P.,Brino L.,Oudet P.,Seiler R.,Thalman G.N.,Roggero E.,Sarti M.,Pinton S.,Mello-Grand M.,Chiorino G.,Catapano C.V.,Carbone G.M.,Bonapace I.M.
The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression.
Oncogene
31
4878-4887
2012
247199
Ma H.,Chen H.,Guo X.,Wang Z.,Sowa M.E.,Zheng L.,Hu S.,Zeng P.,Guo R.,Diao J.,Lan F.,Harper J.W.,Shi Y.G.,Xu Y.,Shi Y.
M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability.
Proc. Natl. Acad. Sci. U.S.A.
109
4828-4833
2012
247200
Hendriks I.A.,D'Souza R.C.,Yang B.,Verlaan-de Vries M.,Mann M.,Vertegaal A.C.
Uncovering global SUMOylation signaling networks in a site-specific manner.
Nat. Struct. Mol. Biol.
21
927-936
2014
247201
Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
Nat. Struct. Mol. Biol.
24
325-336
2017
247202
Motnenko A.,Liang C.C.,Yang D.,Lopez-Martinez D.,Yoshikawa Y.,Zhan B.,Ward K.E.,Tian J.,Haas W.,Spingardi P.,Kessler B.M.,Kriaucionis S.,Gygi S.P.,Cohn M.A.
Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein.
PLoS Genet.
14
0-0
2018
247203
Yu Z.,Feng J.,Wang W.,Deng Z.,Zhang Y.,Xiao L.,Wang Z.,Liu C.,Liu Q.,Chen S.,Wu M.
The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
Oncogene
39
3163-3178
2020
247205
Delagoutte B.,Lallous N.,Birck C.,Oudet P.,Samama J.P.
Expression, purification, crystallization and preliminary crystallographic study of the SRA domain of the human UHRF1 protein.
Acta Crystallogr. F
64
922-925
2008
247206
Qian C.,Li S.,Jakoncic J.,Zeng L.,Walsh M.J.,Zhou M.M.
Structure and hemimethylated CpG binding of the SRA domain from human UHRF1.
J. Biol. Chem.
283
34490-34494
2008
247207
Avvakumov G.V.,Walker J.R.,Xue S.,Li Y.,Duan S.,Bronner C.,Arrowsmith C.H.,Dhe-Paganon S.
Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1.
Nature
455
822-825
2008
247208
Hu L.,Li Z.,Wang P.,Lin Y.,Xu Y.
Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2.
Cell Res.
21
1374-1378
2011
247209
Wang C.,Shen J.,Yang Z.,Chen P.,Zhao B.,Hu W.,Lan W.,Tong X.,Wu H.,Li G.,Cao C.
Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger.
Cell Res.
21
1379-1382
2011
247210
Nady N.,Lemak A.,Walker J.R.,Avvakumov G.V.,Kareta M.S.,Achour M.,Xue S.,Duan S.,Allali-Hassani A.,Zuo X.,Wang Y.X.,Bronner C.,Chedin F.,Arrowsmith C.H.,Dhe-Paganon S.
Recognition of multivalent histone states associated with heterochromatin by UHRF1 protein.
J. Biol. Chem.
286
24300-24311
2011
247211
Rajakumara E.,Wang Z.,Ma H.,Hu L.,Chen H.,Lin Y.,Guo R.,Wu F.,Li H.,Lan F.,Shi Y.G.,Xu Y.,Patel D.J.,Shi Y.
PHD finger recognition of unmodified histone H3R2 links UHRF1 to regulation of euchromatic gene expression.
Mol. Cell
43
275-284
2011
247212
Lallous N.,Legrand P.,McEwen A.G.,Ramon-Maiques S.,Samama J.P.,Birck C.
The PHD finger of human UHRF1 reveals a new subgroup of unmethylated histone H3 tail readers.
PLoS ONE
6
0-0
2011
247213
Xie S.,Jakoncic J.,Qian C.
UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail.
J. Mol. Biol.
415
318-328
2012
247214
Arita K.,Isogai S.,Oda T.,Unoki M.,Sugita K.,Sekiyama N.,Kuwata K.,Hamamoto R.,Tochio H.,Sato M.,Ariyoshi M.,Shirakawa M.
Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1.
Proc. Natl. Acad. Sci. U.S.A.
109
12950-12955
2012