Sequence of TRXR1_RAT
EC Number:1.8.1.9
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+
Other sequences found for EC No. 1.8.1.9
General information:
Sequence
0 MNDSKDAPKS YDFDLIIIGG GSGGLAAAKE AAKFDKKVMV LDFVTPTPLG TRWGLGGTCV
60 NVGCIPKKLM HQAALLGQAL KDSRNYGWKL EDTVKHDWEK MTESVQNHIG SLNWGYRVAL
120 REKKVVYENA YGKFIGPHKI MATNNKGKEK VYSAERFLIA TGERPRYLGI PGDKEYCISS
180 DDLFSLPYCP GKTLVVGASY VALECAGFLA GIGLDVTVMV RSILLRGFDQ DMANKIGEHM
240 EEHGIKFIRQ FVPTKIEQIE AGTPGRLKVT AKSTNSEETI EDEFNTVLLA VGRDSCTRTI
300 GLETVGVKIN EKTGKIPVTD EEQTNVPYIY AIGDILEGKL ELTPVAIQAG RLLAQRLYGG
360 STVKCDYDNV PTTVFTPLEY GCCGLSEEKA VEKFGEENIE VYHSFFWPLE WTVPSRDNNK
420 CYAKVICNLK DNERVVGFHV LGPNAGEVTQ GFAAALKCGL TKQQLDSTIG IHPVCAEIFT
480 TLSVTKRSGG DILQSGCUG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
244826
Zhong L.,Arner E.S.J.,Ljung J.,Aaslund F.,Holmgren A.
Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue.
J. Biol. Chem.
273
8581-8591
1998
244827
Fujiwara N.,Fujii T.,Fujii J.,Taniguchi N.
Functional expression of rat thioredoxin reductase: selenocysteine insertion sequence element is essential for the active enzyme.
Biochem. J.
340
439-444
1999
244829
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
244830
Zhong L.,Holmgren A.
Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutations.
J. Biol. Chem.
275
18121-18128
2000
244831
Sandalova T.,Zhong L.,Lindqvist Y.,Holmgren A.,Schneider G.
Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme.
Proc. Natl. Acad. Sci. U.S.A.
98
9533-9538
2001
