Sequence of TOR1_YEAST
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
non-specific serine/threonine protein kinase
P35169
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
2470
281140
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MEPHEEQIWK SKLLKAANND MDMDRNVPLA PNLNVNMNMK MNASRNGDEF GLTSSRFDGV
60 VIGSNGDVNF KPILEKIFRE LTSDYKEERK LASISLFDLL VSLEHELSIE EFQAVSNDIN
120 NKILELVHTK KTSTRVGAVL SIDTLISFYA YTERLPNETS RLAGYLRGLI PSNDVEVMRL
180 AAKTLGKLAV PGGTYTSDFV EFEIKSCLEW LTASTEKNSF SSSKPDHAKH AALLIITALA
240 ENCPYLLYQY LNSILDNIWR ALRDPHLVIR IDASITLAKC LSTLRNRDPQ LTSQWVQRLA
300 TSCEYGFQVN TLECIHASLL VYKEILFLKD PFLNQVFDQM CLNCIAYENH KAKMIREKIY
360 QIVPLLASFN PQLFAGKYLH QIMDNYLEIL TNAPANKIPH LKDDKPQILI SIGDIAYEVG
420 PDIAPYVKQI LDYIEHDLQT KFKFRKKFEN EIFYCIGRLA VPLGPVLGKL LNRNILDLMF
480 KCPLSDYMQE TFQILTERIP SLGPKINDEL LNLVCSTLSG TPFIQPGSPM EIPSFSRERA
540 REWRNKNILQ KTGESNDDNN DIKIIIQAFR MLKNIKSRFS LVEFVRIVAL SYIEHTDPRV
600 RKLAALTSCE IYVKDNICKQ TSLHSLNTVS EVLSKLLAIT IADPLQDIRL EVLKNLNPCF
660 DPQLAQPDNL RLLFTALHDE SFNIQSVAME LVGRLSSVNP AYVIPSIRKI LLELLTKLKF
720 STSSREKEET ASLLCTLIRS SKDVAKPYIE PLLNVLLPKF QDTSSTVAST ALRTIGELSV
780 VGGEDMKIYL KDLFPLIIKT FQDQSNSFKR EAALKALGQL AASSGYVIDP LLDYPELLGI
840 LVNILKTENS QNIRRQTVTL IGILGAIDPY RQKEREVTST TDISTEQNAP PIDIALLMQG
900 MSPSNDEYYT TVVIHCLLKI LKDPSLSSYH TAVIQAIMHI FQTLGLKCVS FLDQIIPTIL
960 DVMRTCSQSL LEFYFQQLCS LIIIVRQHIR PHVDSIFQAI KDFSSVAKLQ ITLVSVIEAI
1020 SKALEGEFKR LVPLTLTLFL VILENDKSSD KVLSRRVLRL LESFGPNLEG YSHLITPKIV
1080 QMAEFTSGNL QRSAIITIGK LAKDVDLFEM SSRIVHSLLR VLSSTTSDEL SKVIMNTLSL
1140 LLIQMGTSFA IFIPVINEVL MKKHIQHTIY DDLTNRILNN DVLPTKILEA NTTDYKPAEQ
1200 MEAADAGVAK LPINQSVLKS AWNSSQQRTK EDWQEWSKRL SIQLLKESPS HALRACSNLA
1260 SMYYPLAKEL FNTAFACVWT ELYSQYQEDL IGSLCIALSS PLNPPEIHQT LLNLVEFMEH
1320 DDKALPIPTQ SLGEYAERCH AYAKALHYKE IKFIKEPENS TIESLISINN QLNQTDAAIG
1380 ILKHAQQHHS LQLKETWFEK LERWEDALHA YNEREKAGDT SVSVTLGKMR SLHALGEWEQ
1440 LSQLAARKWK VSKLQTKKLI APLAAGAAWG LGEWDMLEQY ISVMKPKSPD KEFFDAILYL
1500 HKNDYDNASK HILNARDLLV TEISALINES YNRAYSVIVR TQIITEFEEI IKYKQLPPNS
1560 EKKLHYQNLW TKRLLGCQKN VDLWQRVLRV RSLVIKPKQD LQIWIKFANL CRKSGRMRLA
1620 NKALNMLLEG GNDPSLPNTF KAPPPVVYAQ LKYIWATGAY KEALNHLIGF TSRLAHDLGL
1680 DPNNMIAQSV KLSSASTAPY VEEYTKLLAR CFLKQGEWRI ATQPNWRNTN PDAILGSYLL
1740 ATHFDKNWYK AWHNWALANF EVISMVQEET KLNGGKNDDD DDTAVNNDNV RIDGSILGSG
1800 SLTINGNRYP LELIQRHVVP AIKGFFHSIS LLETSCLQDT LRLLTLLFNF GGIKEVSQAM
1860 YEGFNLMKIE NWLEVLPQLI SRIHQPDPTV SNSLLSLLSD LGKAHPQALV YPLTVAIKSE
1920 SVSRQKAALS IIEKIRIHSP VLVNQAELVS HELIRVAVLW HELWYEGLED ASRQFFVEHN
1980 IEKMFSTLEP LHKHLGNEPQ TLSEVSFQKS FGRDLNDAYE WLNNYKKSKD INNLNQAWDI
2040 YYNVFRKITR QIPQLQTLDL QHVSPQLLAT HDLELAVPGT YFPGKPTIRI AKFEPLFSVI
2100 SSKQRPRKFS IKGSDGKDYK YVLKGHEDIR QDSLVMQLFG LVNTLLKNDS ECFKRHLDIQ
2160 QYPAIPLSPK SGLLGWVPNS DTFHVLIREH RDAKKIPLNI EHWVMLQMAP DYENLTLLQK
2220 IEVFTYALDN TKGQDLYKIL WLKSRSSETW LERRTTYTRS LAVMSMTGYI LGLGDRHPSN
2280 LMLDRITGKV IHIDFGDCFE AAILREKYPE KVPFRLTRML TYAMEVSGIE GSFRITCENV
2340 MRVLRDNKES LMAILEAFAL DPLIHWGFDL PPQKLTEQTG IPLPLINPSE LLRKGAITVE
2400 EAANMEAEQQ NETKNARAML VLRRITDKLT GNDIKRFNEL DVPEQVDKLI QQATSIERLC
2460 QHYIGWCPFW
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
242857
Cafferkey R.,Young P.R.,McLaughlin M.M.,Bergsma D.J.,Koltin Y.,Sathe G.M.,Faucette L.,Eng W.-K.,Johnson R.K.,Livi G.P.
Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.
Mol. Cell. Biol.
13
6012-6023
1993
242858
Helliwell S.B.,Wagner P.,Kunz J.,Deuter-Reinhard M.,Henriquez R.,Hall M.N.
TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.
Mol. Biol. Cell
5
105-118
1994
242859
Huang M.-E.,Manus V.,Chuat J.-C.,Galibert F.
Analysis of a 62 kb DNA sequence of chromosome X reveals 36 open reading frames and a gene cluster with a counterpart on chromosome XI.
Yeast
12
869-875
1996
242860
Galibert F.,Alexandraki D.,Baur A.,Boles E.,Chalwatzis N.,Chuat J.-C.,Coster F.,Cziepluch C.,de Haan M.,Domdey H.,Durand P.,Entian K.-D.,Gatius M.,Goffeau A.,Grivell L.A.,Hennemann A.,Herbert C.J.,Heumann K.,Hilger F.,Hollenberg C.P.,Huang M.-E.,Jacq C.,Jauniaux J.-C.,Katsoulou C.,Kirchrath L.,Kleine K.,Kordes E.,Koetter P.,Liebl S.,Louis E.J.,Manus V.,Mewes H.-W.,Miosga T.,Obermaier B.,Perea J.,Pohl T.M.,Portetelle D.,Pujol A.,Purnelle B.,Ramezani Rad M.,Rasmussen S.W.,Rose M.,Rossau R.,Schaaff-Gerstenschlaeger I.,Smits P.H.M.,Scarcez T.,Soriano N.,To Van D.,Tzermia M.,Van Broekhoven A.,Vandenbol M.,Wedler H.,von Wettstein D.,Wambutt R.,Zagulski M.,Zollner A.,Karpfinger-Hartl L.
Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.
EMBO J.
15
2031-2049
1996
242861
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
242862
Zheng X.-F.,Florentino D.,Chen J.,Crabtree G.R.,Schreiber S.L.
TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin.
Cell
82
121-130
1995
242863
Barbet N.C.,Schneider U.,Helliwell S.B.,Stansfield I.,Tuite M.F.,Hall M.N.
TOR controls translation initiation and early G1 progression in yeast.
Mol. Biol. Cell
7
25-42
1996
242864
Schmidt A.,Beck T.,Koller A.,Kunz J.,Hall M.N.
The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease.
EMBO J.
17
6924-6931
1998
242865
Berset C.,Trachsel H.,Altmann M.
The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae.
Proc. Natl. Acad. Sci. U.S.A.
95
4264-4269
1998
242866
Jiang Y.,Broach J.R.
Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast.
EMBO J.
18
2782-2792
1999
242867
Powers T.,Walter P.
Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae.
Mol. Biol. Cell
10
987-1000
1999
242868
Alarcon C.M.,Heitman J.,Cardenas M.E.
Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.
Mol. Biol. Cell
10
2531-2546
1999
242869
Beck T.,Hall M.N.
The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors.
Nature
402
689-692
1999
242870
Kunz J.,Schneider U.,Howald I.,Schmidt A.,Hall M.N.
HEAT repeats mediate plasma membrane localization of Tor2p in yeast.
J. Biol. Chem.
275
37011-37020
2000
242871
Kamada Y.,Funakoshi T.,Shintani T.,Nagano K.,Ohsumi M.,Ohsumi Y.
Tor-mediated induction of autophagy via an Apg1 protein kinase complex.
J. Cell Biol.
150
1507-1513
2000
242872
Jacinto E.,Guo B.,Arndt K.T.,Schmelzle T.,Hall M.N.
TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.
Mol. Cell
8
1017-1026
2001
242873
Loewith R.,Jacinto E.,Wullschleger S.,Lorberg A.,Crespo J.L.,Bonenfant D.,Oppliger W.,Jenoe P.,Hall M.N.
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
Mol. Cell
10
457-468
2002
242874
Wedaman K.P.,Reinke A.,Anderson S.,Yates J.R. III,McCaffery J.M.,Powers T.
Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae.
Mol. Biol. Cell
14
1204-1220
2003
242875
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
242876
Martin D.E.,Soulard A.,Hall M.N.
TOR regulates ribosomal protein gene expression via PKA and the forkhead transcription factor FHL1.
Cell
119
969-979
2004
242877
Urban J.,Soulard A.,Huber A.,Lippman S.,Mukhopadhyay D.,Deloche O.,Wanke V.,Anrather D.,Ammerer G.,Riezman H.,Broach J.R.,De Virgilio C.,Hall M.N.,Loewith R.
Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.
Mol. Cell
26
663-674
2007
242878
Gonzalez A.,Shimobayashi M.,Eisenberg T.,Merle D.A.,Pendl T.,Hall M.N.,Moustafa T.
TORC1 promotes phosphorylation of ribosomal protein S6 via the AGC kinase Ypk3 in Saccharomyces cerevisiae.
PLoS ONE
10
0-0
2015
242879
Tanigawa M.,Maeda T.
An In Vitro TORC1 Kinase Assay That Recapitulates the Gtr-Independent Glutamine-Responsive TORC1 Activation Mechanism on Yeast Vacuoles.
Mol. Cell. Biol.
37
0-0
2017
242880
Ukai H.,Araki Y.,Kira S.,Oikawa Y.,May A.I.,Noda T.
Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membrane.
PLoS Genet.
14
0-0
2018
242881
Uemura S.,Mochizuki T.,Amemiya K.,Kurosaka G.,Yazawa M.,Nakamoto K.,Ishikawa Y.,Izawa S.,Abe F.
Amino acid homeostatic control by TORC1 in Saccharomyces cerevisiae under high hydrostatic pressure.
J. Cell Sci.
133
0-0
2020
242882
Tanigawa M.,Yamamoto K.,Nagatoishi S.,Nagata K.,Noshiro D.,Noda N.N.,Tsumoto K.,Maeda T.
A glutamine sensor that directly activates TORC1.
Commun. Biol.
4
1093-1093
2021
242883
Dames S.A.,Mulet J.M.,Rathgeb-Szabo K.,Hall M.N.,Grzesiek S.
The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability.
J. Biol. Chem.
280
20558-20564
2005
