Sequence of ACE_HUMAN

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
peptidyl-dipeptidase A
P12821
Homo sapiens
1306
149715
Reaction
release of a C-terminal dipeptide, oligopeptide-/-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II
Sequences with same EC No.
Sequence
show sequence in fasta format
   0 MGAASGRRGP GLLLPLPLLL LLPPQPALAL DPGLQPGNFS ADEAGAQLFA QSYNSSAEQV
  60 LFQSVAASWA HDTNITAENA RRQEEAALLS QEFAEAWGQK AKELYEPIWQ NFTDPQLRRI
 120 IGAVRTLGSA NLPLAKRQQY NALLSNMSRI YSTAKVCLPN KTATCWSLDP DLTNILASSR
 180 SYAMLLFAWE GWHNAAGIPL KPLYEDFTAL SNEAYKQDGF TDTGAYWRSW YNSPTFEDDL
 240 EHLYQQLEPL YLNLHAFVRR ALHRRYGDRY INLRGPIPAH LLGDMWAQSW ENIYDMVVPF
 300 PDKPNLDVTS TMLQQGWNAT HMFRVAEEFF TSLELSPMPP EFWEGSMLEK PADGREVVCH
 360 ASAWDFYNRK DFRIKQCTRV TMDQLSTVHH EMGHIQYYLQ YKDLPVSLRR GANPGFHEAI
 420 GDVLALSVST PEHLHKIGLL DRVTNDTESD INYLLKMALE KIAFLPFGYL VDQWRWGVFS
 480 GRTPPSRYNF DWWYLRTKYQ GICPPVTRNE THFDAGAKFH VPNVTPYIRY FVSFVLQFQF
 540 HEALCKEAGY EGPLHQCDIY RSTKAGAKLR KVLQAGSSRP WQEVLKDMVG LDALDAQPLL
 600 KYFQPVTQWL QEQNQQNGEV LGWPEYQWHP PLPDNYPEGI DLVTDEAEAS KFVEEYDRTS
 660 QVVWNEYAEA NWNYNTNITT ETSKILLQKN MQIANHTLKY GTQARKFDVN QLQNTTIKRI
 720 IKKVQDLERA ALPAQELEEY NKILLDMETT YSVATVCHPN GSCLQLEPDL TNVMATSRKY
 780 EDLLWAWEGW RDKAGRAILQ FYPKYVELIN QAARLNGYVD AGDSWRSMYE TPSLEQDLER
 840 LFQELQPLYL NLHAYVRRAL HRHYGAQHIN LEGPIPAHLL GNMWAQTWSN IYDLVVPFPS
 900 APSMDTTEAM LKQGWTPRRM FKEADDFFTS LGLLPVPPEF WNKSMLEKPT DGREVVCHAS
 960 AWDFYNGKDF RIKQCTTVNL EDLVVAHHEM GHIQYFMQYK DLPVALREGA NPGFHEAIGD
1020 VLALSVSTPK HLHSLNLLSS EGGSDEHDIN FLMKMALDKI AFIPFSYLVD QWRWRVFDGS
1080 ITKENYNQEW WSLRLKYQGL CPPVPRTQGD FDPGAKFHIP SSVPYIRYFV SFIIQFQFHE
1140 ALCQAAGHTG PLHKCDIYQS KEAGQRLATA MKLGFSRPWP EAMQLITGQP NMSASAMLSY
1200 FKPLLDWLRT ENELHGEKLG WPQYNWTPNS ARSEGPLPDS GRVSFLGLDL DAQQARVGQW
1260 LLLFLGIALL VATLGLSQRL FSIRHRSLHR HSHGPQFGSE VELRHS
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
249305
Soubrier F.,Alhenc-Gelas F.,Hubert C.,Allegrini J.,John M.,Tregear G.,Corbol P.
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.
Proc. Natl. Acad. Sci. U.S.A.
85
9386-9390
1988
249306
Lattion A.L.,Soubrier F.,Allegrini J.,Hubert C.,Corvol P.,Alhenc-Gelas F.
The testicular transcript of the angiotensin I-converting enzyme encodes for the ancestral, non-duplicated form of the enzyme.
FEBS Lett.
252
99-104
1989
249307
Ehlers M.R.W.,Fox E.A.,Strydom D.J.,Riordan J.F.
Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme.
Proc. Natl. Acad. Sci. U.S.A.
86
7741-7745
1989
249308
Rieder M.J.,Taylor S.L.,Clark A.G.,Nickerson D.A.
Sequence variation in the human angiotensin converting enzyme.
Nat. Genet.
22
59-62
1999
249309
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
249312
Zody M.C.,Garber M.,Adams D.J.,Sharpe T.,Harrow J.,Lupski J.R.,Nicholson C.,Searle S.M.,Wilming L.,Young S.K.,Abouelleil A.,Allen N.R.,Bi W.,Bloom T.,Borowsky M.L.,Bugalter B.E.,Butler J.,Chang J.L.,Chen C.-K.,Cook A.,Corum B.,Cuomo C.A.,de Jong P.J.,DeCaprio D.,Dewar K.,FitzGerald M.,Gilbert J.,Gibson R.,Gnerre S.,Goldstein S.,Grafham D.V.,Grocock R.,Hafez N.,Hagopian D.S.,Hart E.,Norman C.H.,Humphray S.,Jaffe D.B.,Jones M.,Kamal M.,Khodiyar V.K.,LaButti K.,Laird G.,Lehoczky J.,Liu X.,Lokyitsang T.,Loveland J.,Lui A.,Macdonald P.,Major J.E.,Matthews L.,Mauceli E.,McCarroll S.A.,Mihalev A.H.,Mudge J.,Nguyen C.,Nicol R.,O'Leary S.B.,Osoegawa K.,Schwartz D.C.,Shaw-Smith C.,Stankiewicz P.,Steward C.,Swarbreck D.,Venkataraman V.,Whittaker C.A.,Yang X.,Zimmer A.R.,Bradley A.,Hubbard T.,Birren B.W.,Rogers J.,Lander E.S.,Nusbaum C.
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Nature
440
1045-1049
2006
249313
Takeuchi K.,Shimizu T.,Ohishi N.,Seyama Y.,Takaku F.,Yotsumoto H.
Purification of human lung angiotensin-converting enzyme by high-performance liquid chromatography: properties and N-terminal amino acid sequence.
J. Biochem.
106
442-445
1989
249314
Sugimura K.,Tian X.-L.,Hoffmann S.,Ganten D.,Bader M.
Alternative splicing of the mRNA coding for the human endothelial angiotensin-converting enzyme: a new mechanism for solubilization.
Biochem. Biophys. Res. Commun.
247
466-472
1998
249315
Ehlers M.R.W.,Riordan J.F.
Angiotensin-converting enzyme: zinc- and inhibitor-binding stoichiometries of the somatic and testis isozymes.
Biochemistry
30
7118-7126
1991
249316
Sturrock E.D.,Yu X.C.,Wu Z.,Biemann K.,Riordan J.F.
Assignment of free and disulfide-bonded cysteine residues in testis angiotensin-converting enzyme: functional implications.
Biochemistry
35
9560-9566
1996
249317
Yu X.C.,Sturrock E.D.,Wu Z.,Biemann K.,Ehlers M.R.W.,Riordan J.F.
Identification of N-linked glycosylation sites in human testis angiotensin-converting enzyme and expression of an active deglycosylated form.
J. Biol. Chem.
272
3511-3519
1997
249318
Woodman Z.L.,Oppong S.Y.,Cook S.,Hooper N.M.,Schwager S.L.U.,Brandt W.F.,Ehlers M.R.W.,Sturrock E.D.
Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites.
Biochem. J.
347
711-718
2000
249319
Donoghue M.,Hsieh F.,Baronas E.,Godbout K.,Gosselin M.,Stagliano N.,Donovan M.,Woolf B.,Robison K.,Jeyaseelan R.,Breitbart R.E.,Acton S.
A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.
Circ. Res.
87
0-0
2000
249320
Tipnis S.R.,Hooper N.M.,Hyde R.,Karran E.,Christie G.,Turner A.J.
A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.
J. Biol. Chem.
275
33238-33243
2000
249321
Eyries M.,Michaud A.,Deinum J.,Agrapart M.,Chomilier J.,Kramers C.,Soubrier F.
Increased shedding of angiotensin-converting enzyme by a mutation identified in the stalk region.
J. Biol. Chem.
276
5525-5532
2001
249322
Kohlstedt K.,Shoghi F.,Mueller-Esterl W.,Busse R.,Fleming I.
CK2 phosphorylates the angiotensin-converting enzyme and regulates its retention in the endothelial cell plasma membrane.
Circ. Res.
91
749-756
2002
249323
Harmer D.,Gilbert M.,Borman R.,Clark K.L.
Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme.
FEBS Lett.
532
107-110
2002
249324
Gordon K.,Redelinghuys P.,Schwager S.L.U.,Ehlers M.R.W.,Papageorgiou A.C.,Natesh R.,Acharya K.R.,Sturrock E.D.
Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme.
Biochem. J.
371
437-442
2003
249325
Goulter A.B.,Goddard M.J.,Allen J.C.,Clark K.L.
ACE2 gene expression is up-regulated in the human failing heart.
BMC Med.
2
19-19
2004
249326
Burrell L.M.,Risvanis J.,Kubota E.,Dean R.G.,MacDonald P.S.,Lu S.,Tikellis C.,Grant S.L.,Lew R.A.,Smith A.I.,Cooper M.E.,Johnston C.I.
Myocardial infarction increases ACE2 expression in rat and humans.
Eur. Heart J.
26
369-375
2005
249327
Liu T.,Qian W.-J.,Gritsenko M.A.,Camp D.G. II,Monroe M.E.,Moore R.J.,Smith R.D.
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
J. Proteome Res.
4
2070-2080
2005
249328
Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
J. Proteome Res.
8
651-661
2009
249329
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
249330
Natesh R.,Schwager S.L.U.,Sturrock E.D.,Acharya K.R.
Crystal structure of the human angiotensin-converting enzyme-lisinopril complex.
Nature
421
551-554
2003
249331
Natesh R.,Schwager S.L.U.,Evans H.R.,Sturrock E.D.,Acharya K.R.
Structural details on the binding of antihypertensive drugs captopril and enalaprilat to human testicular angiotensin I-converting enzyme.
Biochemistry
43
8718-8724
2004
249332
Corradi H.R.,Schwager S.L.U.,Nchinda A.T.,Sturrock E.D.,Acharya K.R.
Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design.
J. Mol. Biol.
357
964-974
2006
249333
Vleming L.J.,van der Pijl J.W.,Lemkes H.H.P.J.,Westendorp R.G.J.,Maassen J.A.,Daha M.R.,van Es L.A.,van Kooten C.
The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM.
Clin. Nephrol.
51
133-140
1999
249334
Halushka M.K.,Fan J.-B.,Bentley K.,Hsie L.,Shen N.,Weder A.,Cooper R.,Lipshutz R.,Chakravarti A.
Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.
Nat. Genet.
22
239-247
1999
249335
Kramers C.,Danilov S.M.,Deinum J.,Balyasnikova I.V.,Scharenborg N.,Looman M.,Boomsma F.,de Keijzer M.H.,van Duijn C.,Martin S.,Soubrier F.,Adema G.J.
Point mutation in the stalk of angiotensin-converting enzyme causes a dramatic increase in serum angiotensin-converting enzyme but no cardiovascular disease.
Circulation
104
1236-1240
2001
249336
Linnebank M.,Kesper K.,Jeub M.,Urbach H.,Wuellner U.,Klockgether T.,Schmidt S.
Hereditary elevation of angiotensin converting enzyme suggesting neurosarcoidosis.
Neurology
61
1819-1820
2003
249337
Casas J.P.,Hingorani A.D.,Bautista L.E.,Sharma P.
Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls.
Arch. Neurol.
61
1652-1661
2004
249338
Slowik A.,Turaj W.,Dziedzic T.,Haefele A.,Pera J.,Malecki M.T.,Glodzik-Sobanska L.,Szermer P.,Figlewicz D.A.,Szczudlik A.
DD genotype of ACE gene is a risk factor for intracerebral hemorrhage.
Neurology
63
359-361
2004
249339
Gribouval O.,Gonzales M.,Neuhaus T.,Aziza J.,Bieth E.,Laurent N.,Bouton J.M.,Feuillet F.,Makni S.,Ben Amar H.,Laube G.,Delezoide A.-L.,Bouvier R.,Dijoud F.,Ollagnon-Roman E.,Roume J.,Joubert M.,Antignac C.,Gubler M.-C.
Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.
Nat. Genet.
37
964-968
2005
249340
Cromer M.K.,Choi M.,Nelson-Williams C.,Fonseca A.L.,Kunstman J.W.,Korah R.M.,Overton J.D.,Mane S.,Kenney B.,Malchoff C.D.,Stalberg P.,Akerstroem G.,Westin G.,Hellman P.,Carling T.,Bjoerklund P.,Lifton R.P.
Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.
Proc. Natl. Acad. Sci. U.S.A.
112
4062-4067
2015