Sequence of TDT_HUMAN
EC Number:2.7.7.31
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1
Other sequences found for EC No. 2.7.7.31
General information:
Sequence
0 MDPPRASHLS PRKKRPRQTG ALMASSPQDI KFQDLVVFIL EKKMGTTRRA FLMELARRKG
60 FRVENELSDS VTHIVAENNS GSDVLEWLQA QKVQVSSQPE LLDVSWLIEC IRAGKPVEMT
120 GKHQLVVRRD YSDSTNPGPP KTPPIAVQKI SQYACQRRTT LNNCNQIFTD AFDILAENCE
180 FRENEDSCVT FMRAASVLKS LPFTIISMKD TEGIPCLGSK VKGIIEEIIE DGESSEVKAV
240 LNDERYQSFK LFTSVFGVGL KTSEKWFRMG FRTLSKVRSD KSLKFTRMQK AGFLYYEDLV
300 SCVTRAEAEA VSVLVKEAVW AFLPDAFVTM TGGFRRGKKM GHDVDFLITS PGSTEDEEQL
360 LQKVMNLWEK KGLLLYYDLV ESTFEKLRLP SRKVDALDHF QKCFLIFKLP RQRVDSDQSS
420 WQEGKTWKAI RVDLVLCPYE RRAFALLGWT GSRQFERDLR RYATHERKMI LDNHALYDKT
480 KRIFLKAESE EEIFAHLGLD YIEPWERNA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
239937
Peterson R.C.,Cheung L.C.,Mattaliano R.J.,White S.T.,Chang L.M.S.,Bollum F.J.
Expression of human terminal deoxynucleotidyl transferase in Escherichia coli.
J. Biol. Chem.
260
10495-10502
1985
239938
Riley L.K.,Morrow J.K.,Danton M.J.,Coleman M.S.
Human terminal deoxyribonucleotidyltransferase: molecular cloning and structural analysis of the gene and 5' flanking region.
Proc. Natl. Acad. Sci. U.S.A.
85
2489-2493
1988
239939
Ibe S.,Fujita K.,Toyomoto T.,Shimazaki N.,Kaneko R.,Tanabe A.,Takebe I.,Kuroda S.,Kobayashi T.,Toji S.,Tamai K.,Yamamoto H.,Koiwai O.
Terminal deoxynucleotidyltransferase is negatively regulated by direct interaction with proliferating cell nuclear antigen.
Genes Cells
6
815-824
2001
239941
Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.
The DNA sequence and comparative analysis of human chromosome 10.
Nature
429
375-381
2004
239942
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
239943
Koiwai O.,Morita A.
Isolation of putative promoter region for human terminal deoxynucleotidyltransferase gene.
Biochem. Biophys. Res. Commun.
154
91-100
1988
239944
Peterson R.C.,Cheung L.C.,Mattaliano R.J.,Chang L.M.S.,Bollum F.J.
Molecular cloning of human terminal deoxynucleotidyltransferase.
Proc. Natl. Acad. Sci. U.S.A.
81
4363-4367
1984
239945
Yang B.,Gathy K.N.,Coleman M.S.
Mutational analysis of residues in the nucleotide binding domain of human terminal deoxynucleotidyl transferase.
J. Biol. Chem.
269
11859-11868
1994
239946
Yamashita N.,Shimazaki N.,Ibe S.,Kaneko R.,Tanabe A.,Toyomoto T.,Fujita K.,Hasegawa T.,Toji S.,Tamai K.,Yamamoto H.,Koiwai O.
Terminal deoxynucleotidyltransferase directly interacts with a novel nuclear protein that is homologous to p65.
Genes Cells
6
641-652
2001
239947
Fujita K.,Shimazaki N.,Ohta Y.,Kubota T.,Ibe S.,Toji S.,Tamai K.,Fujisaki S.,Hayano T.,Koiwai O.
Terminal deoxynucleotidyltransferase forms a ternary complex with a novel chromatin remodeling protein with 82 kDa and core histone.
Genes Cells
8
559-571
2003
239948
Mahajan K.N.,Mitchell B.S.
Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase.
Proc. Natl. Acad. Sci. U.S.A.
100
10746-10751
2003
239949
Fujisaki S.,Sato A.,Toyomoto T.,Hayano T.,Sugai M.,Kubota T.,Koiwai O.
Direct binding of TReP-132 with TdT results in reduction of TdT activity.
Genes Cells
11
47-57
2006
