Sequence of DAPE_HAEIN
EC Number:3.5.1.18
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
succinyl-diaminopimelate desuccinylase
P44514
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
377
41353
Reaction
N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate
Other sequences found for EC No. 3.5.1.18
General information:
Sequence
0 MKEKVVSLAQ DLIRRPSISP NDEGCQQIIA ERLEKLGFQI EWMPFNDTLN LWAKHGTSEP
60 VIAFAGHTDV VPTGDENQWS SPPFSAEIID GMLYGRGAAD MKGSLAAMIV AAEEYVKANP
120 NHKGTIALLI TSDEEATAKD GTIHVVETLM ARDEKITYCM VGEPSSAKNL GDVVKNGRRG
180 SITGNLYIQG IQGHVAYPHL AENPIHKAAL FLQELTTYQW DKGNEFFPPT SLQIANIHAG
240 TGSNNVIPAE LYIQFNLRYC TEVTDEIIKQ KVAEMLEKHN LKYRIEWNLS GKPFLTKPGK
300 LLDSITSAIE ETIGITPKAE TGGGTSDGRF IALMGAEVVE FGPLNSTIHK VNECVSVEDL
360 GKCGEIYHKM LVNLLDS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
23748
Fleischmann R.D.,Adams M.D.,White O.,Clayton R.A.,Kirkness E.F.,Kerlavage A.R.,Bult C.J.,Tomb J.-F.,Dougherty B.A.,Merrick J.M.,McKenney K.,Sutton G.G.,FitzHugh W.,Fields C.A.,Gocayne J.D.,Scott J.D.,Shirley R.,Liu L.-I.,Glodek A.,Kelley J.M.,Weidman J.F.,Phillips C.A.,Spriggs T.,Hedblom E.,Cotton M.D.,Utterback T.R.,Hanna M.C.,Nguyen D.T.,Saudek D.M.,Brandon R.C.,Fine L.D.,Fritchman J.L.,Fuhrmann J.L.,Geoghagen N.S.M.,Gnehm C.L.,McDonald L.A.,Small K.V.,Fraser C.M.,Smith H.O.,Venter J.C.
Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.
Science
269
496-512
1995
23749
Born T.L.,Zheng R.,Blanchard J.S.
Hydrolysis of N-succinyl-L,L-diaminopimelic acid by the Haemophilus influenzae dapE-encoded desuccinylase: metal activation, solvent isotope effects, and kinetic mechanism.
Biochemistry
37
10478-10487
1998
23750
Bienvenue D.L.,Gilner D.M.,Davis R.S.,Bennett B.,Holz R.C.
Substrate specificity, metal binding properties, and spectroscopic characterization of the DapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae.
Biochemistry
42
10756-10763
2003
23751
Cosper N.J.,Bienvenue D.L.,Shokes J.E.,Gilner D.M.,Tsukamoto T.,Scott R.A.,Holz R.C.
The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae is a dinuclear metallohydrolase.
J. Am. Chem. Soc.
125
14654-14655
2003
23752
Davis R.,Bienvenue D.,Swierczek S.I.,Gilner D.M.,Rajagopal L.,Bennett B.,Holz R.C.
Kinetic and spectroscopic characterization of the E134A- and E134D-altered dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae.
J. Biol. Inorg. Chem.
11
206-216
2006
23753
Gillner D.M.,Bienvenue D.L.,Nocek B.P.,Joachimiak A.,Zachary V.,Bennett B.,Holz R.C.
The dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase from Haemophilus influenzae contains two active-site histidine residues.
J. Biol. Inorg. Chem.
14
1-10
2009
23754
Uda N.R.,Creus M.
Selectivity of inhibition of N-succinyl-L,L-diaminopimelic acid desuccinylase in bacteria: The product of dapE-gene is not the target of L-captopril antimicrobial activity.
Bioinorg. Chem. Appl.
2011
306465-306465
2011
23755
Nocek B.P.,Gillner D.M.,Fan Y.,Holz R.C.,Joachimiak A.
Structural basis for catalysis by the mono- and dimetalated forms of the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase.
J. Mol. Biol.
397
617-626
2010
