Sequence of DAPA_ECOLI
EC Number:4.3.3.7
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O
Other sequences found for EC No. 4.3.3.7
General information:
Sequence
0 MFTGSIVAIV TPMDEKGNVC RASLKKLIDY HVASGTSAIV SVGTTGESAT LNHDEHADVV
60 MMTLDLADGR IPVIAGTGAN ATAEAISLTQ RFNDSGIVGC LTVTPYYNRP SQEGLYQHFK
120 AIAEHTDLPQ ILYNVPSRTG CDLLPETVGR LAKVKNIIGI KEATGNLTRV NQIKELVSDD
180 FVLLSGDDAS ALDFMQLGGH GVISVTANVA ARDMAQMCKL AAEGHFAEAR VINQRLMPLH
240 NKLFVEPNPI PVKWACKELG LVATDTLRLP MTPITDSGRE TVRAALKHAG LL
Download this sequence
in fasta formatDownload all sequences for 4.3.3.7
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
23540
Richaud F.,Richaud C.,Ratet P.,Patte J.-C.
Chromosomal location and nucleotide sequence of the Escherichia coli dapA gene.
J. Bacteriol.
166
297-300
1986
23541
Yamamoto Y.,Aiba H.,Baba T.,Hayashi K.,Inada T.,Isono K.,Itoh T.,Kimura S.,Kitagawa M.,Makino K.,Miki T.,Mitsuhashi N.,Mizobuchi K.,Mori H.,Nakade S.,Nakamura Y.,Nashimoto H.,Oshima T.,Oyama S.,Saito N.,Sampei G.,Satoh Y.,Sivasundaram S.,Tagami H.,Takahashi H.,Takeda J.,Takemoto K.,Uehara K.,Wada C.,Yamagata S.,Horiuchi T.
Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.
DNA Res.
4
91-113
1997
23542
Blattner F.R.,Plunkett G. III,Bloch C.A.,Perna N.T.,Burland V.,Riley M.,Collado-Vides J.,Glasner J.D.,Rode C.K.,Mayhew G.F.,Gregor J.,Davis N.W.,Kirkpatrick H.A.,Goeden M.A.,Rose D.J.,Mau B.,Shao Y.
The complete genome sequence of Escherichia coli K-12.
Science
277
1453-1462
1997
23543
Hayashi K.,Morooka N.,Yamamoto Y.,Fujita K.,Isono K.,Choi S.,Ohtsubo E.,Baba T.,Wanner B.L.,Mori H.,Horiuchi T.
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
Mol. Syst. Biol.
2
0-0
2006
23545
Link A.J.,Robison K.,Church G.M.
Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Electrophoresis
18
1259-1313
1997
23546
Wilkins M.R.,Gasteiger E.,Tonella L.,Ou K.,Tyler M.,Sanchez J.-C.,Gooley A.A.,Walsh B.J.,Bairoch A.,Appel R.D.,Williams K.L.,Hochstrasser D.F.
Protein identification with N and C-terminal sequence tags in proteome projects.
J. Mol. Biol.
278
599-608
1998
23547
Laber B.,Gomis-Rueth F.-X.,Romao M.J.,Huber R.
Escherichia coli dihydrodipicolinate synthase. Identification of the active site and crystallization.
Biochem. J.
288
691-695
1992
23548
Tiedemann A.A.,Demarini D.J.,Parker J.,Smith J.M.
DNA sequence of the purC gene encoding 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide synthetase and organization of the dapA-purC region of Escherichia coli K-12.
J. Bacteriol.
172
6035-6041
1990
23549
Bouvier J.,Pugsley A.P.,Stragier P.
A gene for a new lipoprotein in the dapA-purC interval of the Escherichia coli chromosome.
J. Bacteriol.
173
5523-5531
1991
23550
VanBogelen R.A.,Abshire K.Z.,Moldover B.,Olson E.R.,Neidhardt F.C.
Escherichia coli proteome analysis using the gene-protein database.
Electrophoresis
18
1243-1251
1997
23551
Karsten W.E.
Dihydrodipicolinate synthase from Escherichia coli: pH dependent changes in the kinetic mechanism and kinetic mechanism of allosteric inhibition by L-lysine.
Biochemistry
36
1730-1739
1997
23552
Dobson R.C.,Gerrard J.A.,Pearce F.G.
Dihydrodipicolinate synthase is not inhibited by its substrate, (S)-aspartate beta-semialdehyde.
Biochem. J.
377
757-762
2004
23553
Boughton B.A.,Griffin M.D.,O'Donnell P.A.,Dobson R.C.,Perugini M.A.,Gerrard J.A.,Hutton C.A.
Irreversible inhibition of dihydrodipicolinate synthase by 4-oxo-heptenedioic acid analogues.
Bioorg. Med. Chem.
16
9975-9983
2008
23554
Devenish S.R.,Blunt J.W.,Gerrard J.A.
NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase.
J. Med. Chem.
53
4808-4812
2010
23555
Boughton B.A.,Hor L.,Gerrard J.A.,Hutton C.A.
1,3-Phenylene bis(ketoacid) derivatives as inhibitors of Escherichia coli dihydrodipicolinate synthase.
Bioorg. Med. Chem.
20
2419-2426
2012
23556
Mirwaldt C.,Korndoerfer I.,Huber R.
The crystal structure of dihydrodipicolinate synthase from Escherichia coli at 2.5-A resolution.
J. Mol. Biol.
246
227-239
1995
23557
Blicking S.,Renner C.,Laber B.,Pohlenz H.-D.,Holak T.A.,Huber R.
Reaction mechanism of Escherichia coli dihydrodipicolinate synthase investigated by X-ray crystallography and NMR spectroscopy.
Biochemistry
36
24-33
1997
23558
Dobson R.C.J.,Valegaard K.,Gerrard J.A.
The crystal structure of three site-directed mutants of Escherichia coli dihydrodipicolinate synthase: further evidence for a catalytic triad.
J. Mol. Biol.
338
329-339
2004
23559
Dobson R.C.J.,Griffin M.D.W.,Jameson G.B.,Gerrard J.A.
The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological significance.
Acta Crystallogr. D
61
1116-1124
2005
23560
Dobson R.C.J.,Devenish S.R.A.,Turner L.A.,Clifford V.R.,Pearce F.G.,Jameson G.B.,Gerrard J.A.
Role of arginine 138 in the catalysis and regulation of Escherichia coli dihydrodipicolinate synthase.
Biochemistry
44
13007-13013
2005
23562
Devenish S.R.,Gerrard J.A.,Jameson G.B.,Dobson R.C.
The high-resolution structure of dihydrodipicolinate synthase from Escherichia coli bound to its first substrate, pyruvate.
Acta Crystallogr. F
64
1092-1095
2008
23563
Pearce F.G.,Dobson R.C.,Weber A.,Lane L.A.,McCammon M.G.,Squire M.A.,Perugini M.A.,Jameson G.B.,Robinson C.V.,Gerrard J.A.
Mutating the tight-dimer interface of dihydrodipicolinate synthase disrupts the enzyme quaternary structure: toward a monomeric enzyme.
Biochemistry
47
12108-12117
2008
23564
Griffin M.D.,Dobson R.C.,Pearce F.G.,Antonio L.,Whitten A.E.,Liew C.K.,Mackay J.P.,Trewhella J.,Jameson G.B.,Perugini M.A.,Gerrard J.A.
Evolution of quaternary structure in a homotetrameric enzyme.
J. Mol. Biol.
380
691-703
2008
23565
Dobson R.C.,Griffin M.D.,Devenish S.R.,Pearce F.G.,Hutton C.A.,Gerrard J.A.,Jameson G.B.,Perugini M.A.
Conserved main-chain peptide distortions: a proposed role for Ile203 in catalysis by dihydrodipicolinate synthase.
Protein Sci.
17
2080-2090
2008
23566
Dobson R.C.,Perugini M.A.,Jameson G.B.,Gerrard J.A.
Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis.
Biochimie
91
1036-1044
2009
23567
Soares da Costa T.P.,Muscroft-Taylor A.C.,Dobson R.C.,Devenish S.R.,Jameson G.B.,Gerrard J.A.
How essential is the 'essential' active-site lysine in dihydrodipicolinate synthase?
Biochimie
92
837-845
2010
23568
Boughton B.A.,Dobson R.C.,Hutton C.A.
The crystal structure of dihydrodipicolinate synthase from Escherichia coli with bound pyruvate and succinic acid semialdehyde: unambiguous resolution of the stereochemistry of the condensation product.
Proteins
80
2117-2122
2012
