Sequence of CBPC5_XENTR
EC Number:3.4.17.24
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
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Reaction
This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins. The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions. In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17, tubulinyl-Tyr carboxypeptidase). The latter is cleaved to delta2-tubulin and further to delta3-tubulin.
General information:
Sequence
0 MEVRCGGLLF SSKFDSGNLA RVEKVEKPGA EGDAFSGSVS GGSVPTPDYE FNIWTKPDCA
60 ETEYENGNRS WFYFSVRFGA PGKLIKINIM NMNKQSKLYS QGMAPFVRTV PIRSRWERIR
120 DRPTFEMVEN QFILSFVHRF LDCRGSTTYF AFCFPFSYEE SQELMAGLDD RFSDCKNITP
180 GSFPDSIYYH RELLCHSLDG LRVDLLTISS CHGMTEEREP RLDKLFPDRS TPRPYRFTGK
240 RVYFLSSRVH PGETPSSFVF NGFLEFILRQ DDPRAQMLRR MFVFKLIPML NPDGVVRGHY
300 RTDSRGVNLN RQYLNPDFEL HPSVYAAKTV LLYHHVYNSV GPNDPDWRTS VSLQTSNISL
360 CPKTSNHSLK DLPLEDSLSE LEKANNLLNS MEKEECYITC PQAVTQGAPP ENDPNFLSDS
420 RDFIRQRDVF ILESDTEPKD IYSHSGSSQP TIFTKSIPPQ ESGIAFYVDL HGHASKRGCF
480 MYGNYFTEEN DQVENMLYPK LISLNSANFD FLACNFSEKN MYAKDKRDGQ SKEGSGRVAI
540 HKATGIIHSY TLECNYNTGR CVNSIPAACH DCGRASPPPP PAFPPKYTTQ VFEQIGRAVA
600 TAALDMAECN PWPRLIMSEY NNLTNLRAWM LKHLRNTKGV LPGTLKKKST KSPVKASSLT
660 SGSLSENSLI RTRSYSNSTA STNSQQNSPQ IKPSINFTFL CSSSNHSPPK VSQRVLGPVR
720 ETKAQEKRRQ QSLLRSSVRS PTACQQRLST QAPSLSSGYP KTSSHAKTSC PLSLSLSMSG
780 SGFSGLSQAA KVKNGTKKNN LEGDSTRQHI HQGHGIALLQ NMQKRGSSHN NAEYSKSLES
840 LGVRPSRIPV RRNGLLTNEK ESPILRVWKY TTDTSLKHCS LADLAAVTSS LTVCSVPLLK
900 SKAEEPVFIC EATKETADQH FPAVSQDAAH LSAYQSVLSF CSEA
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