Sequence of POLG_AIVA8
EC Number:3.4.22.28
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Selective cleavage of Gln-/-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly
Other sequences found for EC No. 3.4.22.28
General information:
Sequence
0 MAATRVSRSV LAAVAHSAAH RTYHTVLDCY DRLYLNTNPH LSYPLPKNSS FPCPFCQYDE
60 QNEVLSPESL RGEGAEPCWK CSQDKPRRKY NTTPPEDWLY DSDVQSWFYP ETYYSDLQQK
120 FFDKLALLSL PGAYQAKTPE ERALAGALTQ LLNFPSTPPL TLPTTNLQRQ GNSVTNIYGN
180 GNNVTTDVGA NGWAPTVSTG LGDGPVSASA DSLPGRSGGA SSEKTHTVSG SSNKVGSRFS
240 KWWEPAAARA SESATDSAIE GIDAAGKAAS KAITRKLDRP AAPSSTANPQ PSLIALNPSA
300 TQSGNASILT GSTAPSLLAY PTATPVPLPN PDEPSQPGPS GDRTWLLDTV TWSQEFTRGW
360 NIAGSNGMQW TGLESLIFPV STDTNWTSTS SPTAYPLPFS FVRAYPDSSW AAMYNTHSMW
420 NCGWRVQVTV NGSQFHAGAL ILYMVPEATT HAIQTARDNA GFVFPYVILN LYESNTATIE
480 VPYISPTPNT SSGLHAPWTF YLQVLSPLNP PPSLPTSLSC SIYVTPVDSS FHGLRYLAPQ
540 HWKTRAVPGA GTFGSAVAGQ ELPLCGVRAY YPPNAYIPAQ VRDWLEFAHR PGLMATVPWT
600 MADEPAERLG IFPVSPSAIA GTGAPISYVI SLFSQWRGEL AAHLLFTGSA QHYGRLVVCY
660 TPAAPQPPST MQEAMRGTYT VWDVNAASTL EFTIPFISNS YWKTVDVNNP DALLSTTGYV
720 SIWVQNPLVG PHTAPASALV QAFISAGESF NVRLMQNPAL TSQTLTEDLD APQDTGNIEN
780 GAADNSPQPR TTFDYTGNPL PPDTKLENFF SFYRLLPMGG SGAPSLSFPA DEGTIIPLNP
840 INWLKGADVS GIAAMLSCFT YIAADLRITL RFSNPNDNPA TMLVAFAPPG ATIPLKPTRQ
900 MLSNFYMAEV PVSAATSTMV SFSIPYTSPL SAIPTSYFGW EDWSGTNFGQ LSSGSWGNLM
960 LIPSLSVDSA IPFDFQLSCW VAFGNFKAWV PRPPPPLPPL PTPAANAERT VAVIKQGAAS
1020 ATPDVDPDDR VYIVRAQRPT YVHWAIRKVA PDGSAKQISL SRSGIQALVA LEPPEGEPYL
1080 EILPSHWTLA ELQLGNKWEY SATNNCTHFV SSITGESLPN TGFSLALGIG ALTAIAASAA
1140 VAVKALPGIR RQGLLTLSAD TETNQTLNKI TESVNQAAQV VSQFDLSGPA NSVSLAASDI
1200 REAAHKVASS LNGFTDVIAD IKDSLFTRVS DAVESGVATF LTWLVKLFGY LLVLFGSPTP
1260 MSISGLLVII CADLAPHARE FFTASGNVLS SLYYWIASKL GLSVTPQECE RATLEPQGLK
1320 DFNDGALAMR NVEWIGETAW KWAHRLLDWI RGKAKTDPQA KLADVHDEIM LHYSDSILAL
1380 GSEKLPIDHI TKSISRCREL VSIAQEAKSG PHSSFLNQAI KNYTLAISQH RKCQTGPRPE
1440 PVVVYLYGPP GTGKSLLASL LAQTLSQRLA GTPDDVYSPS SASCEYFDGY TGQTVHFIDD
1500 IGQDPEGRDW ANFPNLVSSA PFIVPMASLE EKGTHYTSKV IVVTSNFHEP NERAARSMGA
1560 LRRRVHLRIN VTSNGVPFDP TNALNPIPGT QSKYFTAQTP LTLFQSNTVR LDRDSIWTPT
1620 FTNMDELVDA IVTRLDRSTG VSNSLASLIR RQGNRVIDAE PREIPLEYAD DLLEAMAHHR
1680 PVPCSLGLSQ AIANNTPIQQ ISETFWKYRK PIFTCTTFLA VLGFLCSVIP LARSLWKSKQ
1740 DTPQEPQAAY SAISHQKPKP KSQKPVPTRH IQRQGISPAV PGISNNVVHV ESGNGLNKNV
1800 MSGFYIFSRF LLVPTHLREP HHTTLTVGAD TYDWATLQTQ EFGEITIVHT PTSRQYKDMR
1860 RFIGAHPHPT GLLVSQFKAA PLYVRISDNR ILDLDFPGVV VCKQAYGYRA ATFEGLCGSP
1920 LVTDDPSGVK ILGLHVAGVA GTSGFSAPIH PILGQITQFA TTQQSLIVPT AEVRPGVNVN
1980 RMSRLHPSPA YGAFPVKKQP APLKRNDKRL QEGVDLDTQL FLKHGKGDVT EPWPGLEAAA
2040 DLYFSTFPTS LPVLTQEQAI HGTPNMEGLD MGQAAGYPWN TLGRSRRSLF DEVEPGVFVP
2100 KPELQAEINQ TLEDPDYVYS TFLKDELRPT AKVEQGLTRI VEAAPIHAIV AGRMLLGGLI
2160 DYMQGRPGEH GSAVGCNPDV HWTSFFYAFS EFSQVYDLDY KCFDATLPSA VFTLVADHLT
2220 RITGDPRVGR YIHSIRHSHH IYGNRMYDMI GGNPSGCVAT SILNTIINNI CVLSALIQHP
2280 DFSPSRFHIL AYGDDVIYAT EPPIHPSFLR EFYQKHTPLV VTPANKGQDF PPTSTIYEVT
2340 FLKRWFVPDD VRPIYIHPVM DPDTYEQSVM WLRDGDFQDV VTSLCHLAFH SGPKTYAAWC
2400 MKVREQCLKS GFAPNFLPYS YLQLRWLNLL AA
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
207371
Yamashita T.,Sakae K.,Tsuzuki H.,Suzuki Y.,Ishikawa N.,Takeda N.,Miyamura T.,Yamazaki S.
Complete nucleotide sequence and genetic organization of Aichi virus, a distinct member of the Picornaviridae associated with acute gastroenteritis in humans.
J. Virol.
72
8408-8412
1998
207372
Sasaki J.,Kusuhara Y.,Maeno Y.,Kobayashi N.,Yamashita T.,Sakae K.,Takeda N.,Taniguchi K.
Construction of an infectious cDNA clone of Aichi virus (a new member of the family Picornaviridae) and mutational analysis of a stem-loop structure at the 5' end of the genome.
J. Virol.
75
8021-8030
2001
207373
Sasaki J.,Nagashima S.,Taniguchi K.
Aichi virus leader protein is involved in viral RNA replication and encapsidation.
J. Virol.
77
10799-10807
2003
207374
Sasaki J.,Taniguchi K.
Aichi virus 2A protein is involved in viral RNA replication.
J. Virol.
82
9765-9769
2008
207375
Ishikawa K.,Sasaki J.,Taniguchi K.
Overall linkage map of the nonstructural proteins of Aichi virus.
Virus Res.
147
77-84
2010
207376
Sasaki J.,Ishikawa K.,Taniguchi K.
3CD, but not 3C, cleaves the VP1/2A site efficiently during Aichi virus polyprotein processing through interaction with 2A.
Virus Res.
163
592-598
2012
207377
Sasaki J.,Ishikawa K.,Arita M.,Taniguchi K.
ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites.
EMBO J.
31
754-766
2012
207378
Greninger A.L.,Knudsen G.M.,Betegon M.,Burlingame A.L.,Derisi J.L.
The 3A protein from multiple picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIbeta.
J. Virol.
86
3605-3616
2012
207379
Greninger A.L.,Knudsen G.M.,Betegon M.,Burlingame A.L.,DeRisi J.L.
ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.
MBio
4
0-0
2013
207380
Ishikawa-Sasaki K.,Sasaki J.,Taniguchi K.
A complex comprising phosphatidylinositol 4-kinase IIIbeta, ACBD3, and Aichi virus proteins enhances phosphatidylinositol 4-phosphate synthesis and is critical for formation of the viral replication complex.
J. Virol.
88
6586-6598
2014
207381
McPhail J.A.,Ottosen E.H.,Jenkins M.L.,Burke J.E.
The molecular basis of Aichi virus 3A protein activation of phosphatidylinositol 4 kinase IIIbeta, PI4KB, through ACBD3.
Structure
25
121-131
2017
207382
Lyoo H.,van der Schaar H.M.,Dorobantu C.M.,Rabouw H.H.,Strating J.R.P.M.,van Kuppeveld F.J.M.
ACBD3 is an essential pan-enterovirus host factor that mediates the interaction between viral 3A protein and cellular protein PI4KB.
MBio
10
0-0
2019
207383
Sabin C.,Plevka P.
The use of noncrystallographic symmetry averaging to solve structures from data affected by perfect hemihedral twinning.
Acta Crystallogr. F Struct. Biol. Commun.
72
188-197
2016
207384
Sabin C.,Fuzik T.,Skubnik K.,Palkova L.,Lindberg A.M.,Plevka P.
Structure of Aichi virus 1 and its empty particle: clues towards kobuvirus genome release mechanism.
J. Virol.
90
10800-10810
2016
207385
Zhu L.,Wang X.,Ren J.,Kotecha A.,Walter T.S.,Yuan S.,Yamashita T.,Tuthill T.J.,Fry E.E.,Rao Z.,Stuart D.I.
Structure of human Aichi virus and implications for receptor binding.
Nat. Microbiol.
1
16150-16150
2016
207386
Klima M.,Chalupska D.,Rozycki B.,Humpolickova J.,Rezabkova L.,Silhan J.,Baumlova A.,Dubankova A.,Boura E.
Kobuviral Non-structural 3A Proteins Act as Molecular Harnesses to Hijack the Host ACBD3 Protein.
Structure
25
219-230
2017
