Sequence of PHLC1_CLOPE
EC Number:3.1.4.3
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a phosphatidylcholine + H2O = 1,2-diacyl-sn-glycerol + phosphocholine
Other sequences found for EC No. 3.1.4.3
General information:
Sequence
0 MKRKICKALI CATLATSLWA GASTKVYAWD GKIDGTGTHA MIVTQGVSIL ENDLSKNEPE
60 SVRKNLEILK ENMHELQLGS TYPDYDKNAY DLYQDHFWDP DTDNNFSKDN SWYLAYSIPD
120 TGESQIRKFS ALARYEWQRG NYKQATFYLG EAMHYFGDID TPYHPANVTA VDSAGHVKFE
180 TFAEERKEQY KINTAGCKTN EDFYADILKN KDFNAWSKEY ARGFAKTGKS IYYSHASMSH
240 SWDDWDYAAK VTLANSQKGT AGYIYRFLHD VSEGNDPSVG KNVKELVAYI STSGEKDAGT
300 DDYMYFGIKT KDGKTQEWEM DNPGNDFMTG SKDTYTFKLK DENLKIDDIQ NMWIRKRKYT
360 AFPDAYKPEN IKIIANGKVV VDKDINEWIS GNSTYNIK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
204948
Saint-Joanis B.,Garnier T.,Cole S.T.
Gene cloning shows the alpha-toxin of Clostridium perfringens to contain both sphingomyelinase and lecithinase activities.
Mol. Gen. Genet.
219
453-460
1989
204949
Katayama S.,Matsushita O.,Minami J.,Mizobuchi S.,Okabe A.
Comparison of the alpha-toxin genes of Clostridium perfringens type A and C strains: evidence for extragenic regulation of transcription.
Infect. Immun.
61
457-463
1993
204950
Tsutsui K.,Minami J.,Matsushita O.,Katayama S.,Taniguchi Y.,Nakamura S.,Nishioka M.,Okabe A.
Phylogenetic analysis of phospholipase C genes from Clostridium perfringens types A to E and Clostridium novyi.
J. Bacteriol.
177
7164-7170
1995
204951
Ginter A.,Williamson E.D.,Dessy F.,Coppe P.,Bullifent H.,Howells A.M.,Titball R.W.
Molecular variation between the alpha-toxins from the type strain (NCTC 8237) and clinical isolates of Clostridium perfringens associated with disease in man and animals.
Microbiology
142
191-198
1996
204952
Kameyama K.,Matsushita O.,Katayama S.,Minami J.,Maeda M.,Nakamura S.,Okabe A.
Analysis of the phospholipase C gene of Clostridium perfringens KZ1340 isolated from Antarctic soil.
Microbiol. Immunol.
40
255-263
1996
204953
Shimizu T.,Ohtani K.,Hirakawa H.,Ohshima K.,Yamashita A.,Shiba T.,Ogasawara N.,Hattori M.,Kuhara S.,Hayashi H.
Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater.
Proc. Natl. Acad. Sci. U.S.A.
99
996-1001
2002
204954
Guillouard I.,Garnier T.,Cole S.T.
Use of site-directed mutagenesis to probe structure-function relationships of alpha-toxin from Clostridium perfringens.
Infect. Immun.
64
2440-2444
1996
204955
Guillouard I.,Alzari P.M.,Saliou B.,Cole S.T.
The carboxy-terminal C2-like domain of the alpha-toxin from Clostridium perfringens mediates calcium-dependent membrane recognition.
Mol. Microbiol.
26
867-876
1997
204956
Macfarlane M.G.,Knight B.C.J.G.
The biochemistry of bacterial toxins. I. The lecithinase activity of Cl.welchii toxins.
Biochem. J.
35
884-902
1941
204957
Ellemor D.M.,Baird R.N.,Awad M.M.,Boyd R.L.,Rood J.I.,Emmins J.J.
Use of genetically manipulated strains of Clostridium perfringens reveals that both alpha-toxin and theta-toxin are required for vascular leukostasis to occur in experimental gas gangrene.
Infect. Immun.
67
4902-4907
1999
204958
Stevens D.L.,Tweten R.K.,Awad M.M.,Rood J.I.,Bryant A.E.
Clostridial gas gangrene: evidence that alpha and theta toxins differentially modulate the immune response and induce acute tissue necrosis.
J. Infect. Dis.
176
189-195
1997
204959
Titball R.W.,Naylor C.E.,Basak A.K.
The Clostridium perfringens alpha-toxin.
Anaerobe
5
51-64
1999
204960
Jepson M.,Titball R.W.
Structure and function of clostridial phospholipases C.
Microbes Infect.
2
1277-1284
2000
204961
Naylor C.E.,Eaton J.T.,Howells A.M.,Justin N.,Moss D.S.,Titball R.W.,Basak A.K.
Structure of the key toxin in gas gangrene.
Nat. Struct. Biol.
5
738-746
1998
204962
Eaton J.T.,Naylor C.E.,Howells A.M.,Moss D.S.,Titball R.W.,Basak A.K.
Crystal structure of the C. perfringens alpha-toxin with the active site closed by a flexible loop region.
J. Mol. Biol.
319
275-281
2002
