Sequence of PHHY_PSEAE

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
4-hydroxybenzoate 3-monooxygenase
P20586
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
394
44324
Reaction
4-hydroxybenzoate + NADPH + H+ + O2 = 3,4-dihydroxybenzoate + NADP+ + H2O
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MKTQVAIIGA GPSGLLLGQL LHKAGIDNVI LERQTPDYVL GRIRAGVLEQ GMVDLLREAG
 60 VDRRMARDGL VHEGVEIAFA GQRRRIDLKR LSGGKTVTVY GQTEVTRDLM EAREACGATT
120 VYQAAEVRLH DLQGERPYVT FERDGERLRL DCDYIAGCDG FHGISRQSIP AERLKVFERV
180 YPFGWLGLLA DTPPVSHELI YANHPRGFAL CSQRSATRSR YYVQVPLSEK VEDWSDERFW
240 TELKARLPSE VAEKLVTGPS LEKSIAPLRS FVVEPMQHGR LFLAGDAAHI VPPTGAKGLN
300 LAASDVSTLY RLLLKAYREG RGELLERYSA ICLRRIWKAE RFSWWMTSVL HRFPDTDAFS
360 QRIQQTELEY YLGSEAGLAT IAENYVGLPY EEIE
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
199114
Entsch B.,Nan Y.,Weaich K.,Scott K.F.
Sequence and organization of pobA, the gene coding for p-hydroxybenzoate hydroxylase, an inducible enzyme from Pseudomonas aeruginosa.
Gene
71
279-291
1988
199115
Stover C.K.,Pham X.-Q.T.,Erwin A.L.,Mizoguchi S.D.,Warrener P.,Hickey M.J.,Brinkman F.S.L.,Hufnagle W.O.,Kowalik D.J.,Lagrou M.,Garber R.L.,Goltry L.,Tolentino E.,Westbrock-Wadman S.,Yuan Y.,Brody L.L.,Coulter S.N.,Folger K.R.,Kas A.,Larbig K.,Lim R.M.,Smith K.A.,Spencer D.H.,Wong G.K.-S.,Wu Z.,Paulsen I.T.,Reizer J.,Saier M.H. Jr.,Hancock R.E.W.,Lory S.,Olson M.V.
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Nature
406
959-964
2000
199116
Entsch B.,Palfey B.A.,Ballou D.P.,Massey V.
Catalytic function of tyrosine residues in para-hydroxybenzoate hydroxylase as determined by the study of site-directed mutants.
J. Biol. Chem.
266
17341-17349
1991
199117
Lah M.S.,Palfey B.A.,Schreuder H.A.,Ludwig M.L.
Crystal structures of mutant Pseudomonas aeruginosa p-hydroxybenzoate hydroxylases: the Tyr201Phe, Tyr385Phe, and Asn300Asp variants.
Biochemistry
33
1555-1564
1994
199118
Gatti D.L.,Palfey B.A.,Lah M.S.,Entsch B.,Massey V.,Ballou D.P.,Ludwig M.L.
The mobile flavin of 4-OH benzoate hydroxylase.
Science
266
110-114
1994
199119
Gatti D.L.,Entsch B.,Ballou D.P.,Ludwig M.L.
pH-dependent structural changes in the active site of p-hydroxybenzoate hydroxylase point to the importance of proton and water movements during catalysis.
Biochemistry
35
567-578
1996
199120
Ortiz-Maldonado M.,Gatti D.,Ballou D.P.,Massey V.
Structure-function correlations of the reaction of reduced nicotinamide analogues with p-hydroxybenzoate hydroxylase substituted with a series of 8-substituted flavins.
Biochemistry
38
16636-16647
1999
199121
Wang J.,Ortiz-Maldonado M.,Entsch B.,Massey V.,Ballou D.,Gatti D.L.
Protein and ligand dynamics in 4-hydroxybenzoate hydroxylase.
Proc. Natl. Acad. Sci. U.S.A.
99
608-613
2002
199122
Cole L.J.,Gatti D.L.,Entsch B.,Ballou D.P.
Removal of a methyl group causes global changes in p-hydroxybenzoate hydroxylase.
Biochemistry
44
8047-8058
2005