Sequence of PA2G3_HUMAN
EC Number:3.1.1.4
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
Other sequences found for EC No. 3.1.1.4
General information:
Sequence
0 MGVQAGLFGM LGFLGVALGG SPALRWYRTS CHLTKAVPGN PLGYLSFLAK DAQGLALIHA
60 RWDAHRRLQS CSWEDEPELT AAYGALCAHE TAWGSFIHTP GPELQRALAT LQSQWEACRA
120 LEESPAGARK KRAAGQSGVP GGGHQREKRG WTMPGTLWCG VGDSAGNSSE LGVFQGPDLC
180 CREHDRCPQN ISPLQYNYGI RNYRFHTISH CDCDTRFQQC LQNQHDSISD IVGVAFFNVL
240 EIPCFVLEEQ EACVAWYWWG GCRMYGTVPL ARLQPRTFYN ASWSSRATSP TPSSRSPAPP
300 KPRQKQHLRK GPPHQKGSKR PSKANTTALQ DPMVSPRLDV APTGLQGPQG GLKPQGARWV
360 CRSFRRHLDQ CEHQIGPREI EFQLLNSAQE PLFHCNCTRR LARFLRLHSP PEVTNMLWEL
420 LGTTCFKLAP PLDCVEGKNC SRDPRAIRVS ARHLRRLQQR RHQLQDKGTD ERQPWPSEPL
480 RGPMSFYNQC LQLTQAARRP DRQQKSWSQ
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
201052
Valentin E.,Ghomashchi F.,Gelb M.H.,Lazdunski M.,Lambeau G.
Novel human secreted phospholipase A2 with homology to the group III bee venom enzyme.
J. Biol. Chem.
275
7492-7496
2000
201053
Dunham I.,Hunt A.R.,Collins J.E.,Bruskiewich R.,Beare D.M.,Clamp M.,Smink L.J.,Ainscough R.,Almeida J.P.,Babbage A.K.,Bagguley C.,Bailey J.,Barlow K.F.,Bates K.N.,Beasley O.P.,Bird C.P.,Blakey S.E.,Bridgeman A.M.,Buck D.,Burgess J.,Burrill W.D.,Burton J.,Carder C.,Carter N.P.,Chen Y.,Clark G.,Clegg S.M.,Cobley V.E.,Cole C.G.,Collier R.E.,Connor R.,Conroy D.,Corby N.R.,Coville G.J.,Cox A.V.,Davis J.,Dawson E.,Dhami P.D.,Dockree C.,Dodsworth S.J.,Durbin R.M.,Ellington A.G.,Evans K.L.,Fey J.M.,Fleming K.,French L.,Garner A.A.,Gilbert J.G.R.,Goward M.E.,Grafham D.V.,Griffiths M.N.D.,Hall C.,Hall R.E.,Hall-Tamlyn G.,Heathcott R.W.,Ho S.,Holmes S.,Hunt S.E.,Jones M.C.,Kershaw J.,Kimberley A.M.,King A.,Laird G.K.,Langford C.F.,Leversha M.A.,Lloyd C.,Lloyd D.M.,Martyn I.D.,Mashreghi-Mohammadi M.,Matthews L.H.,Mccann O.T.,Mcclay J.,Mclaren S.,McMurray A.A.,Milne S.A.,Mortimore B.J.,Odell C.N.,Pavitt R.,Pearce A.V.,Pearson D.,Phillimore B.J.C.T.,Phillips S.H.,Plumb R.W.,Ramsay H.,Ramsey Y.,Rogers L.,Ross M.T.,Scott C.E.,Sehra H.K.,Skuce C.D.,Smalley S.,Smith M.L.,Soderlund C.,Spragon L.,Steward C.A.,Sulston J.E.,Swann R.M.,Vaudin M.,Wall M.,Wallis J.M.,Whiteley M.N.,Willey D.L.,Williams L.,Williams S.A.,Williamson H.,Wilmer T.E.,Wilming L.,Wright C.L.,Hubbard T.,Bentley D.R.,Beck S.,Rogers J.,Shimizu N.,Minoshima S.,Kawasaki K.,Sasaki T.,Asakawa S.,Kudoh J.,Shintani A.,Shibuya K.,Yoshizaki Y.,Aoki N.,Mitsuyama S.,Roe B.A.,Chen F.,Chu L.,Crabtree J.,Deschamps S.,Do A.,Do T.,Dorman A.,Fang F.,Fu Y.,Hu P.,Hua A.,Kenton S.,Lai H.,Lao H.I.,Lewis J.,Lewis S.,Lin S.-P.,Loh P.,Malaj E.,Nguyen T.,Pan H.,Phan S.,Qi S.,Qian Y.,Ray L.,Ren Q.,Shaull S.,Sloan D.,Song L.,Wang Q.,Wang Y.,Wang Z.,White J.,Willingham D.,Wu H.,Yao Z.,Zhan M.,Zhang G.,Chissoe S.,Murray J.,Miller N.,Minx P.,Fulton R.,Johnson D.,Bemis G.,Bentley D.,Bradshaw H.,Bourne S.,Cordes M.,Du Z.,Fulton L.,Goela D.,Graves T.,Hawkins J.,Hinds K.,Kemp K.,Latreille P.,Layman D.,Ozersky P.,Rohlfing T.,Scheet P.,Walker C.,Wamsley A.,Wohldmann P.,Pepin K.,Nelson J.,Korf I.,Bedell J.A.,Hillier L.W.,Mardis E.,Waterston R.,Wilson R.,Emanuel B.S.,Shaikh T.,Kurahashi H.,Saitta S.,Budarf M.L.,McDermid H.E.,Johnson A.,Wong A.C.C.,Morrow B.E.,Edelmann L.,Kim U.J.,Shizuya H.,Simon M.I.,Dumanski J.P.,Peyrard M.,Kedra D.,Seroussi E.,Fransson I.,Tapia I.,Bruder C.E.,O'Brien K.P.,Wilkinson P.,Bodenteich A.,Hartman K.,Hu X.,Khan A.S.,Lane L.,Tilahun Y.,Wright H.
The DNA sequence of human chromosome 22.
Nature
402
489-495
1999
201054
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
201055
Murakami M.,Masuda S.,Shimbara S.,Bezzine S.,Lazdunski M.,Lambeau G.,Gelb M.H.,Matsukura S.,Kokubu F.,Adachi M.,Kudo I.
Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII).
J. Biol. Chem.
278
10657-10667
2003
201056
Murakami M.,Masuda S.,Shimbara S.,Ishikawa Y.,Ishii T.,Kudo I.
Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A(2).
J. Biol. Chem.
280
24987-24998
2005
201057
Masuda S.,Yamamoto K.,Hirabayashi T.,Ishikawa Y.,Ishii T.,Kudo I.,Murakami M.
Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival.
Biochem. J.
409
429-438
2008
201058
Sato H.,Kato R.,Isogai Y.,Saka G.,Ohtsuki M.,Taketomi Y.,Yamamoto K.,Tsutsumi K.,Yamada J.,Masuda S.,Ishikawa Y.,Ishii T.,Kobayashi T.,Ikeda K.,Taguchi R.,Hatakeyama S.,Hara S.,Kudo I.,Itabe H.,Murakami M.
Analyses of group III secreted phospholipase A2 transgenic mice reveal potential participation of this enzyme in plasma lipoprotein modification, macrophage foam cell formation, and atherosclerosis.
J. Biol. Chem.
283
33483-33497
2008
201059
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
201060
Kim J.,Lee J.E.,Heynen-Genel S.,Suyama E.,Ono K.,Lee K.,Ideker T.,Aza-Blanc P.,Gleeson J.G.
Functional genomic screen for modulators of ciliogenesis and cilium length.
Nature
464
1048-1051
2010
201061
Taketomi Y.,Ueno N.,Kojima T.,Sato H.,Murase R.,Yamamoto K.,Tanaka S.,Sakanaka M.,Nakamura M.,Nishito Y.,Kawana M.,Kambe N.,Ikeda K.,Taguchi R.,Nakamizo S.,Kabashima K.,Gelb M.H.,Arita M.,Yokomizo T.,Nakamura M.,Watanabe K.,Hirai H.,Nakamura M.,Okayama Y.,Ra C.,Aritake K.,Urade Y.,Morimoto K.,Sugimoto Y.,Shimizu T.,Narumiya S.,Hara S.,Murakami M.
Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Nat. Immunol.
14
554-563
2013
201062
Murase R.,Taketomi Y.,Miki Y.,Nishito Y.,Saito M.,Fukami K.,Yamamoto K.,Murakami M.
Group III phospholipase A2 promotes colitis and colorectal cancer.
Sci. Rep.
7
12261-12261
2017
