Sequence of NTRK2_MOUSE
EC Number:2.7.10.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.1
General information:
Sequence
0 MSPWLKWHGP AMARLWGLCL LVLGFWRASL ACPTSCKCSS ARIWCTEPSP GIVAFPRLEP
60 NSVDPENITE ILIANQKRLE IINEDDVEAY VGLRNLTIVD SGLKFVAYKA FLKNSNLRHI
120 NFTRNKLTSL SRRHFRHLDL SDLILTGNPF TCSCDIMWLK TLQETKSSPD TQDLYCLNES
180 SKNMPLANLQ IPNCGLPSAR LAAPNLTVEE GKSVTLSCSV GGDPLPTLYW DVGNLVSKHM
240 NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH
300 WCIPFTVRGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT
360 LMAKNEYGKD ERQISAHFMG RPGVDYETNP NYPEVLYEDW TTPTDIGDTT NKSNEIPSTD
420 VADQSNREHL SVYAVVVIAS VVGFCLLVML LLLKLARHSK FGMKGPASVI SNDDDSASPL
480 HHISNGSNTP SSSEGGPDAV IIGMTKIPVI ENPQYFGITN SQLKPDTFVQ HIKRHNIVLK
540 RELGEGAFGK VFLAECYNLC PEQDKILVAV KTLKDASDNA RKDFHREAEL LTNLQHEHIV
600 KFYGVCVEGD PLIMVFEYMK HGDLNKFLRA HGPDAVLMAE GNPPTELTQS QMLHIAQQIA
660 AGMVYLASQH FVHRDLATRN CLVGENLLVK IGDFGMSRDV YSTDYYRVGG HTMLPIRWMP
720 PESIMYRKFT TESDVWSLGV VLWEIFTYGK QPWYQLSNNE VIECITQGRV LQRPRTCPQE
780 VYELMLGCWQ REPHTRKNIK SIHTLLQNLA KASPVYLDIL G
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
197463
Klein R.,Parada L.F.,Coulier F.,Barbacid M.
trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.
EMBO J.
8
3701-3709
1989
197464
Klein R.,Conway D.,Parada L.F.,Barbacid M.
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain.
Cell
61
647-656
1990
197465
Carninci P.,Kasukawa T.,Katayama S.,Gough J.,Frith M.C.,Maeda N.,Oyama R.,Ravasi T.,Lenhard B.,Wells C.,Kodzius R.,Shimokawa K.,Bajic V.B.,Brenner S.E.,Batalov S.,Forrest A.R.,Zavolan M.,Davis M.J.,Wilming L.G.,Aidinis V.,Allen J.E.,Ambesi-Impiombato A.,Apweiler R.,Aturaliya R.N.,Bailey T.L.,Bansal M.,Baxter L.,Beisel K.W.,Bersano T.,Bono H.,Chalk A.M.,Chiu K.P.,Choudhary V.,Christoffels A.,Clutterbuck D.R.,Crowe M.L.,Dalla E.,Dalrymple B.P.,de Bono B.,Della Gatta G.,di Bernardo D.,Down T.,Engstrom P.,Fagiolini M.,Faulkner G.,Fletcher C.F.,Fukushima T.,Furuno M.,Futaki S.,Gariboldi M.,Georgii-Hemming P.,Gingeras T.R.,Gojobori T.,Green R.E.,Gustincich S.,Harbers M.,Hayashi Y.,Hensch T.K.,Hirokawa N.,Hill D.,Huminiecki L.,Iacono M.,Ikeo K.,Iwama A.,Ishikawa T.,Jakt M.,Kanapin A.,Katoh M.,Kawasawa Y.,Kelso J.,Kitamura H.,Kitano H.,Kollias G.,Krishnan S.P.,Kruger A.,Kummerfeld S.K.,Kurochkin I.V.,Lareau L.F.,Lazarevic D.,Lipovich L.,Liu J.,Liuni S.,McWilliam S.,Madan Babu M.,Madera M.,Marchionni L.,Matsuda H.,Matsuzawa S.,Miki H.,Mignone F.,Miyake S.,Morris K.,Mottagui-Tabar S.,Mulder N.,Nakano N.,Nakauchi H.,Ng P.,Nilsson R.,Nishiguchi S.,Nishikawa S.,Nori F.,Ohara O.,Okazaki Y.,Orlando V.,Pang K.C.,Pavan W.J.,Pavesi G.,Pesole G.,Petrovsky N.,Piazza S.,Reed J.,Reid J.F.,Ring B.Z.,Ringwald M.,Rost B.,Ruan Y.,Salzberg S.L.,Sandelin A.,Schneider C.,Schoenbach C.,Sekiguchi K.,Semple C.A.,Seno S.,Sessa L.,Sheng Y.,Shibata Y.,Shimada H.,Shimada K.,Silva D.,Sinclair B.,Sperling S.,Stupka E.,Sugiura K.,Sultana R.,Takenaka Y.,Taki K.,Tammoja K.,Tan S.L.,Tang S.,Taylor M.S.,Tegner J.,Teichmann S.A.,Ueda H.R.,van Nimwegen E.,Verardo R.,Wei C.L.,Yagi K.,Yamanishi H.,Zabarovsky E.,Zhu S.,Zimmer A.,Hide W.,Bult C.,Grimmond S.M.,Teasdale R.D.,Liu E.T.,Brusic V.,Quackenbush J.,Wahlestedt C.,Mattick J.S.,Hume D.A.,Kai C.,Sasaki D.,Tomaru Y.,Fukuda S.,Kanamori-Katayama M.,Suzuki M.,Aoki J.,Arakawa T.,Iida J.,Imamura K.,Itoh M.,Kato T.,Kawaji H.,Kawagashira N.,Kawashima T.,Kojima M.,Kondo S.,Konno H.,Nakano K.,Ninomiya N.,Nishio T.,Okada M.,Plessy C.,Shibata K.,Shiraki T.,Suzuki S.,Tagami M.,Waki K.,Watahiki A.,Okamura-Oho Y.,Suzuki H.,Kawai J.,Hayashizaki Y.
The transcriptional landscape of the mammalian genome.
Science
309
1559-1563
2005
197466
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
197467
Ninkina N.,Grashchuck M.,Buchman V.L.,Davies A.M.
TrkB variants with deletions in the leucine-rich motifs of the extracellular domain.
J. Biol. Chem.
272
13019-13025
1997
197468
Soppet D.,Escandon E.,Maragos J.,Middlemas D.S.,Reid S.W.,Blair J.,Burton L.E.,Stanton B.R.,Kaplan D.R.,Hunter T.,Nicolics K.,Parada L.F.
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor.
Cell
65
895-903
1991
197469
Klein R.,Smeyne R.J.,Wurst W.,Long L.K.,Auerbach B.A.,Joyner A.L.,Barbacid M.
Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death.
Cell
75
113-122
1993
197470
Farinas I.,Wilkinson G.A.,Backus C.,Reichardt L.F.,Patapoutian A.
Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo.
Neuron
21
325-334
1998
197471
Minichiello L.,Korte M.,Wolfer D.,Kuehn R.,Unsicker K.,Cestari V.,Rossi-Arnaud C.,Lipp H.P.,Bonhoeffer T.,Klein R.
Essential role for TrkB receptors in hippocampus-mediated learning.
Neuron
24
401-414
1999
197472
Minichiello L.,Calella A.M.,Medina D.L.,Bonhoeffer T.,Klein R.,Korte M.
Mechanism of TrkB-mediated hippocampal long-term potentiation.
Neuron
36
121-137
2002
197473
Du J.,Feng L.,Zaitsev E.,Je H.S.,Liu X.W.,Lu B.
Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx.
J. Cell Biol.
163
385-395
2003
197474
Rose C.R.,Blum R.,Pichler B.,Lepier A.,Kafitz K.W.,Konnerth A.
Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells.
Nature
426
74-78
2003
197475
Medina D.L.,Sciarretta C.,Calella A.M.,Von Bohlen Und Halbach O.,Unsicker K.,Minichiello L.
TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migration.
EMBO J.
23
3803-3814
2004
197476
Douma S.,Van Laar T.,Zevenhoven J.,Meuwissen R.,Van Garderen E.,Peeper D.S.
Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB.
Nature
430
1034-1039
2004
197477
Makkerh J.P.,Ceni C.,Auld D.S.,Vaillancourt F.,Dorval G.,Barker P.A.
p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation.
EMBO Rep.
6
936-941
2005
197478
Lo K.Y.,Chin W.H.,Ng Y.P.,Cheng A.W.,Cheung Z.H.,Ip N.Y.
SLAM-associated protein as a potential negative regulator in Trk signaling.
J. Biol. Chem.
280
41744-41752
2005
197479
Miyamoto Y.,Yamauchi J.,Tanoue A.,Wu C.,Mobley W.C.
TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology.
Proc. Natl. Acad. Sci. U.S.A.
103
10444-10449
2006
197480
Ballif B.A.,Carey G.R.,Sunyaev S.R.,Gygi S.P.
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
J. Proteome Res.
7
311-318
2008
197481
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
197482
Fu X.,Yang Y.,Xu C.,Niu Y.,Chen T.,Zhou Q.,Liu J.J.
Retrolinkin cooperates with endophilin A1 to mediate BDNF-TrkB early endocytic trafficking and signaling from early endosomes.
Mol. Biol. Cell
22
3684-3698
2011
197483
Chen A.I.,Nguyen C.N.,Copenhagen D.R.,Badurek S.,Minichiello L.,Ranscht B.,Reichardt L.F.
TrkB (tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex.
J. Neurosci.
31
2769-2780
2011
197484
Baeza-Raja B.,Eckel-Mahan K.,Zhang L.,Vagena E.,Tsigelny I.F.,Sassone-Corsi P.,Ptacek L.J.,Akassoglou K.
p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.
J. Neurosci.
33
10221-10234
2013
197485
Rohe M.,Hartl D.,Fjorback A.N.,Klose J.,Willnow T.E.
SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF.
PLoS ONE
8
0-0
2013
197486
Glerup S.,Bolcho U.,Moelgaard S.,Boeggild S.,Vaegter C.B.,Smith A.H.,Nieto-Gonzalez J.L.,Ovesen P.L.,Pedersen L.F.,Fjorback A.N.,Kjolby M.,Login H.,Holm M.M.,Andersen O.M.,Nyengaard J.R.,Willnow T.E.,Jensen K.,Nykjaer A.
SorCS2 is required for BDNF-dependent plasticity in the hippocampus.
Mol. Psychiatry
21
1740-1751
2016
