Sequence of NTRK2_HUMAN
EC Number:2.7.10.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Other sequences found for EC No. 2.7.10.1
General information:
Sequence
0 MSSWIRWHGP AMARLWGFCW LVVGFWRAAF ACPTSCKCSA SRIWCSDPSP GIVAFPRLEP
60 NSVDPENITE IFIANQKRLE IINEDDVEAY VGLRNLTIVD SGLKFVAHKA FLKNSNLQHI
120 NFTRNKLTSL SRKHFRHLDL SELILVGNPF TCSCDIMWIK TLQEAKSSPD TQDLYCLNES
180 SKNIPLANLQ IPNCGLPSAN LAAPNLTVEE GKSITLSCSV AGDPVPNMYW DVGNLVSKHM
240 NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH
300 WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT
360 LIAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY GTAANDIGDT TNRSNEIPST
420 DVTDKTGREH LSVYAVVVIA SVVGFCLLVM LFLLKLARHS KFGMKGPASV ISNDDDSASP
480 LHHISNGSNT PSSSEGGPDA VIIGMTKIPV IENPQYFGIT NSQLKPDTFV QHIKRHNIVL
540 KRELGEGAFG KVFLAECYNL CPEQDKILVA VKTLKDASDN ARKDFHREAE LLTNLQHEHI
600 VKFYGVCVEG DPLIMVFEYM KHGDLNKFLR AHGPDAVLMA EGNPPTELTQ SQMLHIAQQI
660 AAGMVYLASQ HFVHRDLATR NCLVGENLLV KIGDFGMSRD VYSTDYYRVG GHTMLPIRWM
720 PPESIMYRKF TTESDVWSLG VVLWEIFTYG KQPWYQLSNN EVIECITQGR VLQRPRTCPQ
780 EVYELMLGCW QREPHMRKNI KGIHTLLQNL AKASPVYLDI LG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
197442
Nakagawara A.,Liu X.-G.,Ikegaki N.,White P.S.,Yamashiro D.J.,Nycum L.M.,Biegel J.A.,Brodeur G.M.
Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2).
Genomics
25
538-546
1995
197443
Shelton D.L.,Sutherland J.,Gripp J.,Camerato T.,Armanini M.P.,Phillips H.S.,Carroll K.,Spencer S.D.,Levinson A.D.
Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins.
J. Neurosci.
15
477-491
1995
197444
Allen S.J.,Dawbarn D.,Eckford S.D.,Wilcock G.K.,Ashcroft M.,Colebrook S.M.,Feeney R.,Macgowan S.H.
Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain.
Neuroscience
60
825-834
1994
197445
Stoilov P.,Castren E.,Stamm S.
Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism.
Biochem. Biophys. Res. Commun.
290
1054-1065
2002
197447
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
197449
Humphray S.J.,Oliver K.,Hunt A.R.,Plumb R.W.,Loveland J.E.,Howe K.L.,Andrews T.D.,Searle S.,Hunt S.E.,Scott C.E.,Jones M.C.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Ashwell R.I.S.,Babbage A.K.,Babbage S.,Bagguley C.L.,Bailey J.,Banerjee R.,Barker D.J.,Barlow K.F.,Bates K.,Beasley H.,Beasley O.,Bird C.P.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.,Burrill W.,Burton J.,Carder C.,Carter N.P.,Chapman J.C.,Chen Y.,Clarke G.,Clark S.Y.,Clee C.M.,Clegg S.,Collier R.E.,Corby N.,Crosier M.,Cummings A.T.,Davies J.,Dhami P.,Dunn M.,Dutta I.,Dyer L.W.,Earthrowl M.E.,Faulkner L.,Fleming C.J.,Frankish A.,Frankland J.A.,French L.,Fricker D.G.,Garner P.,Garnett J.,Ghori J.,Gilbert J.G.R.,Glison C.,Grafham D.V.,Gribble S.,Griffiths C.,Griffiths-Jones S.,Grocock R.,Guy J.,Hall R.E.,Hammond S.,Harley J.L.,Harrison E.S.I.,Hart E.A.,Heath P.D.,Henderson C.D.,Hopkins B.L.,Howard P.J.,Howden P.J.,Huckle E.,Johnson C.,Johnson D.,Joy A.A.,Kay M.,Keenan S.,Kershaw J.K.,Kimberley A.M.,King A.,Knights A.,Laird G.K.,Langford C.,Lawlor S.,Leongamornlert D.A.,Leversha M.,Lloyd C.,Lloyd D.M.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,Matthews L.,McLaren S.,McLay K.E.,McMurray A.,Milne S.,Nickerson T.,Nisbett J.,Nordsiek G.,Pearce A.V.,Peck A.I.,Porter K.M.,Pandian R.,Pelan S.,Phillimore B.,Povey S.,Ramsey Y.,Rand V.,Scharfe M.,Sehra H.K.,Shownkeen R.,Sims S.K.,Skuce C.D.,Smith M.,Steward C.A.,Swarbreck D.,Sycamore N.,Tester J.,Thorpe A.,Tracey A.,Tromans A.,Thomas D.W.,Wall M.,Wallis J.M.,West A.P.,Whitehead S.L.,Willey D.L.,Williams S.A.,Wilming L.,Wray P.W.,Young L.,Ashurst J.L.,Coulson A.,Blocker H.,Durbin R.M.,Sulston J.E.,Hubbard T.,Jackson M.J.,Bentley D.R.,Beck S.,Rogers J.,Dunham I.
DNA sequence and analysis of human chromosome 9.
Nature
429
369-374
2004
197451
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
197452
Haniu M.,Talvenheimo J.,Le J.,Katta V.,Welcher A.,Rohde M.F.
Extracellular domain of neurotrophin receptor trkB: disulfide structure, N-glycosylation sites, and ligand binding.
Arch. Biochem. Biophys.
322
256-264
1995
197453
Meakin S.O.,MacDonald J.I.S.,Gryz E.A.,Kubu C.J.,Verdi J.M.
The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation.
J. Biol. Chem.
274
9861-9870
1999
197454
Liu T.,Qian W.-J.,Gritsenko M.A.,Camp D.G. II,Monroe M.E.,Moore R.J.,Smith R.D.
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
J. Proteome Res.
4
2070-2080
2005
197455
Luberg K.,Wong J.,Weickert C.S.,Timmusk T.
Human TrkB gene: novel alternative transcripts, protein isoforms and expression pattern in the prefrontal cerebral cortex during postnatal development.
J. Neurochem.
113
952-964
2010
197456
Ultsch M.H.,Wiesmann C.,Simmons L.C.,Henrich J.,Yang M.,Reilly D.,Bass S.H.,de Vos A.M.
Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
J. Mol. Biol.
290
149-159
1999
197457
Banfield M.J.,Naylor R.L.,Robertson A.G.,Allen S.J.,Dawbarn D.,Brady R.L.
Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5.
Structure
9
1191-1199
2001
197458
Yeo G.S.,Connie Hung C.C.,Rochford J.,Keogh J.,Gray J.,Sivaramakrishnan S.,O'Rahilly S.,Farooqi I.S.
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay.
Nat. Neurosci.
7
1187-1189
2004
197459
Greenman C.,Stephens P.,Smith R.,Dalgliesh G.L.,Hunter C.,Bignell G.,Davies H.,Teague J.,Butler A.,Stevens C.,Edkins S.,O'Meara S.,Vastrik I.,Schmidt E.E.,Avis T.,Barthorpe S.,Bhamra G.,Buck G.,Choudhury B.,Clements J.,Cole J.,Dicks E.,Forbes S.,Gray K.,Halliday K.,Harrison R.,Hills K.,Hinton J.,Jenkinson A.,Jones D.,Menzies A.,Mironenko T.,Perry J.,Raine K.,Richardson D.,Shepherd R.,Small A.,Tofts C.,Varian J.,Webb T.,West S.,Widaa S.,Yates A.,Cahill D.P.,Louis D.N.,Goldstraw P.,Nicholson A.G.,Brasseur F.,Looijenga L.,Weber B.L.,Chiew Y.-E.,DeFazio A.,Greaves M.F.,Green A.R.,Campbell P.,Birney E.,Easton D.F.,Chenevix-Trench G.,Tan M.-H.,Khoo S.K.,Teh B.T.,Yuen S.T.,Leung S.Y.,Wooster R.,Futreal P.A.,Stratton M.R.
Patterns of somatic mutation in human cancer genomes.
Nature
446
153-158
2007
197460
Marchetti A.,Felicioni L.,Pelosi G.,Del Grammastro M.,Fumagalli C.,Sciarrotta M.,Malatesta S.,Chella A.,Barassi F.,Mucilli F.,Camplese P.,D'Antuono T.,Sacco R.,Buttitta F.
Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung.
Hum. Mutat.
29
609-616
2008
197461
Miller K.A.,Twigg S.R.,McGowan S.J.,Phipps J.M.,Fenwick A.L.,Johnson D.,Wall S.A.,Noons P.,Rees K.E.,Tidey E.A.,Craft J.,Taylor J.,Taylor J.C.,Goos J.A.,Swagemakers S.M.,Mathijssen I.M.,van der Spek P.J.,Lord H.,Lester T.,Abid N.,Cilliers D.,Hurst J.A.,Morton J.E.,Sweeney E.,Weber A.,Wilson L.C.,Wilkie A.O.
Diagnostic value of exome and whole genome sequencing in craniosynostosis.
J. Med. Genet.
54
260-268
2017
197462
Hamdan F.F.,Myers C.T.,Cossette P.,Lemay P.,Spiegelman D.,Laporte A.D.,Nassif C.,Diallo O.,Monlong J.,Cadieux-Dion M.,Dobrzeniecka S.,Meloche C.,Retterer K.,Cho M.T.,Rosenfeld J.A.,Bi W.,Massicotte C.,Miguet M.,Brunga L.,Regan B.M.,Mo K.,Tam C.,Schneider A.,Hollingsworth G.,FitzPatrick D.R.,Donaldson A.,Canham N.,Blair E.,Kerr B.,Fry A.E.,Thomas R.H.,Shelagh J.,Hurst J.A.,Brittain H.,Blyth M.,Lebel R.R.,Gerkes E.H.,Davis-Keppen L.,Stein Q.,Chung W.K.,Dorison S.J.,Benke P.J.,Fassi E.,Corsten-Janssen N.,Kamsteeg E.J.,Mau-Them F.T.,Bruel A.L.,Verloes A.,Ounap K.,Wojcik M.H.,Albert D.V.F.,Venkateswaran S.,Ware T.,Jones D.,Liu Y.C.,Mohammad S.S.,Bizargity P.,Bacino C.A.,Leuzzi V.,Martinelli S.,Dallapiccola B.,Tartaglia M.,Blumkin L.,Wierenga K.J.,Purcarin G.,O'Byrne J.J.,Stockler S.,Lehman A.,Keren B.,Nougues M.C.,Mignot C.,Auvin S.,Nava C.,Hiatt S.M.,Bebin M.,Shao Y.,Scaglia F.,Lalani S.R.,Frye R.E.,Jarjour I.T.,Jacques S.,Boucher R.M.,Riou E.,Srour M.,Carmant L.,Lortie A.,Major P.,Diadori P.,Dubeau F.,D'Anjou G.,Bourque G.,Berkovic S.F.,Sadleir L.G.,Campeau P.M.,Kibar Z.,Lafreniere R.G.,Girard S.L.,Mercimek-Mahmutoglu S.,Boelman C.,Rouleau G.A.,Scheffer I.E.,Mefford H.C.,Andrade D.M.,Rossignol E.,Minassian B.A.,Michaud J.L.
High rate of recurrent de novo mutations in developmental and epileptic encephalopathies.
Am. J. Hum. Genet.
101
664-685
2017
