Sequence of LOX5_MOUSE

arachidonate 5-lipoxygenase

P48999

674

77967

183779

Chen X.-S.,Naumann T.A.,Kurre U.,Jenkins N.A.,Copeland N.G.,Funk C.D.

cDNA cloning, expression, mutagenesis, intracellular localization, and gene chromosomal assignment of mouse 5-lipoxygenase.

J. Biol. Chem.

270

17993-17999

1995

183780

Carninci P.,Kasukawa T.,Katayama S.,Gough J.,Frith M.C.,Maeda N.,Oyama R.,Ravasi T.,Lenhard B.,Wells C.,Kodzius R.,Shimokawa K.,Bajic V.B.,Brenner S.E.,Batalov S.,Forrest A.R.,Zavolan M.,Davis M.J.,Wilming L.G.,Aidinis V.,Allen J.E.,Ambesi-Impiombato A.,Apweiler R.,Aturaliya R.N.,Bailey T.L.,Bansal M.,Baxter L.,Beisel K.W.,Bersano T.,Bono H.,Chalk A.M.,Chiu K.P.,Choudhary V.,Christoffels A.,Clutterbuck D.R.,Crowe M.L.,Dalla E.,Dalrymple B.P.,de Bono B.,Della Gatta G.,di Bernardo D.,Down T.,Engstrom P.,Fagiolini M.,Faulkner G.,Fletcher C.F.,Fukushima T.,Furuno M.,Futaki S.,Gariboldi M.,Georgii-Hemming P.,Gingeras T.R.,Gojobori T.,Green R.E.,Gustincich S.,Harbers M.,Hayashi Y.,Hensch T.K.,Hirokawa N.,Hill D.,Huminiecki L.,Iacono M.,Ikeo K.,Iwama A.,Ishikawa T.,Jakt M.,Kanapin A.,Katoh M.,Kawasawa Y.,Kelso J.,Kitamura H.,Kitano H.,Kollias G.,Krishnan S.P.,Kruger A.,Kummerfeld S.K.,Kurochkin I.V.,Lareau L.F.,Lazarevic D.,Lipovich L.,Liu J.,Liuni S.,McWilliam S.,Madan Babu M.,Madera M.,Marchionni L.,Matsuda H.,Matsuzawa S.,Miki H.,Mignone F.,Miyake S.,Morris K.,Mottagui-Tabar S.,Mulder N.,Nakano N.,Nakauchi H.,Ng P.,Nilsson R.,Nishiguchi S.,Nishikawa S.,Nori F.,Ohara O.,Okazaki Y.,Orlando V.,Pang K.C.,Pavan W.J.,Pavesi G.,Pesole G.,Petrovsky N.,Piazza S.,Reed J.,Reid J.F.,Ring B.Z.,Ringwald M.,Rost B.,Ruan Y.,Salzberg S.L.,Sandelin A.,Schneider C.,Schoenbach C.,Sekiguchi K.,Semple C.A.,Seno S.,Sessa L.,Sheng Y.,Shibata Y.,Shimada H.,Shimada K.,Silva D.,Sinclair B.,Sperling S.,Stupka E.,Sugiura K.,Sultana R.,Takenaka Y.,Taki K.,Tammoja K.,Tan S.L.,Tang S.,Taylor M.S.,Tegner J.,Teichmann S.A.,Ueda H.R.,van Nimwegen E.,Verardo R.,Wei C.L.,Yagi K.,Yamanishi H.,Zabarovsky E.,Zhu S.,Zimmer A.,Hide W.,Bult C.,Grimmond S.M.,Teasdale R.D.,Liu E.T.,Brusic V.,Quackenbush J.,Wahlestedt C.,Mattick J.S.,Hume D.A.,Kai C.,Sasaki D.,Tomaru Y.,Fukuda S.,Kanamori-Katayama M.,Suzuki M.,Aoki J.,Arakawa T.,Iida J.,Imamura K.,Itoh M.,Kato T.,Kawaji H.,Kawagashira N.,Kawashima T.,Kojima M.,Kondo S.,Konno H.,Nakano K.,Ninomiya N.,Nishio T.,Okada M.,Plessy C.,Shibata K.,Shiraki T.,Suzuki S.,Tagami M.,Waki K.,Watahiki A.,Okamura-Oho Y.,Suzuki H.,Kawai J.,Hayashizaki Y.

The transcriptional landscape of the mammalian genome.

Science

309

1559-1563

2005

183781

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

183782

Goulet J.L.,Snouwaert J.N.,Latour A.M.,Coffman T.M.,Koller B.H.

Altered inflammatory responses in leukotriene-deficient mice.

Proc. Natl. Acad. Sci. U.S.A.

91

12852-12856

1994

183783

Chen X.S.,Sheller J.R.,Johnson E.N.,Funk C.D.

Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene.

Nature

372

179-182

1994

183784

Doepping S.,Funk C.D.,Habenicht A.J.,Spanbroek R.

Selective 5-lipoxygenase expression in Langerhans cells and impaired dendritic cell migration in 5-LO-deficient mice reveal leukotriene action in skin.

J. Invest. Dermatol.

127

1692-1700

2007

183785

Mehrabian M.,Schulthess F.T.,Nebohacova M.,Castellani L.W.,Zhou Z.,Hartiala J.,Oberholzer J.,Lusis A.J.,Maedler K.,Allayee H.

Identification of ALOX5 as a gene regulating adiposity and pancreatic function.

Diabetologia

51

978-988

2008

183786

Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.

A tissue-specific atlas of mouse protein phosphorylation and expression.

Cell

143

1174-1189

2010

183787

Nagashima T.,Ichimiya S.,Kikuchi T.,Saito Y.,Matsumiya H.,Ara S.,Koshiba S.,Zhang J.,Hatate C.,Tonooka A.,Kubo T.,Ye R.C.,Hirose B.,Shirasaki H.,Izumi T.,Takami T.,Himi T.,Sato N.

Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help.

Am. J. Pathol.

178

222-232

2011

183788

Sapieha P.,Stahl A.,Chen J.,Seaward M.R.,Willett K.L.,Krah N.M.,Dennison R.J.,Connor K.M.,Aderman C.M.,Liclican E.,Carughi A.,Perelman D.,Kanaoka Y.,Sangiovanni J.P.,Gronert K.,Smith L.E.

5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of omega-3 polyunsaturated fatty acids.

Sci. Transl. Med.

3

0-0

2011

183789

Hofheinz K.,Kakularam K.R.,Adel S.,Anton M.,Polymarasetty A.,Reddanna P.,Kuhn H.,Horn T.

Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants.

Arch. Biochem. Biophys.

530

40-47

2013

183790

Lee S.J.,Choi E.K.,Seo K.W.,Bae J.U.,Kim Y.H.,Park S.Y.,Oh S.O.,Kim C.D.

5-Lipoxygenase plays a pivotal role in endothelial adhesion of monocytes via an increased expression of Mac-1.

Cardiovasc. Res.

99

724-733

2013

183791

Wu Y.,Sun H.,Song F.,Huang C.,Wang J.

Deletion of Alox5 gene decreases osteogenic differentiation but increases adipogenic differentiation of mouse induced pluripotent stem cells.

Cell Tissue Res.

358

135-147

2014

183792

Brogliato A.R.,Moor A.N.,Kesl S.L.,Guilherme R.F.,Georgii J.L.,Peters-Golden M.,Canetti C.,Gould L.J.,Benjamim C.F.

Critical role of 5-lipoxygenase and heme oxygenase-1 in wound healing.

J. Invest. Dermatol.

134

1436-1445

2014

183793

Kwak H.J.,Choi H.E.,Cheon H.G.

5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes.

Sci. Rep.

7

5025-5025

2017

183794

Guimaraes F.R.,Sales-Campos H.,Nardini V.,da Costa T.A.,Fonseca M.T.C.,Junior V.R.,Sorgi C.A.,da Silva J.S.,Chica J.E.L.,Faccioli L.H.,de Barros Cardoso C.R.

The inhibition of 5-Lipoxygenase (5-LO) products leukotriene B4 (LTB4) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves cutaneous wound healing.

Clin. Immunol.

190

74-83

2018

183795

Marbach-Breitrueck E.,Kutzner L.,Rothe M.,Gurke R.,Schreiber Y.,Reddanna P.,Schebb N.H.,Stehling S.,Wieler L.H.,Heydeck D.,Kuhn H.

Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.

Antioxid. Redox Signal.

32

1-17

2020