Sequence of LOX5_HUMAN

arachidonate 5-lipoxygenase

P09917

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183743

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Molecular cloning and amino acid sequence of human 5-lipoxygenase.

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Funk C.D.,Hoshiko S.,Matsumoto T.,Raadmark O.,Samuelsson B.

Characterization of the human 5-lipoxygenase gene.

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183751

Hoshiko S.,Raadmark O.,Samuelsson B.

Characterization of the human 5-lipoxygenase gene promoter.

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183752

Rouzer C.A.,Samuelsson B.

Reversible, calcium-dependent membrane association of human leukocyte 5-lipoxygenase.

Proc. Natl. Acad. Sci. U.S.A.

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183753

Nguyen T.,Falgueyret J.-P.,Abramowitz M.,Riendeau D.

Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase.

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183754

Ishii S.,Noguchi M.,Miyano M.,Matsumoto T.,Noma M.

Mutagenesis studies on the amino acid residues involved in the iron-binding and the activity of human 5-lipoxygenase.

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183755

Woods J.W.,Evans J.F.,Ethier D.,Scott S.,Vickers P.J.,Hearn L.,Heibein J.A.,Charleson S.,Singer I.I.

5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.

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183756

Lepley R.A.,Fitzpatrick F.A.

5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins.

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183757

Petrich K.,Ludwig P.,Kuehn H.,Schewe T.

The suppression of 5-lipoxygenation of arachidonic acid in human polymorphonuclear leucocytes by the 15-lipoxygenase product (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid: structure-activity relationship and mechanism of action.

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De Carolis E.,Denis D.,Riendeau D.

Oxidative inactivation of human 5-lipoxygenase in phosphatidylcholine vesicles.

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Werz O.,Szellas D.,Steinhilber D.,Radmark O.

Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2).

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Luo M.,Jones S.M.,Phare S.M.,Coffey M.J.,Peters-Golden M.,Brock T.G.

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Tjonahen E.,Oh S.F.,Siegelman J.,Elangovan S.,Percarpio K.B.,Hong S.,Arita M.,Serhan C.N.

Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis.

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Flamand N.,Lefebvre J.,Surette M.E.,Picard S.,Borgeat P.

Arachidonic acid regulates the translocation of 5-lipoxygenase to the nuclear membranes in human neutrophils.

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Dincbas-Renqvist V.,Pepin G.,Rakonjac M.,Plante I.,Ouellet D.L.,Hermansson A.,Goulet I.,Doucet J.,Samuelsson B.,Raadmark O.,Provost P.

Human Dicer C-terminus functions as a 5-lipoxygenase binding domain.

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Strid T.,Svartz J.,Franck N.,Hallin E.,Ingelsson B.,Soederstroem M.,Hammarstroem S.

Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein.

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Flamand N.,Luo M.,Peters-Golden M.,Brock T.G.

Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.

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Esser J.,Rakonjac M.,Hofmann B.,Fischer L.,Provost P.,Schneider G.,Steinhilber D.,Samuelsson B.,Radmark O.

Coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase: role of tryptophan 102.

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Ha Y.J.,Seul H.J.,Lee J.R.

Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK.

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Oh S.F.,Pillai P.S.,Recchiuti A.,Yang R.,Serhan C.N.

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation.

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Hofheinz K.,Kakularam K.R.,Adel S.,Anton M.,Polymarasetty A.,Reddanna P.,Kuhn H.,Horn T.

Conversion of pro-inflammatory murine Alox5 into an anti-inflammatory 15S-lipoxygenating enzyme by multiple mutations of sequence determinants.

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Horn T.,Reddy Kakularam K.,Anton M.,Richter C.,Reddanna P.,Kuhn H.

Functional characterization of genetic enzyme variations in human lipoxygenases.

Redox Biol.

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Smyrniotis C.J.,Barbour S.R.,Xia Z.,Hixon M.S.,Holman T.R.

ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid.

Biochemistry

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4407-4419

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Mahshid Y.,Markoutsa S.,Dincbas-Renqvist V.,Sueruen D.,Christensson B.,Sander B.,Bjoerkholm M.,Sorg B.L.,Raadmark O.,Claesson H.E.

Phosphorylation of serine 523 on 5-lipoxygenase in human B lymphocytes.

Prostaglandins Leukot. Essent. Fatty Acids

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Ivanov I.,Golovanov A.B.,Ferretti C.,Canyelles-Nino M.,Heydeck D.,Stehling S.,Lluch J.M.,Gonzalez-Lafont A.,Kuehn H.

Mutations of Triad Determinants Changes the Substrate Alignment at the Catalytic Center of Human ALOX5.

ACS Chem. Biol.

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Gilbert N.C.,Bartlett S.G.,Waight M.T.,Neau D.B.,Boeglin W.E.,Brash A.R.,Newcomer M.E.

The structure of human 5-lipoxygenase.

Science

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Gilbert N.C.,Rui Z.,Neau D.B.,Waight M.T.,Bartlett S.G.,Boeglin W.E.,Brash A.R.,Newcomer M.E.

Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663.

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Perry S.C.,Kalyanaraman C.,Tourdot B.E.,Conrad W.S.,Akinkugbe O.,Freedman J.C.,Holinstat M.,Jacobson M.P.,Holman T.R.

15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.

J. Lipid Res.

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2020

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Goodman J.E.,Bowman E.D.,Chanock S.J.,Alberg A.J.,Harris C.C.

Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.

Carcinogenesis

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2004