Sequence of HMDH2_ASPFU
EC Number:1.1.1.34
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
hydroxymethylglutaryl-CoA reductase (NADPH)
Q4WSY2
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
1062
115278
Reaction
(R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+
Other sequences found for EC No. 1.1.1.34
General information:
Sequence
0 MAPTNTKDSD TPGWLHRHGT SVLGSVARQA CKQPIYTLVI TALLATMTYT SLLEGSLYNA
60 NLTRLSNSHL NQLDVTDFLQ GSRSLRLGKA TAWQWETDDE SMSDQEVRPS FFLDPVASHL
120 ALITLVFPTS ENNPGISAVQ ESIISDLAAA QLVSRTPSVL SSTFRETSIT LSVPYNNLEE
180 VLRKTQNFPQ PEAEHSWTLK NAGKCNSGPK LRLWLIDVLA SFVGLIKHAQ IIDIIIMLLA
240 YLAMHLTFLS LFMSMRQLGS RFWLAYSVLL SGFFSLFFGL KVTTSSGVST SMITLSECLP
300 ILVIIVGFEK PIRLTRAVLR AATESYLPAK PMARRSTPEA IEVAIMREGW RIVRDYAIEI
360 AILAAGATSR VQGALPQFCF LAAWILLFDS LLLFTFYISV LCVKLEITRI RKHVEPRRAL
420 EDDDISTGNQ DFDSRVFGCK VKAANISRFK FLMVGGFVLF NVLQLSSLTY GNVRVSDWMP
480 YLSNLSNTLM PAPINPYRVA RNGLDDIYVA SRANNIETRV TVLPPIKYVL QSQSRHCRDN
540 FAGPLCDTLR GRTLGCVLAW LEDPVISKWV IAALFLSLVL NSYLMKAARW NLRQSEVIPD
600 SSATVSQTKD SSNKLAEKRT VDAMLQEGRV SLLEDEEIVN LCLRGKISAH ALEKTMERHP
660 TMSRLEAFTR AVKIRRTVVS RTPSTIDVSS SLEYSKAPFE NYDYTLVHGA CCENIIGYLP
720 LPVGAAGPLV IDGRNYFIPM ATTEGVLVAS ASRGCKAINA GGGAVTVINA DGMTRGPCLA
780 FSSVSRAAEA KQWIDSDEGK KILATAFNST SRFARLQGLK SAQAGTYLYV RFKSTTGDAM
840 GMNMISKGVE KALEVMKGHG FSDMSTISVT GNYCVDKKPA AINWIDGRGK SVVAEALIPA
900 DAVRSVLKTD VDALVELNTA KNLVGSAMAG SIGGFNVHAS NLVAAVLLAT GQDPAQNVES
960 SSCITIMKNV NNNLHISVSM PCIEVGTIGG GTILEPQAAM LDLLGVRGAH ATNPGDNARQ
1020 LARIVAAAVL AGELSTCAAL AAGHLVSAHM AHNRSKVAAK TG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
172546
Nierman W.C.,Pain A.,Anderson M.J.,Wortman J.R.,Kim H.S.,Arroyo J.,Berriman M.,Abe K.,Archer D.B.,Bermejo C.,Bennett J.W.,Bowyer P.,Chen D.,Collins M.,Coulsen R.,Davies R.,Dyer P.S.,Farman M.L.,Fedorova N.,Fedorova N.D.,Feldblyum T.V.,Fischer R.,Fosker N.,Fraser A.,Garcia J.L.,Garcia M.J.,Goble A.,Goldman G.H.,Gomi K.,Griffith-Jones S.,Gwilliam R.,Haas B.J.,Haas H.,Harris D.E.,Horiuchi H.,Huang J.,Humphray S.,Jimenez J.,Keller N.,Khouri H.,Kitamoto K.,Kobayashi T.,Konzack S.,Kulkarni R.,Kumagai T.,Lafton A.,Latge J.-P.,Li W.,Lord A.,Lu C.,Majoros W.H.,May G.S.,Miller B.L.,Mohamoud Y.,Molina M.,Monod M.,Mouyna I.,Mulligan S.,Murphy L.D.,O'Neil S.,Paulsen I.,Penalva M.A.,Pertea M.,Price C.,Pritchard B.L.,Quail M.A.,Rabbinowitsch E.,Rawlins N.,Rajandream M.A.,Reichard U.,Renauld H.,Robson G.D.,Rodriguez de Cordoba S.,Rodriguez-Pena J.M.,Ronning C.M.,Rutter S.,Salzberg S.L.,Sanchez M.,Sanchez-Ferrero J.C.,Saunders D.,Seeger K.,Squares R.,Squares S.,Takeuchi M.,Tekaia F.,Turner G.,Vazquez de Aldana C.R.,Weidman J.,White O.,Woodward J.R.,Yu J.-H.,Fraser C.M.,Galagan J.E.,Asai K.,Machida M.,Hall N.,Barrell B.G.,Denning D.W.
Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.
Nature
438
1151-1156
2005
172547
Ferreira M.E.,Colombo A.L.,Paulsen I.,Ren Q.,Wortman J.,Huang J.,Goldman M.H.,Goldman G.H.
The ergosterol biosynthesis pathway, transporter genes, and azole resistance in Aspergillus fumigatus.
Med. Mycol.
43
0-0
2005
172548
Yasmin S.,Alcazar-Fuoli L.,Gruendlinger M.,Puempel T.,Cairns T.,Blatzer M.,Lopez J.F.,Grimalt J.O.,Bignell E.,Haas H.
Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus.
Proc. Natl. Acad. Sci. U.S.A.
109
0-0
2012
