Sequence of HIF1N_HUMAN

hypoxia-inducible factor-asparagine dioxygenase

Q9NWT6

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171817

Mahon P.C.,Hirota K.,Semenza G.L.

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity.

Genes Dev.

15

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2001

171818

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

171819

Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.

The DNA sequence and comparative analysis of human chromosome 10.

Nature

429

375-381

2004

171821

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

171822

Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.

The full-ORF clone resource of the German cDNA consortium.

BMC Genomics

8

399-399

2007

171823

Lando D.,Peet D.J.,Gorman J.J.,Whelan D.A.,Whitelaw M.L.,Bruick R.K.

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.

Genes Dev.

16

1466-1471

2002

171824

Hewitson K.S.,McNeill L.A.,Riordan M.V.,Tian Y.-M.,Bullock A.N.,Welford R.W.,Elkins J.M.,Oldham N.J.,Bhattacharya S.,Gleadle J.M.,Ratcliffe P.J.,Pugh C.W.,Schofield C.J.

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.

J. Biol. Chem.

277

26351-26355

2002

171825

Lancaster D.E.,McNeill L.A.,McDonough M.A.,Aplin R.T.,Hewitson K.S.,Pugh C.W.,Ratcliffe P.J.,Schofield C.J.

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.

Biochem. J.

383

429-437

2004

171826

Koivunen P.,Hirsila M.,Gunzler V.,Kivirikko K.I.,Myllyharju J.

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.

J. Biol. Chem.

279

9899-9904

2004

171827

Linke S.,Stojkoski C.,Kewley R.J.,Booker G.W.,Whitelaw M.L.,Peet D.J.

Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor.

J. Biol. Chem.

279

14391-14397

2004

171828

Cockman M.E.,Lancaster D.E.,Stolze I.P.,Hewitson K.S.,McDonough M.A.,Coleman M.L.,Coles C.H.,Yu X.,Hay R.T.,Ley S.C.,Pugh C.W.,Oldham N.J.,Masson N.,Schofield C.J.,Ratcliffe P.J.

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).

Proc. Natl. Acad. Sci. U.S.A.

103

14767-14772

2006

171829

Zheng X.,Linke S.,Dias J.M.,Zheng X.,Gradin K.,Wallis T.P.,Hamilton B.R.,Gustafsson M.,Ruas J.L.,Wilkins S.,Bilton R.L.,Brismar K.,Whitelaw M.L.,Pereira T.,Gorman J.J.,Ericson J.,Peet D.J.,Lendahl U.,Poellinger L.

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways.

Proc. Natl. Acad. Sci. U.S.A.

105

3368-3373

2008

171830

Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

Anal. Chem.

81

4493-4501

2009

171831

Webb J.D.,Muranyi A.,Pugh C.W.,Ratcliffe P.J.,Coleman M.L.

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).

Biochem. J.

420

327-333

2009

171832

Sakamoto T.,Seiki M.

Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1.

J. Biol. Chem.

284

30350-30359

2009

171833

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

171834

Martinez-Noel G.,Galligan J.T.,Sowa M.E.,Arndt V.,Overton T.M.,Harper J.W.,Howley P.M.

Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.

Mol. Cell. Biol.

32

3095-3106

2012

171835

Bienvenut W.V.,Sumpton D.,Martinez A.,Lilla S.,Espagne C.,Meinnel T.,Giglione C.

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

Mol. Cell. Proteomics

11

0-0

2012

171836

Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Proc. Natl. Acad. Sci. U.S.A.

109

12449-12454

2012

171837

Nakaoka H.J.,Hara T.,Yoshino S.,Kanamori A.,Matsui Y.,Shimamura T.,Sato H.,Murakami Y.,Seiki M.,Sakamoto T.

NECAB3 promotes activation of hypoxia-inducible factor-1 during normoxia and enhances tumourigenicity of cancer cells.

Sci. Rep.

6

22784-22784

2016

171838

Dann C.E. III,Bruick R.K.,Deisenhofer J.

Structure of factor-inhibiting hypoxia-inducible factor 1: an asparaginyl hydroxylase involved in the hypoxic response pathway.

Proc. Natl. Acad. Sci. U.S.A.

99

15351-15356

2002

171839

Elkins J.M.,Hewitson K.S.,McNeill L.A.,Seibel J.F.,Schlemminger I.,Pugh C.W.,Ratcliffe P.J.,Schofield C.J.

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.

J. Biol. Chem.

278

1802-1806

2003

171840

Lee C.,Kim S.J.,Jeong D.G.,Lee S.M.,Ryu S.E.

Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau.

J. Biol. Chem.

278

7558-7563

2003

171841

McDonough M.A.,McNeill L.A.,Tilliet M.,Papamicael C.A.,Chen Q.Y.,Banerji B.,Hewitson K.S.,Schofield C.J.

Selective inhibition of factor inhibiting hypoxia-inducible factor.

J. Am. Chem. Soc.

127

7680-7681

2005

171842

Hewitson K.S.,Lienard B.M.,McDonough M.A.,Clifton I.J.,Butler D.,Soares A.S.,Oldham N.J.,McNeill L.A.,Schofield C.J.

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates.

J. Biol. Chem.

282

3293-3301

2007

171843

Coleman M.L.,McDonough M.A.,Hewitson K.S.,Coles C.,Mecinovic J.,Edelmann M.,Cook K.M.,Cockman M.E.,Lancaster D.E.,Kessler B.M.,Oldham N.J.,Ratcliffe P.J.,Schofield C.J.

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.

J. Biol. Chem.

282

24027-24038

2007

171844

Hewitson K.S.,Holmes S.L.,Ehrismann D.,Hardy A.P.,Chowdhury R.,Schofield C.J.,McDonough M.A.

Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).

J. Biol. Chem.

283

25971-25978

2008

171845

Conejo-Garcia A.,McDonough M.A.,Loenarz C.,McNeill L.A.,Hewitson K.S.,Ge W.,Lienard B.M.,Schofield C.J.,Clifton I.J.

Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor.

Bioorg. Med. Chem. Lett.

20

6125-6128

2010

171846

Moon H.,Han S.,Park H.,Choe J.

Crystal structures of human FIH-1 in complex with quinol family inhibitors.

Mol. Cells

29

471-474

2010

171847

Chowdhury R.,Yeoh K.K.,Tian Y.M.,Hillringhaus L.,Bagg E.A.,Rose N.R.,Leung I.K.,Li X.S.,Woon E.C.,Yang M.,McDonough M.A.,King O.N.,Clifton I.J.,Klose R.J.,Claridge T.D.,Ratcliffe P.J.,Schofield C.J.,Kawamura A.

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.

EMBO Rep.

12

463-469

2011

171848

Yang M.,Chowdhury R.,Ge W.,Hamed R.B.,McDonough M.A.,Claridge T.D.,Kessler B.M.,Cockman M.E.,Ratcliffe P.J.,Schofield C.J.

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains.

FEBS J.

278

1086-1097

2011

171849

Yang M.,Ge W.,Chowdhury R.,Claridge T.D.,Kramer H.B.,Schmierer B.,McDonough M.A.,Gong L.,Kessler B.M.,Ratcliffe P.J.,Coleman M.L.,Schofield C.J.

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.

J. Biol. Chem.

286

7648-7660

2011