Sequence of HGPRT_MYCTU
EC Number:2.4.2.8
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
hypoxanthine phosphoribosyltransferase
P9WHQ9
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
202
22251
Reaction
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
Other sequences found for EC No. 2.4.2.8
General information:
Sequence
0 MHVTQSSSAI TPGQTAELYP GDIKSVLLTA EQIQARIAEL GEQIGNDYRE LSATTGQDLL
60 LITVLKGAVL FVTDLARAIP VPTQFEFMAV SSYGSSTSSS GVVRILKDLD RDIHGRDVLI
120 VEDVVDSGLT LSWLSRNLTS RNPRSLRVCT LLRKPDAVHA NVEIAYVGFD IPNDFVVGYG
180 LDYDERYRDL SYIGTLDPRV YQ
Download this sequence
in fasta formatDownload all sequences for 2.4.2.8
in fasta format
in csv (Excel, OpenOffice) formatSequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
171721
Cole S.T.,Brosch R.,Parkhill J.,Garnier T.,Churcher C.M.,Harris D.E.,Gordon S.V.,Eiglmeier K.,Gas S.,Barry C.E. III,Tekaia F.,Badcock K.,Basham D.,Brown D.,Chillingworth T.,Connor R.,Davies R.M.,Devlin K.,Feltwell T.,Gentles S.,Hamlin N.,Holroyd S.,Hornsby T.,Jagels K.,Krogh A.,McLean J.,Moule S.,Murphy L.D.,Oliver S.,Osborne J.,Quail M.A.,Rajandream M.A.,Rogers J.,Rutter S.,Seeger K.,Skelton S.,Squares S.,Squares R.,Sulston J.E.,Taylor K.,Whitehead S.,Barrell B.G.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature
393
537-544
1998
171722
Kelkar D.S.,Kumar D.,Kumar P.,Balakrishnan L.,Muthusamy B.,Yadav A.K.,Shrivastava P.,Marimuthu A.,Anand S.,Sundaram H.,Kingsbury R.,Harsha H.C.,Nair B.,Prasad T.S.,Chauhan D.S.,Katoch K.,Katoch V.M.,Kumar P.,Chaerkady R.,Ramachandran S.,Dash D.,Pandey A.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Mol. Cell. Proteomics
10
0-0
2011
171723
Parker W.B.,Long M.C.
Purine metabolism in Mycobacterium tuberculosis as a target for drug development.
Curr. Pharm. Des.
13
599-608
2007
171724
Biazus G.,Schneider C.Z.,Palma M.S.,Basso L.A.,Santos D.S.
Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning, expression, and biochemical characterization.
Protein Expr. Purif.
66
185-190
2009
171725
Ducati R.G.,Breda A.,Basso L.A.,Santos D.S.
Purine Salvage Pathway in Mycobacterium tuberculosis.
Curr. Med. Chem.
18
1258-1275
2011
171726
Eng W.S.,Keough D.T.,Hockova D.,Winzor D.J.,Guddat L.W.
Oligomeric state of hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochimie
135
6-14
2017
171727
Eng W.S.,Hockova D.,Spacek P.,Janeba Z.,West N.P.,Woods K.,Naesens L.M.,Keough D.T.,Guddat L.W.
First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
J. Med. Chem.
58
4822-4838
2015
171728
Eng W.S.,Rejman D.,Pohl R.,West N.P.,Woods K.,Naesens L.M.J.,Keough D.T.,Guddat L.W.
Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase.
Eur. J. Med. Chem.
159
10-22
2018
