Sequence of HPCH_ECOLX

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
4-hydroxy-2-oxoheptanedioate aldolase
Q47098
Escherichia coli
262
28073
Reaction
4-hydroxy-2-oxoheptanedioate = pyruvate + succinate semialdehyde
Sequences with same EC No.
Sequence
show sequence in fasta format
  0 MENSFKAALK AGRPQIGLWL GLSSSYSAEL LAGAGFDWLL IDGEHAPNNV QTVLTQLQAI
 60 APYPSQPVVR PSWNDPVQIK QLLDVGTQTL LVPMVQNADE AREAVRATRY PPAGIRGVGS
120 ALARASRWNR IPDYLQKAND QMCVLVQIET REAMKNLPQI LDVEGVDGVF IGPADLSADM
180 GYAGNPQHPE VQAAIEQAIV QIRESGKAPG ILIANEQLAK RYLELGALFV AVGVDTTLLA
240 RAAEALAARF GAQATAVKPG VY
Download this sequence
in fasta format
Download all sequences for 4.1.2.52
in fasta format
in csv (Excel, OpenOffice) format
Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
168674
Stringfellow J.M.,Turpin B.,Cooper R.A.
Sequence of the Escherichia coli C homoprotocatechuic acid degradative operon completed with that of the 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase-encoding gene (hpcH).
Gene
166
73-76
1995
168675
Prieto M.A.,Diaz E.,Garcia J.L.
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
J. Bacteriol.
178
111-120
1996
168676
Rea D.,Fueloep V.,Bugg T.D.H.,Roper D.I.
Expression, purification and preliminary crystallographic analysis of 2,4-dihydroxy-hepta-2-ene-1,7-dioate aldolase (HpcH) from Escherichia coli C.
Acta Crystallogr. F
61
821-824
2005
168677
Wang W.,Seah S.Y.K.
Purification and biochemical characterization of a pyruvate-specific class II aldolase, HpaI.
Biochemistry
44
9447-9455
2005
168678
Wang W.,Seah S.Y.K.
The role of a conserved histidine residue in a pyruvate-specific Class II aldolase.
FEBS Lett.
582
3385-3388
2008
168679
Wang W.,Baker P.,Seah S.Y.
Comparison of two metal-dependent pyruvate aldolases related by convergent evolution: substrate specificity, kinetic mechanism, and substrate channeling.
Biochemistry
49
3774-3782
2010
168680
Rea D.,Fueloep V.,Bugg T.D.H.,Roper D.I.
Structure and mechanism of HpcH: a metal ion dependent class II aldolase from the homoprotocatechuate degradation pathway of Escherichia coli.
J. Mol. Biol.
373
866-876
2007