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Sequence of SIR2A_PLAF7

EC Number:3.5.1.17

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
acyl-lysine deacylase
Q8IE47
Plasmodium falciparum (isolate 3D7)
273
30344
Reaction
N6-acyl-L-lysine + H2O = a carboxylate + L-lysine
Other sequences found for EC No. 3.5.1.17

General information:

Sequence
show sequence in fasta format
  0 MGNLMISFLK KDTQSITLEE LAKIIKKCKH VVALTGSGTS AESNIPSFRG SSNSIWSKYD
 60 PRIYGTIWGF WKYPEKIWEV IRDISSDYEI EINNGHVALS TLESLGYLKS VVTQNVDGLH
120 EASGNTKVIS LHGNVFEAVC CTCNKIVKLN KIMLQKTSHF MHQLPPECPC GGIFKPNIIL
180 FGEVVSSDLL KEAEEEIAKC DLLLVIGTSS TVSTATNLCH FACKKKKKIV EINISKTYIT
240 NKMSDYHVCA KFSELTKVAN ILKGSSEKNK KIM
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
611157
Gardner M.J.,Hall N.,Fung E.,White O.,Berriman M.,Hyman R.W.,Carlton J.M.,Pain A.,Nelson K.E.,Bowman S.,Paulsen I.T.,James K.D.,Eisen J.A.,Rutherford K.M.,Salzberg S.L.,Craig A.,Kyes S.,Chan M.-S.,Nene V.,Shallom S.J.,Suh B.,Peterson J.,Angiuoli S.,Pertea M.,Allen J.,Selengut J.,Haft D.,Mather M.W.,Vaidya A.B.,Martin D.M.A.,Fairlamb A.H.,Fraunholz M.J.,Roos D.S.,Ralph S.A.,McFadden G.I.,Cummings L.M.,Subramanian G.M.,Mungall C.,Venter J.C.,Carucci D.J.,Hoffman S.L.,Newbold C.,Davis R.W.,Fraser C.M.,Barrell B.G.
Genome sequence of the human malaria parasite Plasmodium falciparum.
Nature
419
498-511
2002
611158
Hall N.,Pain A.,Berriman M.,Churcher C.M.,Harris B.,Harris D.,Mungall K.L.,Bowman S.,Atkin R.,Baker S.,Barron A.,Brooks K.,Buckee C.O.,Burrows C.,Cherevach I.,Chillingworth C.,Chillingworth T.,Christodoulou Z.,Clark L.,Clark R.,Corton C.,Cronin A.,Davies R.M.,Davis P.,Dear P.,Dearden F.,Doggett J.,Feltwell T.,Goble A.,Goodhead I.,Gwilliam R.,Hamlin N.,Hance Z.,Harper D.,Hauser H.,Hornsby T.,Holroyd S.,Horrocks P.,Humphray S.,Jagels K.,James K.D.,Johnson D.,Kerhornou A.,Knights A.,Konfortov B.,Kyes S.,Larke N.,Lawson D.,Lennard N.,Line A.,Maddison M.,Mclean J.,Mooney P.,Moule S.,Murphy L.,Oliver K.,Ormond D.,Price C.,Quail M.A.,Rabbinowitsch E.,Rajandream M.A.,Rutter S.,Rutherford K.M.,Sanders M.,Simmonds M.,Seeger K.,Sharp S.,Smith R.,Squares R.,Squares S.,Stevens K.,Taylor K.,Tivey A.,Unwin L.,Whitehead S.,Woodward J.R.,Sulston J.E.,Craig A.,Newbold C.,Barrell B.G.
Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.
Nature
419
527-531
2002
611159
Freitas-Junior L.H.,Hernandez-Rivas R.,Ralph S.A.,Montiel-Condado D.,Ruvalcaba-Salazar O.K.,Rojas-Meza A.P.,Mancio-Silva L.,Leal-Silvestre R.J.,Gontijo A.M.,Shorte S.,Scherf A.
Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites.
Cell
121
25-36
2005
611160
Merrick C.J.,Duraisingh M.T.
Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity.
Eukaryot. Cell
6
2081-2091
2007
611161
French J.B.,Cen Y.,Sauve A.A.
Plasmodium falciparum Sir2 is an NAD+-dependent deacetylase and an acetyllysine-dependent and acetyllysine-independent NAD+ glycohydrolase.
Biochemistry
47
10227-10239
2008
611162
Prusty D.,Mehra P.,Srivastava S.,Shivange A.V.,Gupta A.,Roy N.,Dhar S.K.
Nicotinamide inhibits Plasmodium falciparum Sir2 activity in vitro and parasite growth.
FEMS Microbiol. Lett.
282
266-272
2008
611163
Mancio-Silva L.,Rojas-Meza A.P.,Vargas M.,Scherf A.,Hernandez-Rivas R.
Differential association of Orc1 and Sir2 proteins to telomeric domains in Plasmodium falciparum.
J. Cell Sci.
121
2046-2053
2008
611164
Chakrabarty S.P.,Saikumari Y.K.,Bopanna M.P.,Balaram H.
Biochemical characterization of Plasmodium falciparum Sir2, a NAD+-dependent deacetylase.
Mol. Biochem. Parasitol.
158
139-151
2008
611165
Tonkin C.J.,Carret C.K.,Duraisingh M.T.,Voss T.S.,Ralph S.A.,Hommel M.,Duffy M.F.,Silva L.M.,Scherf A.,Ivens A.,Speed T.P.,Beeson J.G.,Cowman A.F.
Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum.
PLoS Biol.
7
0-0
2009
611166
Chakrabarty S.P.,Balaram H.
Reversible binding of zinc in Plasmodium falciparum Sir2: structure and activity of the apoenzyme.
Biochim. Biophys. Acta
1804
1743-1750
2010
611167
Deshmukh A.S.,Srivastava S.,Herrmann S.,Gupta A.,Mitra P.,Gilberger T.W.,Dhar S.K.
The role of N-terminus of Plasmodium falciparum ORC1 in telomeric localization and var gene silencing.
Nucleic Acids Res.
40
5313-5331
2012
611169
Zhu A.Y.,Zhou Y.,Khan S.,Deitsch K.W.,Hao Q.,Lin H.
Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine.
ACS Chem. Biol.
7
155-159
2012