Sequence of PRIPO_HUMAN

DNA primase AEP

Q96LW4

560

64412

716044

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

716045

Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.

The full-ORF clone resource of the German cDNA consortium.

BMC Genomics

8

399-399

2007

716046

Hillier L.W.,Graves T.A.,Fulton R.S.,Fulton L.A.,Pepin K.H.,Minx P.,Wagner-McPherson C.,Layman D.,Wylie K.,Sekhon M.,Becker M.C.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Kremitzki C.,Oddy L.,Du H.,Sun H.,Bradshaw-Cordum H.,Ali J.,Carter J.,Cordes M.,Harris A.,Isak A.,van Brunt A.,Nguyen C.,Du F.,Courtney L.,Kalicki J.,Ozersky P.,Abbott S.,Armstrong J.,Belter E.A.,Caruso L.,Cedroni M.,Cotton M.,Davidson T.,Desai A.,Elliott G.,Erb T.,Fronick C.,Gaige T.,Haakenson W.,Haglund K.,Holmes A.,Harkins R.,Kim K.,Kruchowski S.S.,Strong C.M.,Grewal N.,Goyea E.,Hou S.,Levy A.,Martinka S.,Mead K.,McLellan M.D.,Meyer R.,Randall-Maher J.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Shah N.,Swearengen-Shahid S.,Snider J.,Strong J.T.,Thompson J.,Yoakum M.,Leonard S.,Pearman C.,Trani L.,Radionenko M.,Waligorski J.E.,Wang C.,Rock S.M.,Tin-Wollam A.-M.,Maupin R.,Latreille P.,Wendl M.C.,Yang S.-P.,Pohl C.,Wallis J.W.,Spieth J.,Bieri T.A.,Berkowicz N.,Nelson J.O.,Osborne J.,Ding L.,Meyer R.,Sabo A.,Shotland Y.,Sinha P.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Jones T.A.,She X.,Ciccarelli F.D.,Izaurralde E.,Taylor J.,Schmutz J.,Myers R.M.,Cox D.R.,Huang X.,McPherson J.D.,Mardis E.R.,Clifton S.W.,Warren W.C.,Chinwalla A.T.,Eddy S.R.,Marra M.A.,Ovcharenko I.,Furey T.S.,Miller W.,Eichler E.E.,Bork P.,Suyama M.,Torrents D.,Waterston R.H.,Wilson R.K.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

Nature

434

724-731

2005

716048

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

716049

Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal.

2

0-0

2009

716050

Wan L.,Lou J.,Xia Y.,Su B.,Liu T.,Cui J.,Sun Y.,Lou H.,Huang J.

hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity.

EMBO Rep.

14

1104-1112

2013

716051

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

716052

Garcia-Gomez S.,Reyes A.,Martinez-Jimenez M.I.,Chocron E.S.,Mouron S.,Terrados G.,Powell C.,Salido E.,Mendez J.,Holt I.J.,Blanco L.

PrimPol, an archaic primase/polymerase operating in human cells.

Mol. Cell

52

541-553

2013

716053

Bianchi J.,Rudd S.G.,Jozwiakowski S.K.,Bailey L.J.,Soura V.,Taylor E.,Stevanovic I.,Green A.J.,Stracker T.H.,Lindsay H.D.,Doherty A.J.

PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication.

Mol. Cell

52

566-573

2013

716054

Mouron S.,Rodriguez-Acebes S.,Martinez-Jimenez M.I.,Garcia-Gomez S.,Chocron S.,Blanco L.,Mendez J.

Repriming of DNA synthesis at stalled replication forks by human PrimPol.

Nat. Struct. Mol. Biol.

20

1383-1389

2013

716055

Zafar M.K.,Ketkar A.,Lodeiro M.F.,Cameron C.E.,Eoff R.L.

Kinetic analysis of human PrimPol DNA polymerase activity reveals a generally error-prone enzyme capable of accurately bypassing 7,8-dihydro-8-oxo-2'-deoxyguanosine.

Biochemistry

53

6584-6594

2014

716056

Keen B.A.,Jozwiakowski S.K.,Bailey L.J.,Bianchi J.,Doherty A.J.

Molecular dissection of the domain architecture and catalytic activities of human PrimPol.

Nucleic Acids Res.

42

5830-5845

2014

716057

Keen B.A.,Bailey L.J.,Jozwiakowski S.K.,Doherty A.J.

Human PrimPol mutation associated with high myopia has a DNA replication defect.

Nucleic Acids Res.

42

12102-12111

2014

716058

Martinez-Jimenez M.I.,Garcia-Gomez S.,Bebenek K.,Sastre-Moreno G.,Calvo P.A.,Diaz-Talavera A.,Kunkel T.A.,Blanco L.

Alternative solutions and new scenarios for translesion DNA synthesis by human PrimPol.

DNA Repair

29

127-138

2015

716059

Li J.,Zhang Q.

PRIMPOL mutation: functional study does not always reveal the truth.

Invest. Ophthalmol. Vis. Sci.

56

1181-1182

2015

716060

Keen B.A.,Bailey L.J.,Jozwiakowski S.K.,Doherty A.J.

Author response: PRIMPOL mutation: functional study does not always reveal the truth.

Invest. Ophthalmol. Vis. Sci.

56

1183-1183

2015

716061

Guilliam T.A.,Jozwiakowski S.K.,Ehlinger A.,Barnes R.P.,Rudd S.G.,Bailey L.J.,Skehel J.M.,Eckert K.A.,Chazin W.J.,Doherty A.J.

Human PrimPol is a highly error-prone polymerase regulated by single-stranded DNA binding proteins.

Nucleic Acids Res.

43

1056-1068

2015

716062

Schiavone D.,Jozwiakowski S.K.,Romanello M.,Guilbaud G.,Guilliam T.A.,Bailey L.J.,Sale J.E.,Doherty A.J.

PrimPol is required for replicative tolerance of G quadruplexes in vertebrate cells.

Mol. Cell

61

161-169

2016

716063

Guilliam T.A.,Bailey L.J.,Brissett N.C.,Doherty A.J.

PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities.

Nucleic Acids Res.

44

3317-3329

2016

716064

Tokarsky E.J.,Wallenmeyer P.C.,Phi K.K.,Suo Z.

Significant impact of divalent metal ions on the fidelity, sugar selectivity, and drug incorporation efficiency of human PrimPol.

DNA Repair

49

51-59

2017

716065

Martinez-Jimenez M.I.,Lahera A.,Blanco L.

Human PrimPol activity is enhanced by RPA.

Sci. Rep.

7

783-783

2017

716066

Svikovic S.,Crisp A.,Tan-Wong S.M.,Guilliam T.A.,Doherty A.J.,Proudfoot N.J.,Guilbaud G.,Sale J.E.

R-loop formation during S phase is restricted by PrimPol-mediated repriming.

EMBO J.

38

0-0

2019

716067

Martinez-Jimenez M.I.,Calvo P.A.,Garcia-Gomez S.,Guerra-Gonzalez S.,Blanco L.

The Zn-finger domain of human PrimPol is required to stabilize the initiating nucleotide during DNA priming.

Nucleic Acids Res.

46

4138-4151

2018

716068

Calvo P.A.,Sastre-Moreno G.,Perpina C.,Guerra S.,Martinez-Jimenez M.I.,Blanco L.

The invariant glutamate of human PrimPol DxE motif is critical for its Mn2+-dependent distinctive activities.

DNA Repair

77

65-75

2019

716069

Xu W.,Zhao W.,Morehouse N.,Tree M.O.,Zhao L.

Divalent cations alter the rate-limiting step of PrimPol-catalyzed DNA elongation.

J. Mol. Biol.

431

673-686

2019

716070

Quinet A.,Tirman S.,Jackson J.,Svikovic S.,Lemacon D.,Carvajal-Maldonado D.,Gonzalez-Acosta D.,Vessoni A.T.,Cybulla E.,Wood M.,Tavis S.,Batista L.F.Z.,Mendez J.,Sale J.E.,Vindigni A.

PRIMPOL-mediated adaptive response suppresses replication fork reversal in BRCA-deficient cells.

Mol. Cell

0

0-0

2019

716071

Bailey L.J.,Bianchi J.,Doherty A.J.

PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells.

Nucleic Acids Res.

47

4026-4038

2019

716072

Rechkoblit O.,Gupta Y.K.,Malik R.,Rajashankar K.R.,Johnson R.E.,Prakash L.,Prakash S.,Aggarwal A.K.

Structure and mechanism of human PrimPol, a DNA polymerase with primase activity.

Sci. Adv.

2

0-0

2016

716073

Guilliam T.A.,Brissett N.C.,Ehlinger A.,Keen B.A.,Kolesar P.,Taylor E.M.,Bailey L.J.,Lindsay H.D.,Chazin W.J.,Doherty A.J.

Molecular basis for PrimPol recruitment to replication forks by RPA.

Nat. Commun.

8

15222-15222

2017

716074

Zhao F.,Wu J.,Xue A.,Su Y.,Wang X.,Lu X.,Zhou Z.,Qu J.,Zhou X.

Exome sequencing reveals CCDC111 mutation associated with high myopia.

Hum. Genet.

132

913-921

2013