Sequence of EDEM3_MOUSE
EC Number:3.2.1.209
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Man9GlcNAc2-[protein] + H2O = Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,3) + D-mannopyranose
Other sequences found for EC No. 3.2.1.209
General information:
Sequence
0 MSKAGGCRGC GCRVPQRASW SLVAATAALC LVLATSVCTA GAAPMSREEK QKLGNQVLEM
60 FDHAYGNYME HAYPADELMP LTCRGRVRGQ EPSRGDVDDA LGKFSLTLID SLDTLVVLNK
120 TKEFEDAVRK VLRDVNLDND VVVSVFETNI RVLGGLLGGH SLAIMLKEKG EHMQWYNDEL
180 LHMAKQLGYK LLPAFNTTSG LPYPRINLKF GIRKPEARTG TETDTCTACA GTLILEFAAL
240 SRFTGATIFE EYARKALDFL WEKRQRSSNL VGVTINIHTG DWVRKDSGVG AGIDSYYEYL
300 LKAYVLLGDD SFLERFNTHY DAIMRYISQP PLLLDVHIHK PMLNARTWMD ALLAFFPGLQ
360 VLKGDIRPAI ETHEMLYQVI KKHNFLPEAF TTDFRVHWAQ HPLRPEFAES TYFLYKATGD
420 PYYLEVGKTL IENLNKYARV PCGFAAMKDV RTGSHEDRMD SFFLAEMFKY LYLLFADKED
480 IIFDIEDYIF TTEAHLLPLW LSTTNRSISK KNTTSEYTEL DDSNFDWTCP NTQILFPNDP
540 LYAQSIREPL KNVVDKSCPR GIIRVEESFR SGAKPPLRAR DFMATNPEHL EILKKMGVSL
600 IHLKDGRVQL VQHAIQAASS IDAEDGLRFM QEMIELSSQQ QKEQQLPPRA VQIISHPFFG
660 RVVLTAGPAQ FGLDLSKHKE TRGFVASSKP YNGCSELTNP EAVMGKIALI QRGQCMFAEK
720 ARNIQNAGAI GGIVIDDNEG SSSDTAPLFQ MAGDGKDTDD IKIPMLFLFS KEGSIILDAI
780 REHEQVEVLL SDKARDRDPE MENEDQPSSE NDSQNQSAEQ MLSLSQTVDL ADKESPEHPA
840 DSHSEASPSD SEEAAGFAPS EQISGSTENH ETTSLDGECT DLDNQVQEQS ETEEDSSPNV
900 SWGTKAQPID SILADWNEDI EAFEMMEKDE L
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
28735
Hirao K.,Natsuka Y.,Tamura T.,Wada I.,Morito D.,Natsuka S.,Romero P.,Sleno B.,Tremblay L.O.,Herscovics A.,Nagata K.,Hosokawa N.
EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming.
J. Biol. Chem.
281
9650-9658
2006
28736
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
28737
Olivari S.,Molinari M.
Glycoprotein folding and the role of EDEM1, EDEM2 and EDEM3 in degradation of folding-defective glycoproteins.
FEBS Lett.
581
3658-3664
2007
28738
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
28739
Polla D.L.,Edmondson A.C.,Duvet S.,March M.E.,Sousa A.B.,Lehman A.,Niyazov D.,van Dijk F.,Demirdas S.,van Slegtenhorst M.A.,Kievit A.J.A.,Schulz C.,Armstrong L.,Bi X.,Rader D.J.,Izumi K.,Zackai E.H.,de Franco E.,Jorge P.,Huffels S.C.,Hommersom M.,Ellard S.,Lefeber D.J.,Santani A.,Hand N.J.,van Bokhoven H.,He M.,de Brouwer A.P.M.
Bi-allelic variants in the ER quality-control mannosidase gene EDEM3 cause a congenital disorder of glycosylation.
Am. J. Hum. Genet.
108
1342-1349
2021
