Sequence of CP24A_HUMAN
EC Number:1.14.14.24
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
calciol + O2 + [reduced NADPH-hemoprotein reductase] = calcidiol + [oxidized NADPH-hemoprotein reductase] + H2O
Other sequences found for EC No. 1.14.14.24
General information:
Sequence
0 MSSPISKSRS LAAFLQQLRS PRQPPRLVTS TAYTSPQPRE VPVCPLTAGG ETQNAAALPG
60 PTSWPLLGSL LQILWKGGLK KQHDTLVEYH KKYGKIFRMK LGSFESVHLG SPCLLEALYR
120 TESAYPQRLE IKPWKAYRDY RKEGYGLLIL EGEDWQRVRS AFQKKLMKPG EVMKLDNKIN
180 EVLADFMGRI DELCDERGHV EDLYSELNKW SFESICLVLY EKRFGLLQKN AGDEAVNFIM
240 AIKTMMSTFG RMMVTPVELH KSLNTKVWQD HTLAWDTIFK SVKACIDNRL EKYSQQPSAD
300 FLCDIYHQNR LSKKELYAAV TELQLAAVET TANSLMWILY NLSRNPQVQQ KLLKEIQSVL
360 PENQVPRAED LRNMPYLKAC LKESMRLTPS VPFTTRTLDK ATVLGEYALP KGTVLMLNTQ
420 VLGSSEDNFE DSSQFRPERW LQEKEKINPF AHLPFGVGKR MCIGRRLAEL QLHLALCWIV
480 RKYDIQATDN EPVEMLHSGT LVPSRELPIA FCQR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
279258
Chen K.-S.,Prahl J.M.,Deluca H.F.
Isolation and expression of human 1,25-dihydroxyvitamin D3 24-hydroxylase cDNA.
Proc. Natl. Acad. Sci. U.S.A.
90
4543-4547
1993
279259
Ren S.,Nguyen L.,Wu S.,Encinas C.,Adams J.S.,Hewison M.
Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis.
J. Biol. Chem.
280
20604-20611
2005
279260
Deloukas P.,Matthews L.H.,Ashurst J.L.,Burton J.,Gilbert J.G.R.,Jones M.,Stavrides G.,Almeida J.P.,Babbage A.K.,Bagguley C.L.,Bailey J.,Barlow K.F.,Bates K.N.,Beard L.M.,Beare D.M.,Beasley O.P.,Bird C.P.,Blakey S.E.,Bridgeman A.M.,Brown A.J.,Buck D.,Burrill W.D.,Butler A.P.,Carder C.,Carter N.P.,Chapman J.C.,Clamp M.,Clark G.,Clark L.N.,Clark S.Y.,Clee C.M.,Clegg S.,Cobley V.E.,Collier R.E.,Connor R.E.,Corby N.R.,Coulson A.,Coville G.J.,Deadman R.,Dhami P.D.,Dunn M.,Ellington A.G.,Frankland J.A.,Fraser A.,French L.,Garner P.,Grafham D.V.,Griffiths C.,Griffiths M.N.D.,Gwilliam R.,Hall R.E.,Hammond S.,Harley J.L.,Heath P.D.,Ho S.,Holden J.L.,Howden P.J.,Huckle E.,Hunt A.R.,Hunt S.E.,Jekosch K.,Johnson C.M.,Johnson D.,Kay M.P.,Kimberley A.M.,King A.,Knights A.,Laird G.K.,Lawlor S.,Lehvaeslaiho M.H.,Leversha M.A.,Lloyd C.,Lloyd D.M.,Lovell J.D.,Marsh V.L.,Martin S.L.,McConnachie L.J.,McLay K.,McMurray A.A.,Milne S.A.,Mistry D.,Moore M.J.F.,Mullikin J.C.,Nickerson T.,Oliver K.,Parker A.,Patel R.,Pearce T.A.V.,Peck A.I.,Phillimore B.J.C.T.,Prathalingam S.R.,Plumb R.W.,Ramsay H.,Rice C.M.,Ross M.T.,Scott C.E.,Sehra H.K.,Shownkeen R.,Sims S.,Skuce C.D.,Smith M.L.,Soderlund C.,Steward C.A.,Sulston J.E.,Swann R.M.,Sycamore N.,Taylor R.,Tee L.,Thomas D.W.,Thorpe A.,Tracey A.,Tromans A.C.,Vaudin M.,Wall M.,Wallis J.M.,Whitehead S.L.,Whittaker P.,Willey D.L.,Williams L.,Williams S.A.,Wilming L.,Wray P.W.,Hubbard T.,Durbin R.M.,Bentley D.R.,Beck S.,Rogers J.
The DNA sequence and comparative analysis of human chromosome 20.
Nature
414
865-871
2001
279261
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
279262
Chen K.-S.,DeLuca H.F.
Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements.
Biochim. Biophys. Acta
1263
1-9
1995
279263
Labuda M.,Lemieux N.,Tihy F.,Prinster C.,Glorieux F.H.
Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450 subunit maps to a different chromosomal location than that of pseudovitamin D-deficient rickets.
J. Bone Miner. Res.
8
1397-1406
1993
279264
Beckman M.J.,Tadikonda P.,Werner E.,Prahl J.,Yamada S.,DeLuca H.F.
Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme.
Biochemistry
35
8465-8472
1996
279265
Sakaki T.,Sawada N.,Komai K.,Shiozawa S.,Yamada S.,Yamamoto K.,Ohyama Y.,Inouye K.
Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24.
Eur. J. Biochem.
267
6158-6165
2000
279266
Sakaki T.,Kagawa N.,Yamamoto K.,Inouye K.
Metabolism of vitamin D3 by cytochromes P450.
Front. Biosci.
10
119-134
2005
279267
Hamamoto H.,Kusudo T.,Urushino N.,Masuno H.,Yamamoto K.,Yamada S.,Kamakura M.,Ohta M.,Inouye K.,Sakaki T.
Structure-function analysis of vitamin D 24-hydroxylase (CYP24A1) by site-directed mutagenesis: amino acid residues responsible for species-based difference of CYP24A1 between humans and rats.
Mol. Pharmacol.
70
120-128
2006
279268
Tieu E.W.,Tang E.K.,Tuckey R.C.
Kinetic analysis of human CYP24A1 metabolism of vitamin D via the C24-oxidation pathway.
FEBS J.
281
3280-3296
2014
279269
Tieu E.W.,Li W.,Chen J.,Kim T.K.,Ma D.,Slominski A.T.,Tuckey R.C.
Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1.
J. Steroid Biochem. Mol. Biol.
149
153-165
2015
279270
Roizen J.D.,Li D.,O'Lear L.,Javaid M.K.,Shaw N.J.,Ebeling P.R.,Nguyen H.H.,Rodda C.P.,Thummel K.E.,Thacher T.D.,Hakonarson H.,Levine M.A.
CYP3A4 mutation causes vitamin D-dependent rickets type 3.
J. Clin. Invest.
128
1913-1918
2018
279271
Schlingmann K.P.,Kaufmann M.,Weber S.,Irwin A.,Goos C.,John U.,Misselwitz J.,Klaus G.,Kuwertz-Broking E.,Fehrenbach H.,Wingen A.M.,Guran T.,Hoenderop J.G.,Bindels R.J.,Prosser D.E.,Jones G.,Konrad M.
Mutations in CYP24A1 and idiopathic infantile hypercalcemia.
N. Engl. J. Med.
365
410-421
2011
