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Sequence of CDKA1_ARATH

EC Number:2.7.11.22

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
cyclin-dependent kinase
P24100
Arabidopsis thaliana
294
34030
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.22

General information:

Sequence
show sequence in fasta format
  0 MDQYEKVEKI GEGTYGVVYK ARDKVTNETI ALKKIRLEQE DEGVPSTAIR EISLLKEMQH
 60 SNIVKLQDVV HSEKRLYLVF EYLDLDLKKH MDSTPDFSKD LHMIKTYLYQ ILRGIAYCHS
120 HRVLHRDLKP QNLLIDRRTN SLKLADFGLA RAFGIPVRTF THEVVTLWYR APEILLGSHH
180 YSTPVDIWSV GCIFAEMISQ KPLFPGDSEI DQLFKIFRIM GTPYEDTWRG VTSLPDYKSA
240 FPKWKPTDLE TFVPNLDPDG VDLLSKMLLM DPTKRINARA ALEHEYFKDL GGMP
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
15480
Hirayama T.,Imajuku Y.,Anai T.,Matsui M.,Oka A.
Identification of two cell-cycle-controlling cdc2 gene homologs in Arabidopsis thaliana.
Gene
105
159-165
1991
15481
Ferreira P.C.G.,Hemerly A.S.,Villarroel R.,van Montagu M.,Inze D.
The Arabidopsis functional homolog of the p34cdc2 protein kinase.
Plant Cell
3
531-540
1991
15482
Inze D.,Ferreira P.C.G.,Hemerly A.S.,van Montagu M.
Control of cell division in plants.
Biochem. Soc. Trans.
20
80-84
1992
15483
Imajuku Y.,Hirayama T.,Endoh H.,Oka A.
Exon-intron organization of the Arabidopsis thaliana protein kinase genes CDC2a and CDC2b.
FEBS Lett.
304
73-77
1992
15484
Salanoubat M.,Lemcke K.,Rieger M.,Ansorge W.,Unseld M.,Fartmann B.,Valle G.,Bloecker H.,Perez-Alonso M.,Obermaier B.,Delseny M.,Boutry M.,Grivell L.A.,Mache R.,Puigdomenech P.,De Simone V.,Choisne N.,Artiguenave F.,Robert C.,Brottier P.,Wincker P.,Cattolico L.,Weissenbach J.,Saurin W.,Quetier F.,Schaefer M.,Mueller-Auer S.,Gabel C.,Fuchs M.,Benes V.,Wurmbach E.,Drzonek H.,Erfle H.,Jordan N.,Bangert S.,Wiedelmann R.,Kranz H.,Voss H.,Holland R.,Brandt P.,Nyakatura G.,Vezzi A.,D'Angelo M.,Pallavicini A.,Toppo S.,Simionati B.,Conrad A.,Hornischer K.,Kauer G.,Loehnert T.-H.,Nordsiek G.,Reichelt J.,Scharfe M.,Schoen O.,Bargues M.,Terol J.,Climent J.,Navarro P.,Collado C.,Perez-Perez A.,Ottenwaelder B.,Duchemin D.,Cooke R.,Laudie M.,Berger-Llauro C.,Purnelle B.,Masuy D.,de Haan M.,Maarse A.C.,Alcaraz J.-P.,Cottet A.,Casacuberta E.,Monfort A.,Argiriou A.,Flores M.,Liguori R.,Vitale D.,Mannhaupt G.,Haase D.,Schoof H.,Rudd S.,Zaccaria P.,Mewes H.-W.,Mayer K.F.X.,Kaul S.,Town C.D.,Koo H.L.,Tallon L.J.,Jenkins J.,Rooney T.,Rizzo M.,Walts A.,Utterback T.,Fujii C.Y.,Shea T.P.,Creasy T.H.,Haas B.,Maiti R.,Wu D.,Peterson J.,Van Aken S.,Pai G.,Militscher J.,Sellers P.,Gill J.E.,Feldblyum T.V.,Preuss D.,Lin X.,Nierman W.C.,Salzberg S.L.,White O.,Venter J.C.,Fraser C.M.,Kaneko T.,Nakamura Y.,Sato S.,Kato T.,Asamizu E.,Sasamoto S.,Kimura T.,Idesawa K.,Kawashima K.,Kishida Y.,Kiyokawa C.,Kohara M.,Matsumoto M.,Matsuno A.,Muraki A.,Nakayama S.,Nakazaki N.,Shinpo S.,Takeuchi C.,Wada T.,Watanabe A.,Yamada M.,Yasuda M.,Tabata S.
Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.
Nature
408
820-822
2000
15485
Cheng C.Y.,Krishnakumar V.,Chan A.P.,Thibaud-Nissen F.,Schobel S.,Town C.D.
Araport11: a complete reannotation of the Arabidopsis thaliana reference genome.
Plant J.
89
789-804
2017
15486
Yamada K.,Lim J.,Dale J.M.,Chen H.,Shinn P.,Palm C.J.,Southwick A.M.,Wu H.C.,Kim C.J.,Nguyen M.,Pham P.K.,Cheuk R.F.,Karlin-Newmann G.,Liu S.X.,Lam B.,Sakano H.,Wu T.,Yu G.,Miranda M.,Quach H.L.,Tripp M.,Chang C.H.,Lee J.M.,Toriumi M.J.,Chan M.M.,Tang C.C.,Onodera C.S.,Deng J.M.,Akiyama K.,Ansari Y.,Arakawa T.,Banh J.,Banno F.,Bowser L.,Brooks S.Y.,Carninci P.,Chao Q.,Choy N.,Enju A.,Goldsmith A.D.,Gurjal M.,Hansen N.F.,Hayashizaki Y.,Johnson-Hopson C.,Hsuan V.W.,Iida K.,Karnes M.,Khan S.,Koesema E.,Ishida J.,Jiang P.X.,Jones T.,Kawai J.,Kamiya A.,Meyers C.,Nakajima M.,Narusaka M.,Seki M.,Sakurai T.,Satou M.,Tamse R.,Vaysberg M.,Wallender E.K.,Wong C.,Yamamura Y.,Yuan S.,Shinozaki K.,Davis R.W.,Theologis A.,Ecker J.R.
Empirical analysis of transcriptional activity in the Arabidopsis genome.
Science
302
842-846
2003
15490
Segers G.,Gadisseur I.,Bergounioux C.,de Almeida Engler J.,Jacqmard A.,van Montagu M.,Inze D.
The Arabidopsis cyclin-dependent kinase gene cdc2bAt is preferentially expressed during S and G2 phases of the cell cycle.
Plant J.
10
601-612
1996
15491
Niebel A.,de Almeida Engler J.,Hemerly A.S.,Ferreira P.C.G.,Inze D.,van Montagu M.,Gheysen G.
Induction of cdc2a and cyc1At expression in Arabidopsis thaliana during early phases of nematode-induced feeding cell formation.
Plant J.
10
1037-1043
1996
15492
de Veylder L.,Segers G.,Glab N.,Casteels P.,van Montagu M.,Inze D.
The Arabidopsis Cks1At protein binds the cyclin-dependent kinases Cdc2aAt and Cdc2bAt.
FEBS Lett.
412
446-452
1997
15493
Wang H.,Fowke L.C.,Crosby W.L.
A plant cyclin-dependent kinase inhibitor gene.
Nature
386
451-452
1997
15494
Wang H.,Qi Q.,Schorr P.,Cutler A.J.,Crosby W.L.,Fowke L.C.
ICK1, a cyclin-dependent protein kinase inhibitor from Arabidopsis thaliana interacts with both Cdc2a and CycD3, and its expression is induced by abscisic acid.
Plant J.
15
501-510
1998
15495
Porceddu A.,de Veylder L.,Hayles J.,van Montagu M.,Inze D.,Mironov V.
Mutational analysis of two Arabidopsis thaliana cyclin-dependent kinases in fission yeast.
FEBS Lett.
446
182-188
1999
15496
de Veylder L.,de Almeida Engler J.,Burssens S.,Manevski A.,Lescure B.,van Montagu M.,Engler G.,Inze D.
A new D-type cyclin of Arabidopsis thaliana expressed during lateral root primordia formation.
Planta
208
453-462
1999
15497
Yoshizumi T.,Nagata N.,Shimada H.,Matsui M.
An Arabidopsis cell cycle-dependent kinase-related gene, CDC2b, plays a role in regulating seedling growth in darkness.
Plant Cell
11
1883-1896
1999
15498
Burssens S.,Himanen K.,van de Cotte B.,Beeckman T.,van Montagu M.,Inze D.,Verbruggen N.
Expression of cell cycle regulatory genes and morphological alterations in response to salt stress in Arabidopsis thaliana.
Planta
211
632-640
2000
15499
Lui H.,Wang H.,Delong C.,Fowke L.C.,Crosby W.L.,Fobert P.R.
The Arabidopsis Cdc2a-interacting protein ICK2 is structurally related to ICK1 and is a potent inhibitor of cyclin-dependent kinase activity in vitro.
Plant J.
21
379-385
2000
15500
Hemerly A.S.,Ferreira P.C.G.,van Montagu M.,Engler G.,Inze D.
Cell division events are essential for embryo patterning and morphogenesis: studies on dominant-negative cdc2aAt mutants of Arabidopsis.
Plant J.
23
123-130
2000
15501
Healy J.M.S.,Menges M.,Doonan J.H.,Murray J.A.H.
The Arabidopsis D-type cyclins CycD2 and CycD3 both interact in vivo with the PSTAIRE cyclin-dependent kinase Cdc2a but are differentially controlled.
J. Biol. Chem.
276
7041-7047
2001
15502
de Veylder L.,Beeckman T.,Beemster G.T.S.,Krols L.,Terras F.,Landrieu I.,van der Schueren E.,Maes S.,Naudts M.,Inze D.
Functional analysis of cyclin-dependent kinase inhibitors of Arabidopsis.
Plant Cell
13
1653-1667
2001
15503
de Veylder L.,Beemster G.T.S.,Beeckman T.,Inze D.
CKS1At overexpression in Arabidopsis thaliana inhibits growth by reducing meristem size and inhibiting cell-cycle progression.
Plant J.
25
617-626
2001
15504
Boniotti M.B.,Gutierrez C.
A cell-cycle-regulated kinase activity phosphorylates plant retinoblastoma protein and contains, in Arabidopsis, a CDKA/cyclin D complex.
Plant J.
28
341-350
2001
15505
Vandepoele K.,Raes J.,de Veylder L.,Rouze P.,Rombauts S.,Inze D.
Genome-wide analysis of core cell cycle genes in Arabidopsis.
Plant Cell
14
903-916
2002
15506
Schnittger A.,Weinl C.,Bouyer D.,Schoebinger U.,Huelskamp M.
Misexpression of the cyclin-dependent kinase inhibitor ICK1/KRP1 in single-celled Arabidopsis trichomes reduces endoreduplication and cell size and induces cell death.
Plant Cell
15
303-315
2003
15507
Kono A.,Umeda-Hara C.,Lee J.,Ito M.,Uchimiya H.,Umeda M.
Arabidopsis D-type cyclin CYCD4;1 is a novel cyclin partner of B2-type cyclin-dependent kinase.
Plant Physiol.
132
1315-1321
2003
15508
Hutchins A.P.,Roberts G.R.,Lloyd C.W.,Doonan J.H.
In vivo interaction between CDKA and eIF4A: a possible mechanism linking translation and cell proliferation.
FEBS Lett.
556
91-94
2004
15509
Torres Acosta J.A.,de Almeida Engler J.,Raes J.,Magyar Z.,de Groodt R.,Inze D.,de Veylder L.
Molecular characterization of Arabidopsis PHO80-like proteins, a novel class of CDKA;1-interacting cyclins.
Cell. Mol. Life Sci.
61
1485-1497
2004
15510
del Mar Castellano M.,Boniotti M.B.,Caro E.,Schnittger A.,Gutierrez C.
DNA replication licensing affects cell proliferation or endoreplication in a cell type-specific manner.
Plant Cell
16
2380-2393
2004
15511
Shimotohno A.,Umeda-Hara C.,Bisova K.,Uchimiya H.,Umeda M.
The plant-specific kinase CDKF;1 is involved in activating phosphorylation of cyclin-dependent kinase-activating kinases in Arabidopsis.
Plant Cell
16
2954-2966
2004
15512
Verkest A.,de Oliveira Manes C.L.,Vercruysse S.,Maes S.,van der Schueren E.,Beeckman T.,Genschik P.,Kuiper M.,Inze D.,de Veylder L.
The cyclin-dependent kinase inhibitor KRP2 controls the onset of the endoreduplication cycle during Arabidopsis leaf development through inhibition of mitotic CDKA;1 kinase complexes.
Plant Cell
17
1723-1736
2005
15513
Inze D.,de Veylder L.
Cell cycle regulation in plant development.
Annu. Rev. Genet.
40
77-105
2006
15514
Nakai T.,Kato K.,Shinmyo A.,Sekine M.
Arabidopsis KRPs have distinct inhibitory activity toward cyclin D2-associated kinases, including plant-specific B-type cyclin-dependent kinase.
FEBS Lett.
580
336-340
2006
15515
Imai K.K.,Ohashi Y.,Tsuge T.,Yoshizumi T.,Matsui M.,Oka A.,Aoyama T.
The A-type cyclin CYCA2;3 is a key regulator of ploidy levels in Arabidopsis endoreduplication.
Plant Cell
18
382-396
2006
15516
Menges M.,Samland A.K.,Planchais S.,Murray J.A.H.
The D-type cyclin CYCD3;1 is limiting for the G1-to-S-phase transition in Arabidopsis.
Plant Cell
18
893-906
2006
15517
Da Costa M.,Bach L.,Landrieu I.,Bellec Y.,Catrice O.,Brown S.,De Veylder L.,Lippens G.,Inze D.,Faure J.-D.
Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase A.
Plant Cell
18
1426-1437
2006
15518
Kono A.,Ohno R.,Umeda-Hara C.,Uchimiya H.,Umeda M.
A distinct type of cyclin D, CYCD4;2, involved in the activation of cell division in Arabidopsis.
Plant Cell Rep.
25
540-545
2006
15519
Iwakawa H.,Shinmyo A.,Sekine M.
Arabidopsis CDKA;1, a cdc2 homologue, controls proliferation of generative cells in male gametogenesis.
Plant J.
45
819-831
2006
15520
Shimotohno A.,Ohno R.,Bisova K.,Sakaguchi N.,Huang J.,Koncz C.,Uchimiya H.,Umeda M.
Diverse phosphoregulatory mechanisms controlling cyclin-dependent kinase-activating kinases in Arabidopsis.
Plant J.
47
701-710
2006
15521
Zhou Y.,Niu H.,Brandizzi F.,Fowke L.C.,Wang H.
Molecular control of nuclear and subnuclear targeting of the plant CDK inhibitor ICK1 and ICK1-mediated nuclear transport of CDKA.
Plant Mol. Biol.
62
261-278
2006
15522
de Schutter K.,Joubes J.,Cools T.,Verkest A.,Corellou F.,Babiychuk E.,van der Schueren E.,Beeckman T.,Kushnir S.,Inze D.,de Veylder L.
Arabidopsis WEE1 kinase controls cell cycle arrest in response to activation of the DNA integrity checkpoint.
Plant Cell
19
211-225
2007
15523
Dissmeyer N.,Nowack M.K.,Pusch S.,Stals H.,Inze D.,Grini P.E.,Schnittger A.
T-loop phosphorylation of Arabidopsis CDKA;1 is required for its function and can be partially substituted by an aspartate residue.
Plant Cell
19
972-985
2007
15524
de la Fuente van Bentem S.,Anrather D.,Dohnal I.,Roitinger E.,Csaszar E.,Joore J.,Buijnink J.,Carreri A.,Forzani C.,Lorkovic Z.J.,Barta A.,Lecourieux D.,Verhounig A.,Jonak C.,Hirt H.
Site-specific phosphorylation profiling of Arabidopsis proteins by mass spectrometry and peptide chip analysis.
J. Proteome Res.
7
2458-2470
2008
15525
Jones A.M.E.,MacLean D.,Studholme D.J.,Serna-Sanz A.,Andreasson E.,Rathjen J.P.,Peck S.C.
Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis thaliana.
J. Proteomics
72
439-451
2009
15526
Reiland S.,Messerli G.,Baerenfaller K.,Gerrits B.,Endler A.,Grossmann J.,Gruissem W.,Baginsky S.
Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks.
Plant Physiol.
150
889-903
2009
15527
Van Leene J.,Hollunder J.,Eeckhout D.,Persiau G.,Van De Slijke E.,Stals H.,Van Isterdael G.,Verkest A.,Neirynck S.,Buffel Y.,De Bodt S.,Maere S.,Laukens K.,Pharazyn A.,Ferreira P.C.G.,Eloy N.,Renne C.,Meyer C.,Faure J.-D.,Steinbrenner J.,Beynon J.,Larkin J.C.,Van de Peer Y.,Hilson P.,Kuiper M.,De Veylder L.,Van Onckelen H.,Inze D.,Witters E.,De Jaeger G.
Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana.
Mol. Syst. Biol.
6
397-397
2010
15528
Yang K.,Wang H.,Xue S.,Qu X.,Zou J.,Le J.
Requirement for A-type cyclin-dependent kinase and cyclins for the terminal division in the stomatal lineage of Arabidopsis.
J. Exp. Bot.
65
2449-2461
2014
15529
Kobayashi K.,Suzuki T.,Iwata E.,Nakamichi N.,Suzuki T.,Chen P.,Ohtani M.,Ishida T.,Hosoya H.,Mueller S.,Leviczky T.,Pettko-Szandtner A.,Darula Z.,Iwamoto A.,Nomoto M.,Tada Y.,Higashiyama T.,Demura T.,Doonan J.H.,Hauser M.T.,Sugimoto K.,Umeda M.,Magyar Z.,Boegre L.,Ito M.
Transcriptional repression by MYB3R proteins regulates plant organ growth.
EMBO J.
34
1992-2007
2015
15530
Yang K.-Z.,Jiang M.,Wang M.,Xue S.,Zhu L.-L.,Wang H.-Z.,Zou J.-J.,Lee E.-K.,Sack F.,Le J.
Phosphorylation of serine 186 of bHLH transcription factor SPEECHLESS promotes stomatal development in Arabidopsis.
Mol. Plant
8
783-795
2015