Sequence of BRSK2_HUMAN

tau-protein kinase

Q8IWQ3

736

81633

139108

Inoue E.,Mochida S.,Takagi H.,Higa S.,Deguchi-Tawarada M.,Takao-Rikitsu E.,Inoue M.,Yao I.,Takeuchi K.,Kitajima I.,Setou M.,Ohtsuka T.,Takai Y.

SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release.

Neuron

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261-275

2006

139110

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

139111

Taylor T.D.,Noguchi H.,Totoki Y.,Toyoda A.,Kuroki Y.,Dewar K.,Lloyd C.,Itoh T.,Takeda T.,Kim D.-W.,She X.,Barlow K.F.,Bloom T.,Bruford E.,Chang J.L.,Cuomo C.A.,Eichler E.,FitzGerald M.G.,Jaffe D.B.,LaButti K.,Nicol R.,Park H.-S.,Seaman C.,Sougnez C.,Yang X.,Zimmer A.R.,Zody M.C.,Birren B.W.,Nusbaum C.,Fujiyama A.,Hattori M.,Rogers J.,Lander E.S.,Sakaki Y.

Human chromosome 11 DNA sequence and analysis including novel gene identification.

Nature

440

497-500

2006

139112

Stanchi F.,Bertocco E.,Toppo S.,Dioguardi R.,Simionati B.,Cannata N.,Zimbello R.,Lanfranchi G.,Valle G.

Characterization of 16 novel human genes showing high similarity to yeast sequences.

Yeast

18

69-80

2001

139113

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

139114

Miura K.,Miyoshi O.,Yun K.,Inazawa J.,Miyamoto T.,Hayashi H.,Masuzaki H.,Yoshimura S.,Niikawa N.,Jinno Y.,Ishimaru T.

Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta.

J. Hum. Genet.

44

1-9

1999

139115

Lizcano J.M.,Goeransson O.,Toth R.,Deak M.,Morrice N.A.,Boudeau J.,Hawley S.A.,Udd L.,Maekelae T.P.,Hardie D.G.,Alessi D.R.

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

EMBO J.

23

833-843

2004

139116

Guo Z.,Tang W.,Yuan J.,Chen X.,Wan B.,Gu X.,Luo K.,Wang Y.,Yu L.

BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260.

Biochem. Biophys. Res. Commun.

347

867-871

2006

139117

Bright N.J.,Carling D.,Thornton C.

Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation.

J. Biol. Chem.

283

14946-14954

2008

139118

Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

Anal. Chem.

81

4493-4501

2009

139119

Oppermann F.S.,Gnad F.,Olsen J.V.,Hornberger R.,Greff Z.,Keri G.,Mann M.,Daub H.

Large-scale proteomics analysis of the human kinome.

Mol. Cell. Proteomics

8

1751-1764

2009

139120

Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal.

2

0-0

2009

139121

Fogarty S.,Hawley S.A.,Green K.A.,Saner N.,Mustard K.J.,Hardie D.G.

Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.

Biochem. J.

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2010

139122

Muller M.,Lutter D.,Puschel A.W.

Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity.

J. Cell Sci.

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286-294

2010

139123

Zhou J.,Wan B.,Li R.,Gu X.,Zhong Z.,Wang Y.,Yu L.

Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway.

Biochem. Biophys. Res. Commun.

422

647-652

2012

139124

Wang Y.,Wan B.,Li D.,Zhou J.,Li R.,Bai M.,Chen F.,Yu L.

BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis.

Biochem. Biophys. Res. Commun.

423

813-818

2012

139125

Nie J.,Sun C.,Faruque O.,Ye G.,Li J.,Liang Q.,Chang Z.,Yang W.,Han X.,Shi Y.

Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic beta-Cells.

J. Biol. Chem.

287

26435-26444

2012

139126

Chen X.Y.,Gu X.T.,Saiyin H.,Wan B.,Zhang Y.J.,Li J.,Wang Y.L.,Gao R.,Wang Y.F.,Dong W.P.,Najjar S.M.,Zhang C.Y.,Ding H.F.,Liu J.O.,Yu L.

Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells.

J. Biol. Chem.

287

30368-30375

2012

139127

Yoshida H.,Goedert M.

Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.

J. Neurochem.

120

165-176

2012

139128

Li R.,Wan B.,Zhou J.,Wang Y.,Luo T.,Gu X.,Chen F.,Yu L.

APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway.

PLoS ONE

7

0-0

2012