Sequence of ATP4A_PIG
EC Number:7.2.2.19
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + H2O + H+[side 1] + K+[side 2] = ADP + phosphate + H+[side 2] + K+[side 1]
Other sequences found for EC No. 7.2.2.19
General information:
Sequence
0 MGKAENYELY QVELGPGPSG DMAAKMSKKK AGRGGGKRKE KLENMKKEME INDHQLSVAE
60 LEQKYQTSAT KGLSASLAAE LLLRDGPNAL RPPRGTPEYV KFARQLAGGL QCLMWVAAAI
120 CLIAFAIQAS EGDLTTDDNL YLALALIAVV VVTGCFGYYQ EFKSTNIIAS FKNLVPQQAT
180 VIRDGDKFQI NADQLVVGDL VEMKGGDRVP ADIRILQAQG RKVDNSSLTG ESEPQTRSPE
240 CTHESPLETR NIAFFSTMCL EGTAQGLVVN TGDRTIIGRI ASLASGVENE KTPIAIEIEH
300 FVDIIAGLAI LFGATFFIVA MCIGYTFLRA MVFFMAIVVA YVPEGLLATV TVCLSLTAKR
360 LASKNCVVKN LEAVETLGST SVICSDKTGT LTQNRMTVSH LWFDNHIHSA DTTEDQSGQT
420 FDQSSETWRA LCRVLTLCNR AAFKSGQDAV PVPKRIVIGD ASETALLKFS ELTLGNAMGY
480 RERFPKVCEI PFNSTNKFQL SIHTLEDPRD PRHVLVMKGA PERVLERCSS ILIKGQELPL
540 DEQWREAFQT AYLSLGGLGE RVLGFCQLYL SEKDYPPGYA FDVEAMNFPT SGLSFAGLVS
600 MIDPPRATVP DAVLKCRTAG IRVIMVTGDH PITAKAIAAS VGIISEGSET VEDIAARLRV
660 PVDQVNRKDA RACVINGMQL KDMDPSELVE ALRTHPEMVF ARTSPQQKLV IVESCQRLGA
720 IVAVTGDGVN DSPALKKADI GVAMGIAGSD AAKNAADMIL LDDNFASIVT GVEQGRLIFD
780 NLKKSIAYTL TKNIPELTPY LIYITVSVPL PLGCITILFI ELCTDIFPSV SLAYEKAESD
840 IMHLRPRNPK RDRLVNEPLA AYSYFQIGAI QSFAGFTDYF TAMAQEGWFP LLCVGLRPQW
900 ENHHLQDLQD SYGQEWTFGQ RLYQQYTCYT VFFISIEMCQ IADVLIRKTR RLSAFQQGFF
960 RNRILVIAIV FQVCIGCFLC YCPGMPNIFN FMPIRFQWWL VPMPFGLLIF VYDEIRKLGV
1020 RCCPGSWWDQ ELYY
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
135468
Maeda M.,Ishizaki J.,Futai M.
cDNA cloning and sequence determination of pig gastric (H+ + K+)-ATPase.
Biochem. Biophys. Res. Commun.
157
203-209
1988
135469
Lane L.K.,Kirley T.L.,Ball W.J. Jr.
Structural studies on H+,K+-ATPase: determination of the NH2-terminal amino acid sequence and immunological cross-reactivity with Na+,K+-ATPase.
Biochem. Biophys. Res. Commun.
138
185-192
1986
135470
Van Uem T.J.,Swarts H.G.,De Pont J.J.
Determination of the epitope for the inhibitory monoclonal antibody 5-B6 on the catalytic subunit of gastric Mg(2+)-dependent H(+)-transporting and K(+)-stimulated ATPase.
Biochem. J.
280
243-248
1991
135471
Togawa K.,Ishiguro T.,Kaya S.,Shimada A.,Imagawa T.,Taniguchi K.
Reversible phosphorylation of both Tyr7 and Tyr10 in the alpha-chain of pig stomach H+,K(+)-ATPase by a membrane-bound kinase and a phosphatase.
J. Biol. Chem.
270
15475-15478
1995
135472
Togawa K.,Kaya S.,Shimada A.,Imagawa T.,Maardh S.,Corbin J.,Kikkawa U.,Taniguchi K.
Ser-27, Tyr-10 and Tyr-7 in the alpha-chain of pig stomach H+,K(+)-ATPase as Ca(2+)-dependent phosphorylatable sites by intrinsic and extrinsic protein kinases.
Biochem. Biophys. Res. Commun.
227
810-815
1996
135473
Dubey V.,Han M.,Kopec W.,Solov'yov I.A.,Abe K.,Khandelia H.
K+ binding and proton redistribution in the E2P state of the H+, K+-ATPase.
Sci. Rep.
8
12732-12732
2018
135474
Abe K.,Tani K.,Nishizawa T.,Fujiyoshi Y.
Inter-subunit interaction of gastric H+,K+-ATPase prevents reverse reaction of the transport cycle.
EMBO J.
28
1637-1643
2009
135475
Abe K.,Tani K.,Fujiyoshi Y.
Conformational rearrangement of gastric H(+),K(+)-ATPase induced by an acid suppressant.
Nat. Commun.
2
155-155
2011
135476
Abe K.,Irie K.,Nakanishi H.,Suzuki H.,Fujiyoshi Y.
Crystal structures of the gastric proton pump.
Nature
556
214-218
2018
135477
Yamamoto K.,Dubey V.,Irie K.,Nakanishi H.,Khandelia H.,Fujiyoshi Y.,Abe K.
A single K(+)-binding site in the crystal structure of the gastric proton pump.
Elife
8
0-0
2019
