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Sequence of C1R_HUMAN

EC Number:3.4.21.41

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
complement subcomponent C1r
P00736
Homo sapiens
705
80119
Reaction
Selective cleavage of Lys(or Arg)-/-Ile bond in complement subcomponent C1s to form C_overbar_1s_ (EC 3.4.21.42)
Other sequences found for EC No. 3.4.21.41

General information:

Sequence
show sequence in fasta format
  0 MWLLYLLVPA LFCRAGGSIP IPQKLFGEVT SPLFPKPYPN NFETTTVITV PTGYRVKLVF
 60 QQFDLEPSEG CFYDYVKISA DKKSLGRFCG QLGSPLGNPP GKKEFMSQGN KMLLTFHTDF
120 SNEENGTIMF YKGFLAYYQA VDLDECASRS KSGEEDPQPQ CQHLCHNYVG GYFCSCRPGY
180 ELQEDTHSCQ AECSSELYTE ASGYISSLEY PRSYPPDLRC NYSIRVERGL TLHLKFLEPF
240 DIDDHQQVHC PYDQLQIYAN GKNIGEFCGK QRPPDLDTSS NAVDLLFFTD ESGDSRGWKL
300 RYTTEIIKCP QPKTLDEFTI IQNLQPQYQF RDYFIATCKQ GYQLIEGNQV LHSFTAVCQD
360 DGTWHRAMPR CKIKDCGQPR NLPNGDFRYT TTMGVNTYKA RIQYYCHEPY YKMQTRAGSR
420 ESEQGVYTCT AQGIWKNEQK GEKIPRCLPV CGKPVNPVEQ RQRIIGGQKA KMGNFPWQVF
480 TNIHGRGGGA LLGDRWILTA AHTLYPKEHE AQSNASLDVF LGHTNVEELM KLGNHPIRRV
540 SVHPDYRQDE SYNFEGDIAL LELENSVTLG PNLLPICLPD NDTFYDLGLM GYVSGFGVME
600 EKIAHDLRFV RLPVANPQAC ENWLRGKNRM DVFSQNMFCA GHPSLKQDAC QGDSGGVFAV
660 RDPNTDRWVA TGIVSWGIGC SRGYGFYTKV LNYVDWIKKE MEEED
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
12089
Leytus S.P.,Kurachi K.,Sakariassen K.S.,Davie E.W.
Nucleotide sequence of the cDNA coding for human complement C1r.
Biochemistry
25
4855-4863
1986
12090
Journet A.,Tosi M.
Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r.
Biochem. J.
240
783-787
1986
12091
Nakagawa M.,Yuasa I.,Irizawa Y.,Umetsu K.
The human complement component C1R gene: the exon-intron structure and the molecular basis of allelic diversity.
Ann. Hum. Genet.
67
207-215
2003
12092
Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.
The full-ORF clone resource of the German cDNA consortium.
BMC Genomics
8
399-399
2007
12093
Scherer S.E.,Muzny D.M.,Buhay C.J.,Chen R.,Cree A.,Ding Y.,Dugan-Rocha S.,Gill R.,Gunaratne P.,Harris R.A.,Hawes A.C.,Hernandez J.,Hodgson A.V.,Hume J.,Jackson A.,Khan Z.M.,Kovar-Smith C.,Lewis L.R.,Lozado R.J.,Metzker M.L.,Milosavljevic A.,Miner G.R.,Montgomery K.T.,Morgan M.B.,Nazareth L.V.,Scott G.,Sodergren E.,Song X.-Z.,Steffen D.,Lovering R.C.,Wheeler D.A.,Worley K.C.,Yuan Y.,Zhang Z.,Adams C.Q.,Ansari-Lari M.A.,Ayele M.,Brown M.J.,Chen G.,Chen Z.,Clerc-Blankenburg K.P.,Davis C.,Delgado O.,Dinh H.H.,Draper H.,Gonzalez-Garay M.L.,Havlak P.,Jackson L.R.,Jacob L.S.,Kelly S.H.,Li L.,Li Z.,Liu J.,Liu W.,Lu J.,Maheshwari M.,Nguyen B.-V.,Okwuonu G.O.,Pasternak S.,Perez L.M.,Plopper F.J.H.,Santibanez J.,Shen H.,Tabor P.E.,Verduzco D.,Waldron L.,Wang Q.,Williams G.A.,Zhang J.,Zhou J.,Allen C.C.,Amin A.G.,Anyalebechi V.,Bailey M.,Barbaria J.A.,Bimage K.E.,Bryant N.P.,Burch P.E.,Burkett C.E.,Burrell K.L.,Calderon E.,Cardenas V.,Carter K.,Casias K.,Cavazos I.,Cavazos S.R.,Ceasar H.,Chacko J.,Chan S.N.,Chavez D.,Christopoulos C.,Chu J.,Cockrell R.,Cox C.D.,Dang M.,Dathorne S.R.,David R.,Davis C.M.,Davy-Carroll L.,Deshazo D.R.,Donlin J.E.,D'Souza L.,Eaves K.A.,Egan A.,Emery-Cohen A.J.,Escotto M.,Flagg N.,Forbes L.D.,Gabisi A.M.,Garza M.,Hamilton C.,Henderson N.,Hernandez O.,Hines S.,Hogues M.E.,Huang M.,Idlebird D.G.,Johnson R.,Jolivet A.,Jones S.,Kagan R.,King L.M.,Leal B.,Lebow H.,Lee S.,LeVan J.M.,Lewis L.C.,London P.,Lorensuhewa L.M.,Loulseged H.,Lovett D.A.,Lucier A.,Lucier R.L.,Ma J.,Madu R.C.,Mapua P.,Martindale A.D.,Martinez E.,Massey E.,Mawhiney S.,Meador M.G.,Mendez S.,Mercado C.,Mercado I.C.,Merritt C.E.,Miner Z.L.,Minja E.,Mitchell T.,Mohabbat F.,Mohabbat K.,Montgomery B.,Moore N.,Morris S.,Munidasa M.,Ngo R.N.,Nguyen N.B.,Nickerson E.,Nwaokelemeh O.O.,Nwokenkwo S.,Obregon M.,Oguh M.,Oragunye N.,Oviedo R.J.,Parish B.J.,Parker D.N.,Parrish J.,Parks K.L.,Paul H.A.,Payton B.A.,Perez A.,Perrin W.,Pickens A.,Primus E.L.,Pu L.-L.,Puazo M.,Quiles M.M.,Quiroz J.B.,Rabata D.,Reeves K.,Ruiz S.J.,Shao H.,Sisson I.,Sonaike T.,Sorelle R.P.,Sutton A.E.,Svatek A.F.,Svetz L.A.,Tamerisa K.S.,Taylor T.R.,Teague B.,Thomas N.,Thorn R.D.,Trejos Z.Y.,Trevino B.K.,Ukegbu O.N.,Urban J.B.,Vasquez L.I.,Vera V.A.,Villasana D.M.,Wang L.,Ward-Moore S.,Warren J.T.,Wei X.,White F.,Williamson A.L.,Wleczyk R.,Wooden H.S.,Wooden S.H.,Yen J.,Yoon L.,Yoon V.,Zorrilla S.E.,Nelson D.,Kucherlapati R.,Weinstock G.,Gibbs R.A.
The finished DNA sequence of human chromosome 12.
Nature
440
346-351
2006
12094
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
12095
Arlaud G.J.,Willis A.C.,Gagnon J.
Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r.
Biochem. J.
241
711-720
1987
12096
Arlaud G.J.,Gagnon J.
Complete amino acid sequence of the catalytic chain of human complement subcomponent C1-r.
Biochemistry
22
1758-1764
1983
12097
Arlaud G.J.,van Dorsselaer A.,Bell A.,Mancini M.,Aude C.,Gagnon J.
Identification of erythro-beta-hydroxyasparagine in the EGF-like domain of human C1r.
FEBS Lett.
222
129-134
1987
12098
Pelloux S.,Thielens N.M.,Hudry-Clergeon G.,Petillot Y.,Filhol O.,Arlaud G.J.
Identification of a cryptic protein kinase CK2 phosphorylation site in human complement protease Clr, and its use to probe intramolecular interaction.
FEBS Lett.
386
15-20
1996
12099
Tosi M.,Duponchel C.,Meo T.,Julier C.
Complete cDNA sequence of human complement Cls and close physical linkage of the homologous genes Cls and Clr.
Biochemistry
26
8516-8524
1987
12100
Liu T.,Qian W.-J.,Gritsenko M.A.,Camp D.G. II,Monroe M.E.,Moore R.J.,Smith R.D.
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
J. Proteome Res.
4
2070-2080
2005
12101
Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
J. Proteome Res.
8
651-661
2009
12102
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
12103
Kapferer-Seebacher I.,Pepin M.,Werner R.,Aitman T.J.,Nordgren A.,Stoiber H.,Thielens N.,Gaboriaud C.,Amberger A.,Schossig A.,Gruber R.,Giunta C.,Bamshad M.,Bjoerck E.,Chen C.,Chitayat D.,Dorschner M.,Schmitt-Egenolf M.,Hale C.J.,Hanna D.,Hennies H.C.,Heiss-Kisielewsky I.,Lindstrand A.,Lundberg P.,Mitchell A.L.,Nickerson D.A.,Reinstein E.,Rohrbach M.,Romani N.,Schmuth M.,Silver R.,Taylan F.,Vandersteen A.,Vandrovcova J.,Weerakkody R.,Yang M.,Pope F.M.,Byers P.H.,Zschocke J.
Periodontal Ehlers-Danlos syndrome is caused by mutations in C1R and C1S, which encode subcomponents C1r and C1s of complement.
Am. J. Hum. Genet.
99
1005-1014
2016
12104
Bersch B.,Hernandez J.-F.,Marion D.,Arlaud G.J.
Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family.
Biochemistry
37
1204-1214
1998
12105
Budayova-Spano M.,Lacroix M.,Thielens N.M.,Arlaud G.J.,Fontecilla-Camps J.-C.,Gaboriaud C.
The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex.
EMBO J.
21
231-239
2002
12106
Budayova-Spano M.,Grabarse W.,Thielens N.M.,Hillen H.,Lacroix M.,Schmidt M.,Fontecilla-Camps J.-C.,Arlaud G.J.,Gaboriaud C.
Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism.
Structure
10
1509-1519
2002
12107
Nothen M.M.,Dewald G.
A common amino acid polymorphism in complement component C1R.
Hum. Mol. Genet.
3
217-217
1994
12108
Su Z.D.,Sun L.,Yu D.X.,Li R.X.,Li H.X.,Yu Z.J.,Sheng Q.H.,Lin X.,Zeng R.,Wu J.R.
Quantitative detection of single amino acid polymorphisms by targeted proteomics.
J. Mol. Cell Biol.
3
309-315
2011