Sequence of CBP_MOUSE

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
histone acetyltransferase
P45481
Mus musculus
2441
265494
Reaction
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine
Sequences with same EC No.
Sequence
show sequence in fasta format
   0 MAENLLDGPP NPKRAKLSSP GFSANDNTDF GSLFDLENDL PDELIPNGEL SLLNSGNLVP
  60 DAASKHKQLS ELLRGGSGSS INPGIGNVSA SSPVQQGLGG QAQGQPNSTN MASLGAMGKS
 120 PLNQGDSSTP NLPKQAASTS GPTPPASQAL NPQAQKQVGL VTSSPATSQT GPGICMNANF
 180 NQTHPGLLNS NSGHSLMNQA QQGQAQVMNG SLGAAGRGRG AGMPYPAPAM QGATSSVLAE
 240 TLTQVSPQMA GHAGLNTAQA GGMTKMGMTG TTSPFGQPFS QTGGQQMGAT GVNPQLASKQ
 300 SMVNSLPAFP TDIKNTSVTT VPNMSQLQTS VGIVPTQAIA TGPTADPEKR KLIQQQLVLL
 360 LHAHKCQRRE QANGEVRACS LPHCRTMKNV LNHMTHCQAG KACQVAHCAS SRQIISHWKN
 420 CTRHDCPVCL PLKNASDKRN QQTILGSPAS GIQNTIGSVG AGQQNATSLS NPNPIDPSSM
 480 QRAYAALGLP YMNQPQTQLQ PQVPGQQPAQ PPAHQQMRTL NALGNNPMSI PAGGITTDQQ
 540 PPNLISESAL PTSLGATNPL MNDGSNSGNI GSLSTIPTAA PPSSTGVRKG WHEHVTQDLR
 600 SHLVHKLVQA IFPTPDPAAL KDRRMENLVA YAKKVEGDMY ESANSRDEYY HLLAEKIYKI
 660 QKELEEKRRS RLHKQGILGN QPALPASGAQ PPVIPPAQSV RPPNGPLPLP VNRMQVSQGM
 720 NSFNPMSLGN VQLPQAPMGP RAASPMNHSV QMNSMASVPG MAISPSRMPQ PPNMMGTHAN
 780 NIMAQAPTQN QFLPQNQFPS SSGAMSVNSV GMGQPAAQAG VSQGQVPGAA LPNPLNMLAP
 840 QASQLPCPPV TQSPLHPTPP PASTAAGMPS LQHPTAPGMT PPQPAAPTQP STPVSSGQTP
 900 TPTPGSVPSA AQTQSTPTVQ AAAQAQVTPQ PQTPVQPPSV ATPQSSQQQP TPVHTQPPGT
 960 PLSQAAASID NRVPTPSSVT SAETSSQQPG PDVPMLEMKT EVQTDDAEPE PTESKGEPRS
1020 EMMEEDLQGS SQVKEETDTT EQKSEPMEVE EKKPEVKVEA KEEEENSSND TASQSTSPSQ
1080 PRKKIFKPEE LRQALMPTLE ALYRQDPESL PFRQPVDPQL LGIPDYFDIV KNPMDLSTIK
1140 RKLDTGQYQE PWQYVDDVWL MFNNAWLYNR KTSRVYKFCS KLAEVFEQEI DPVMQSLGYC
1200 CGRKYEFSPQ TLCCYGKQLC TIPRDAAYYS YQNRYHFCEK CFTEIQGENV TLGDDPSQPQ
1260 TTISKDQFEK KKNDTLDPEP FVDCKECGRK MHQICVLHYD IIWPSGFVCD NCLKKTGRPR
1320 KENKFSAKRL QTTRLGNHLE DRVNKFLRRQ NHPEAGEVFV RVVASSDKTV EVKPGMKSRF
1380 VDSGEMSESF PYRTKALFAF EEIDGVDVCF FGMHVQNTAL IAPHQIQGRV YISYLDSIHF
1440 FRPRCLRTAV YHEILIGYLE YVKKLGYVTG HIWACPPSEG DDYIFHCHPP DQKIPKPKRL
1500 QEWYKKMLDK AFAERIINDY KDIFKQANED RLTSAKELPY FEGDFWPNVL EESIKELEQE
1560 EEERKKEEST AASETPEGSQ GDSKNAKKKN NKKTNKNKSS ISRANKKKPS MPNVSNDLSQ
1620 KLYATMEKHK EVFFVIHLHA GPVISTQPPI VDPDPLLSCD LMDGRDAFLT LARDKHWEFS
1680 SLRRSKWSTL CMLVELHTQG QDRFVYTCNE CKHHVETRWH CTVCEDYDLC INCYNTKSHT
1740 HKMVKWGLGL DDEGSSQGEP QSKSPQESRR LSIQRCIQSL VHACQCRNAN CSLPSCQKMK
1800 RVVQHTKGCK RKTNGGCPVC KQLIALCCYH AKHCQENKCP VPFCLNIKHK LRQQQIQHRL
1860 QQAQLMRRRM ATMNTRNVPQ QSLPSPTSAP PGTPTQQPST PQTPQPPAQP QPSPVNMSPA
1920 GFPNVARTQP PTIVSAGKPT NQVPAPPPPA QPPPAAVEAA RQIEREAQQQ QHLYRANINN
1980 GMPPGRAGMG TPGSQMTPVG LNVPRPNQVS GPVMSSMPPG QWQQAPIPQQ QPMPGMPRPV
2040 MSMQAQAAVA GPRMPNVQPP RSISPSALQD LLRTLKSPSS PQQQQQVLNI LKSNPQLMAA
2100 FIKQRTAKYV ANQPGMQPQP GLQSQPGMQP QPGMHQQPSL QNLNAMQAGV PRPGVPPPQP
2160 AMGGLNPQGQ ALNIMNPGHN PNMTNMNPQY REMVRRQLLQ HQQQQQQQQQ QQQQQQNSAS
2220 LAGGMAGHSQ FQQPQGPGGY APAMQQQRMQ QHLPIQGSSM GQMAAPMGQL GQMGQPGLGA
2280 DSTPNIQQAL QQRILQQQQM KQQIGSPGQP NPMSPQQHML SGQPQASHLP GQQIATSLSN
2340 QVRSPAPVQS PRPQSQPPHS SPSPRIQPQP SPHHVSPQTG SPHPGLAVTM ASSMDQGHLG
2400 NPEQSAMLPQ LNTPNRSALS SELSLVGDTT GDTLEKFVEG L
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
135004
Chrivia J.C.,Kwok R.P.S.,Lamb N.,Hagiwara M.,Montminy M.R.,Goodman R.H.
Phosphorylated CREB binds specifically to the nuclear protein CBP.
Nature
365
855-859
1993
135005
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
0-0
2009
135006
Kamei Y.,Xu L.,Heinzel T.,Torchia J.,Kurokawa R.,Gloss B.,Lin S.-C.,Heyman R.A.,Rose D.W.,Glass C.K.,Rosenfeld M.G.
A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.
Cell
85
403-414
1996
135007
Parker D.,Ferreri K.,Nakajima T.,LaMorte V.J.,Evans R.,Koerber S.C.,Hoeger C.,Montminy M.R.
Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism.
Mol. Cell. Biol.
16
694-703
1996
135008
Torchia J.,Rose D.W.,Inostroza J.,Kamei Y.,Westin S.,Glass C.K.,Rosenfeld M.G.
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.
Nature
387
677-684
1997
135009
Hung H.L.,Lau J.,Kim A.Y.,Weiss M.J.,Blobel G.A.
CREB-Binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites.
Mol. Cell. Biol.
19
3496-3505
1999
135010
Yahata T.,de Caestecker M.P.,Lechleider R.J.,Andriole S.,Roberts A.B.,Isselbacher K.J.,Shioda T.
The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors.
J. Biol. Chem.
275
8825-8834
2000
135011
Xu W.,Chen H.,Du K.,Asahara H.,Tini M.,Emerson B.M.,Montminy M.,Evans R.M.
A transcriptional switch mediated by cofactor methylation.
Science
294
2507-2511
2001
135012
Yahata T.,Takedatsu H.,Dunwoodie S.L.,Braganca J.,Swingler T.,Withington S.L.,Hur J.,Coser K.R.,Isselbacher K.J.,Bhattacharya S.,Shioda T.
Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells.
Genomics
80
601-613
2002
135013
Chen Q.,Dowhan D.H.,Liang D.,Moore D.D.,Overbeek P.A.
CREB-binding protein/p300 co-activation of crystallin gene expression.
J. Biol. Chem.
277
24081-24089
2002
135014
Rossow K.L.,Janknecht R.
Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300.
Oncogene
22
151-156
2003
135015
Daitoku H.,Hatta M.,Matsuzaki H.,Aratani S.,Ohshima T.,Miyagishi M.,Nakajima T.,Fukamizu A.
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
Proc. Natl. Acad. Sci. U.S.A.
101
10042-10047
2004
135016
Kuo H.-Y.,Chang C.-C.,Jeng J.-C.,Hu H.-M.,Lin D.-Y.,Maul G.G.,Kwok R.P.S.,Shih H.-M.
SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx.
Proc. Natl. Acad. Sci. U.S.A.
102
16973-16978
2005
135017
Shin S.,Janknecht R.
Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF.
J. Cell. Biochem.
101
1252-1265
2007
135018
Cho G.,Lim Y.,Zand D.,Golden J.A.
Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling.
Mol. Cell. Biol.
28
1565-1572
2008
135019
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
135020
Park J.,Chen Y.,Tishkoff D.X.,Peng C.,Tan M.,Dai L.,Xie Z.,Zhang Y.,Zwaans B.M.,Skinner M.E.,Lombard D.B.,Zhao Y.
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
Mol. Cell
50
919-930
2013
135021
Anafi R.C.,Lee Y.,Sato T.K.,Venkataraman A.,Ramanathan C.,Kavakli I.H.,Hughes M.E.,Baggs J.E.,Growe J.,Liu A.C.,Kim J.,Hogenesch J.B.
Machine learning helps identify CHRONO as a circadian clock component.
PLoS Biol.
12
0-0
2014
135022
De Guzman R.N.,Martinez-Yamout M.A.,Dyson H.J.,Wright P.E.
Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites.
J. Biol. Chem.
279
3042-3049
2004