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Sequence of ABD12_MOUSE

EC Number:3.1.1.23

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
acylglycerol lipase
Q99LR1
Mus musculus
398
45270
Reaction
CnHmCO-C3O3H7 + H2O = CnHmCO2H + glycerol
Other sequences found for EC No. 3.1.1.23

General information:

Sequence
show sequence in fasta format
  0 MRKRTEPVTL EHERCAASGS SSSGSAAAAL DADCSLKQNL RLAGKGTAEP HSASDAGMKR
 60 ALGRRKSLWF RLRKILLCVL GFYIAIPFLV KLCPGIQAKL IFLNFVRVPY FIDLKKPQDQ
120 GLNHTCNYYL QPEDDVTIGV WHTIPSVWWK NAQGKDQMWY EDALASNHAI ILYLHGNAGT
180 RGGDHRVELY KVLSSLGYHV VTFDYRGWGD SVGTPSERGM TYDALHVFDW IKARSGDNPV
240 YIWGHSLGTG VATNLVRRLC ERETPPDALI LESPFTNIRE EAKSHPFSVI YRYFPGFDWF
300 FLDPITSSGI KFANDENMKH ISCPLLILHA EDDPVVPFHL GRKLYNIAAP SRSFRDFKVQ
360 FIPFHSDLGY RHKYIYKSPE LPRILREFLG KSEPERQH
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
127742
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
0-0
2009
127744
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
127745
Blankman J.L.,Simon G.M.,Cravatt B.F.
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol.
Chem. Biol.
14
1347-1356
2007
127746
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
127747
Marrs W.R.,Blankman J.L.,Horne E.A.,Thomazeau A.,Lin Y.H.,Coy J.,Bodor A.L.,Muccioli G.G.,Hu S.S.,Woodruff G.,Fung S.,Lafourcade M.,Alexander J.P.,Long J.Z.,Li W.,Xu C.,Moller T.,Mackie K.,Manzoni O.J.,Cravatt B.F.,Stella N.
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors.
Nat. Neurosci.
13
951-957
2010
127748
Blankman J.L.,Long J.Z.,Trauger S.A.,Siuzdak G.,Cravatt B.F.
ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC.
Proc. Natl. Acad. Sci. U.S.A.
110
1500-1505
2013
127749
Kamat S.S.,Camara K.,Parsons W.H.,Chen D.H.,Dix M.M.,Bird T.D.,Howell A.R.,Cravatt B.F.
Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.
Nat. Chem. Biol.
11
164-171
2015
127750
Joshi A.,Shaikh M.,Singh S.,Rajendran A.,Mhetre A.,Kamat S.S.
Biochemical characterization of the PHARC-associated serine hydrolase ABHD12 reveals its preference for very-long-chain lipids.
J. Biol. Chem.
293
16953-16963
2018
127751
Ogasawara D.,Ichu T.A.,Vartabedian V.F.,Benthuysen J.,Jing H.,Reed A.,Ulanovskaya O.A.,Hulce J.J.,Roberts A.,Brown S.,Rosen H.,Teijaro J.R.,Cravatt B.F.
Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo.
Nat. Chem. Biol.
14
1099-1108
2018
127752
Kelkar D.S.,Ravikumar G.,Mehendale N.,Singh S.,Joshi A.,Sharma A.K.,Mhetre A.,Rajendran A.,Chakrapani H.,Kamat S.S.
A chemical-genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase.
Nat. Chem. Biol.
15
169-178
2019