Sequence of ABCAC_MOUSE
EC Number:7.6.2.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + H2O + phospholipid [side 1] = ADP + phosphate + phospholipid [side 2]
Other sequences found for EC No. 7.6.2.1
General information:
Sequence
0 MASQFHQLRI LVWKNWLGVK RQPLWTLVLI LWPVIIFIIL AITRTKFPPT AKPTCYLAPR
60 NLPSAGFFPF LQTLLCDTDS KCKDTPYGPR DLLRRKGIDG PLFKESEILK KPSNPKRDSN
120 LSLRSTQVPE RSHTSLATVP PRPSYDLEGT GTENFNGSQL LTRILGLEKL LKQNSTPEDI
180 RRELCESYPG YTADYAFSWV TLGKNVFNKF CLSNMTLLES SLQELKYQVS QMSSDPDNQK
240 RVFRGLVQVL SFFSQVQQQR EVWQLLSSLP DVFQNGTSLS SLFGVLQKAN RVLLVVQKVY
300 PRVQTDEGFS TLQKSVKHLL NTLDSPMQGD NSTHAWSDDD EQTLSPSSLA AQLLILENFE
360 DAILNISSNS PYSPYLACVR NMTDNLAKGS PDNLKLLQST IHFRKSFLQN GSSEDSFPPF
420 LEILKSKLSQ LRNLTELLCE SETFSSIKKS CQFSNMSFER LCEDHAFHVQ LIEAAELGTD
480 LTTGLLYHDN IISAKLRGLL TGDPSKINLN VDWLLEQALQ MNYLENITRL IPTVEAMLHV
540 NTSADASEKP GQLREMFKNI DLLKEDLRAI GMSNTSIDKL LAIPIPDNRA EIISRVFWLH
600 SCDTNVTNPK LEDAMKEFCK LPLPERSHQS YLIGLTLLHY LDIYNFTYKV FFPRKDQKPM
660 ERMMELFIKL REILNQLASG THPLLDKMRS LRQMHLPRSV PLTQAMYRNT RMNSPAGSFS
720 TISQALCSQG ITTEYLTAML PSSQKPKGNH TKDFLTYKLT KEEIASKYGI PLNATPFCFS
780 LYKDIINMPA GPVIWAFLKP MLLGKILYSP YNPTTKAIME KSNVTLRQLA ELREKSQEWM
840 DKSPIFMNSF HLLNQTIPML QNTLRNPFVQ VFVKFSVGLD AVELLKQIDD LDVLRLKLVN
900 NIDIIDQLNT LSSLTVNISS CVLYDRIQAS DTVEEMETVA EQLYKSNELF GSVIFKLPSN
960 GSLHRGFDPE KVSLPPIVRY TIRMSLKTAQ TTRSIRTKIW APGPHNSPSH NQIYGRAFIY
1020 LQDSIERAII ELQTGRNSQE VAVQVQAVPY PCFMKDNFLT SVSYSLPIVL MVAWVVFIAA
1080 FVKKLVYEKD LRLHEYMKMM GVNSCSHFFA WLIESIGFLL VTIAILIVIL KFGNILPKTN
1140 GFILFLYFSD YSFSVIAMSY LISVFFNNTN IAALIGSLIY VIAFFPFIVL VTVEDELSYV
1200 IKVFMSLLSP TAFSYASQYI ARYEEQGVGL QWENMYKSPV QDDTTSFGWL CCLILADSFI
1260 YFFIAWYVRN VFPGTYGMAA PWYFPILPSY WKERFGCAEV KHEKSNGLMF TNIMMQNTNP
1320 SASKTSPDCA FPSNIEPEPK DLQVGVALHG VTKIYGSKTA VENLNLNFYE GHITSLLGPN
1380 GAGKTTTISM LTGLFGATAG TIFVYGKDIK TDLNTVRKNM GVCMQHDVLF SYLTTKEHLL
1440 LYGSIKVPHW TKTQLHEEVK RTLKDTGLYS HRHKRVGTLS GGMKRKLSIS IALIGGSRVV
1500 ILDEPSTGVD PCSRRSIWDV ISKNKTARTI ILSTHHLDEA EVLSDRIAFL EQGGLRCCGS
1560 PFYLKEAFGD GYHLTLTKKK SPNLDTNAIC DTVAVTAMIQ SHLPEAYLKE DIGGELVYVL
1620 PPFSTKVSGA YLSLLRALDK GMGKLNIGCY GISDTTVEEV FLNLTKDSQK SSNMSLEHLT
1680 QRKVGNPSAN GTSTPDDLSV SSSNFTDRDD KVLTRSEKLE GFGLLLKKIM AILIKRFHHT
1740 RRNWKGLIAQ VILPIVFVAT AMGLGTLRDS SNSYPEIMIS PSIYGTSEQT AFYANFDPST
1800 SGLVSALWNF PGIDNVCLNT SDLQCLKKDD LGKWNTSGEA IDNFGVCSCS DNVQECPKFN
1860 YHPPHRRTYS SQVIYNLTGK HMENYLITTA NHFVQKRYGG WSFGMKLTND LRFDVTAVPD
1920 NRTLAKVWYD PEGYHSLPAY LNSLNNFLLR VNMSEYDAAR HGIIMYSHPY PGVQDQEQAT
1980 ISSLIDILVA LSILMGYSVT TASFVTYIVR EHQTKAKQLQ HISGIGVTCY WVTNFIYDMV
2040 FYLVPVAFSI GVIAIFKLPA FYSGNNLGAV SLLLLLFGYA TFSWMYLLAG LFHETGMAFI
2100 TYVCVNLFFG INSIVSLSVV YFLSKEKPND PTLELISETL KRIFLIFPQF CFGYGLIELS
2160 QQQAVLDFLK AYGVEYPSET FEMDKLGAMF VALVSQGTMF FLLRLLINEW LIKKLRLFFR
2220 KFTSSPIMET VDEDEDVRAE RFRVESGAAE FDLVQLHRLT KTYQLIHKKI IAVNNISLGI
2280 PAGECFGLLG VNGAGKTTIF KMLTGDIIPS SGNILIRNKS GSLGHVDSHS SLVGYCPQED
2340 ALDDLVTVEE HLYFYARVHG IPEKDIKDTV HKLLRRLHLM AYKDRSTSMC SYGTKRKLST
2400 ALALIGKPSI LLLDEPSSGM DPKSKRHLWR IISEEVQNKC SVILTSHSME ECEALCTRLA
2460 IMVNGRFQCI GSLQHIKSRF GRGFTVKVHL KNNKVSMETL TKFMQLHFPK TYLKDQHLSM
2520 LEYHVPVTAG GVANIFDLLE TNKTALNITN FLVSQTTLEE VFINFAKDQK SYENVDTSSQ
2580 GSTISVDSQE DQLDS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
127672
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
0-0
2009
127673
Yanagi T.,Akiyama M.,Nishihara H.,Sakai K.,Nishie W.,Tanaka S.,Shimizu H.
Harlequin ichthyosis model mouse reveals alveolar collapse and severe fetal skin barrier defects.
Hum. Mol. Genet.
17
3075-3083
2008
127674
Zuo Y.,Zhuang D.Z.,Han R.,Isaac G.,Tobin J.J.,McKee M.,Welti R.,Brissette J.L.,Fitzgerald M.L.,Freeman M.W.
ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters.
J. Biol. Chem.
283
36624-36635
2008
127675
Smyth I.,Hacking D.F.,Hilton A.A.,Mukhamedova N.,Meikle P.J.,Ellis S.,Satterley K.,Slattery K.,Collinge J.E.,de Graaf C.A.,Bahlo M.,Sviridov D.,Kile B.T.,Hilton D.J.
A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis.
PLoS Genet.
4
0-0
2008
127676
Yanagi T.,Akiyama M.,Nishihara H.,Ishikawa J.,Sakai K.,Miyamura Y.,Naoe A.,Kitahara T.,Tanaka S.,Shimizu H.
Self-improvement of keratinocyte differentiation defects during skin maturation in ABCA12-deficient harlequin ichthyosis model mice.
Am. J. Pathol.
177
106-118
2010
127677
Fu Y.,Mukhamedova N.,Ip S.,D'Souza W.,Henley K.J.,DiTommaso T.,Kesani R.,Ditiatkovski M.,Jones L.,Lane R.M.,Jennings G.,Smyth I.M.,Kile B.T.,Sviridov D.
ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis.
Cell Metab.
18
225-238
2013
127678
Haller J.F.,Cavallaro P.,Hernandez N.J.,Dolat L.,Soscia S.J.,Welti R.,Grabowski G.A.,Fitzgerald M.L.,Freeman M.W.
Endogenous beta-glucocerebrosidase activity in Abca12-/- epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.
J. Lipid Res.
55
493-503
2014
127679
Zhang L.,Ferreyros M.,Feng W.,Hupe M.,Crumrine D.A.,Chen J.,Elias P.M.,Holleran W.M.,Niswander L.,Hohl D.,Williams T.,Torchia E.C.,Roop D.R.
Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis.
PLoS ONE
11
0-0
2016
127680
Ursino G.M.,Fu Y.,Cottle D.L.,Mukhamedova N.,Jones L.K.,Low H.,Tham M.S.,Gan W.J.,Mellett N.A.,Das P.P.,Weir J.M.,Ditiatkovski M.,Fynch S.,Thorn P.,Thomas H.E.,Meikle P.J.,Parkington H.C.,Smyth I.M.,Sviridov D.
ABCA12 regulates insulin secretion from beta-cells.
EMBO Rep.
21
0-0
2020
127681
Teramura T.,Nomura T.
Acute skin barrier disruption alters the secretion of lamellar bodies via the multilayered expression of ABCA12.
J. Dermatol. Sci.
100
50-57
2020
