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Sequence of AT2B1_HUMAN

EC Number:3.6.3.8

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Ca2+-transporting ATPase
P20020
Homo sapiens
1220
134685
Reaction

General information:

Sequence
show sequence in fasta format
   0 MGDMANNSVA YSGVKNSLKE ANHDGDFGIT LAELRALMEL RSTDALRKIQ ESYGDVYGIC
  60 TKLKTSPNEG LSGNPADLER REAVFGKNFI PPKKPKTFLQ LVWEALQDVT LIILEIAAIV
 120 SLGLSFYQPP EGDNALCGEV SVGEEEGEGE TGWIEGAAIL LSVVCVVLVT AFNDWSKEKQ
 180 FRGLQSRIEQ EQKFTVIRGG QVIQIPVADI TVGDIAQVKY GDLLPADGIL IQGNDLKIDE
 240 SSLTGESDHV KKSLDKDPLL LSGTHVMEGS GRMVVTAVGV NSQTGIIFTL LGAGGEEEEK
 300 KDEKKKEKKN KKQDGAIENR NKAKAQDGAA MEMQPLKSEE GGDGDEKDKK KANLPKKEKS
 360 VLQGKLTKLA VQIGKAGLLM SAITVIILVL YFVIDTFWVQ KRPWLAECTP IYIQYFVKFF
 420 IIGVTVLVVA VPEGLPLAVT ISLAYSVKKM MKDNNLVRHL DACETMGNAT AICSDKTGTL
 480 TMNRMTVVQA YINEKHYKKV PEPEAIPPNI LSYLVTGISV NCAYTSKILP PEKEGGLPRH
 540 VGNKTECALL GLLLDLKRDY QDVRNEIPEE ALYKVYTFNS VRKSMSTVLK NSDGSYRIFS
 600 KGASEIILKK CFKILSANGE AKVFRPRDRD DIVKTVIEPM ASEGLRTICL AFRDFPAGEP
 660 EPEWDNENDI VTGLTCIAVV GIEDPVRPEV PDAIKKCQRA GITVRMVTGD NINTARAIAT
 720 KCGILHPGED FLCLEGKDFN RRIRNEKGEI EQERIDKIWP KLRVLARSSP TDKHTLVKGI
 780 IDSTVSDQRQ VVAVTGDGTN DGPALKKADV GFAMGIAGTD VAKEASDIIL TDDNFTSIVK
 840 AVMWGRNVYD SISKFLQFQL TVNVVAVIVA FTGACITQDS PLKAVQMLWV NLIMDTLASL
 900 ALATEPPTES LLLRKPYGRN KPLISRTMMK NILGHAFYQL VVVFTLLFAG EKFFDIDSGR
 960 NAPLHAPPSE HYTIVFNTFV LMQLFNEINA RKIHGERNVF EGIFNNAIFC TIVLGTFVVQ
1020 IIIVQFGGKP FSCSELSIEQ WLWSIFLGMG TLLWGQLIST IPTSRLKFLK EAGHGTQKEE
1080 IPEEELAEDV EEIDHAEREL RRGQILWFRG LNRIQTQIRV VNAFRSSLYE GLEKPESRSS
1140 IHNFMTHPEF RIEDSEPHIP LIDDTDAEDD APTKRNSSPP PSPNKNNNAV DSGIHLTIEM
1200 NKSATSSSPG SPLHSLETSL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
452082
Verma A.K.,Filoteo A.G.,Stanford D.R.,Wieben E.D.,Penniston J.T.,Strehler E.E.,Fischer R.,Heim R.,Vogel G.,Mathews S.,Strehler-Page M.-A.,James P.,Vorherr T.E.,Krebs J.,Carafoli E.
Complete primary structure of a human plasma membrane Ca2+ pump.
J. Biol. Chem.
263
14152-14159
1988
452083
Kumar R.,Haugen J.D.,Penniston J.T.
Molecular cloning of a plasma membrane calcium pump from human osteoblasts.
J. Bone Miner. Res.
8
505-513
1993
452084
Hilfiker H.,Strehler-Page M.-A.,Stauffer T.P.,Carafoli E.,Strehler E.E.
Structure of the gene encoding the human plasma membrane calcium pump isoform 1.
J. Biol. Chem.
268
19717-19725
1993
452086
Strehler E.E.,Strehler-Page M.-A.,Vogel G.,Carafoli E.
mRNAs for plasma membrane calcium pump isoforms differing in their regulatory domain are generated by alternative splicing that involves two internal donor sites in a single exon.
Proc. Natl. Acad. Sci. U.S.A.
86
6908-6912
1989
452087
Kessler F.,Falchetto R.,Heim R.,Meili R.,Vorherr T.E.,Strehler E.E.,Carafoli E.
Study of calmodulin binding to the alternatively spliced C-terminal domain of the plasma membrane Ca2+ pump.
Biochemistry
31
11785-11792
1992
452088
Stauffer T.P.,Hilfiker H.,Carafoli E.,Strehler E.E.
Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.
J. Biol. Chem.
268
25993-26003
1993
452089
Stauffer T.P.,Hilfiker H.,Carafoli E.,Strehler E.E.
J. Biol. Chem.
269
32022-32022
1994
452090
Howard A.,Legon S.,Walters J.R.
Human and rat intestinal plasma membrane calcium pump isoforms.
Am. J. Physiol.
265
G917-G925
1993
452091
James P.H.,Pruschy M.,Vorherr T.E.,Penniston J.T.,Carafoli E.
Primary structure of the cAMP-dependent phosphorylation site of the plasma membrane calcium pump.
Biochemistry
28
4253-4258
1989
452092
Wang K.K.W.,Wright L.C.,Machan C.L.,Allen B.G.,Conigrave A.D.,Roufogalis B.D.
Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes.
J. Biol. Chem.
266
9078-9085
1991
452093
Goellner G.M.,DeMarco S.J.,Strehler E.E.
Characterization of PISP, a novel single-PDZ protein that binds to all plasma membrane Ca2+-ATPase b-splice variants.
Ann. N. Y. Acad. Sci.
986
461-471
2003
452094
Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Cell
127
635-648
2006
452095
Linde C.I.,Di Leva F.,Domi T.,Tosatto S.C.,Brini M.,Carafoli E.
Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump.
Cell Calcium
43
550-561
2008
452096
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
452097
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
RA3-RA3
2010
452098
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
452099
Yang H.,Choi K.C.,Hyun S.H.,Jeung E.B.
Coexpression and estrogen-mediated regulation of TRPV6 and PMCA1 in the human endometrium during the menstrual cycle.
Mol. Reprod. Dev.
78
274-282
2011
452100
Krapivinsky G.,Krapivinsky L.,Stotz S.C.,Manasian Y.,Clapham D.E.
POST, partner of stromal interaction molecule 1 (STIM1), targets STIM1 to multiple transporters.
Proc. Natl. Acad. Sci. U.S.A.
108
19234-19239
2011
452101
Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
Sci. Signal.
4
RS3-RS3
2011
452102
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
452103
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
452104
Long Y.,Xia J.Y.,Chen S.W.,Gao C.L.,Liang G.N.,He X.M.,Wu J.,Jiang C.X.,Liu X.,Huang W.,Wan Q.,Xu Y.
ATP2B1 gene Silencing Increases Insulin Sensitivity through Facilitating Akt Activation via the Ca2+/calmodulin Signaling Pathway and Ca2+-associated eNOS Activation in Endothelial Cells.
Int. J. Biol. Sci.
13
1203-1212
2017
452105
Gong D.,Chi X.,Ren K.,Huang G.,Zhou G.,Yan N.,Lei J.,Zhou Q.
Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin.
Nat. Commun.
9
3623-3623
2018
452106
Benkwitz C.,Kubsisch C.,Kraft K.,Neyses L.
Investigation of the Met-267 Arg exchange in isoform 1 of the human plasma membrane calcium pump in patients with essential hypertension by the amplification-created restriction site technique.
J. Mol. Med.
75
62-66
1997
452107
Rahimi M.J.,Urban N.,Wegler M.,Sticht H.,Schaefer M.,Popp B.,Gaunitz F.,Morleo M.,Nigro V.,Maitz S.,Mancini G.M.S.,Ruivenkamp C.,Suk E.K.,Bartolomaeus T.,Merkenschlager A.,Koboldt D.,Bartholomew D.,Stegmann A.P.A.,Sinnema M.,Duynisveld I.,Salvarinova R.,Race S.,de Vries B.B.A.,Trimouille A.,Naudion S.,Marom D.,Hamiel U.,Henig N.,Demurger F.,Rahner N.,Bartels E.,Hamm J.A.,Putnam A.M.,Person R.,Abou Jamra R.,Oppermann H.
De novo variants in ATP2B1 lead to neurodevelopmental delay.
Am. J. Hum. Genet.
109
944-952
2022