Sequence of UFC1_HUMAN

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Zhang Q.-H.,Ye M.,Wu X.-Y.,Ren S.-X.,Zhao M.,Zhao C.-J.,Fu G.,Shen Y.,Fan H.-Y.,Lu G.,Zhong M.,Xu X.-R.,Han Z.-G.,Zhang J.-W.,Tao J.,Huang Q.-H.,Zhou J.,Hu G.-X.,Gu J.,Chen S.-J.,Chen Z.

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Complete sequencing and characterization of 21,243 full-length human cDNAs.

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The DNA sequence and biological annotation of human chromosome 1.

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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

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Tatsumi K.,Sou Y.S.,Tada N.,Nakamura E.,Iemura S.,Natsume T.,Kang S.H.,Chung C.H.,Kasahara M.,Kominami E.,Yamamoto M.,Tanaka K.,Komatsu M.

A novel type of E3 ligase for the Ufm1 conjugation system.

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Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

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Liu Y.F.,Sowell S.M.,Luo Y.,Chaubey A.,Cameron R.S.,Kim H.G.,Srivastava A.K.

Autism and intellectual disability-associated KIRREL3 interacts with neuronal proteins MAP1B and MYO16 with potential roles in neurodevelopment.

PLoS ONE

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Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.

N-terminome analysis of the human mitochondrial proteome.

Proteomics

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Oweis W.,Padala P.,Hassouna F.,Cohen-Kfir E.,Gibbs D.R.,Todd E.A.,Berndsen C.E.,Wiener R.

Trans-binding mechanism of ubiquitin-like protein activation revealed by a UBA5-UFM1 Complex.

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DeJesus R.,Moretti F.,McAllister G.,Wang Z.,Bergman P.,Liu S.,Frias E.,Alford J.,Reece-Hoyes J.S.,Lindeman A.,Kelliher J.,Russ C.,Knehr J.,Carbone W.,Beibel M.,Roma G.,Ng A.,Tallarico J.A.,Porter J.A.,Xavier R.J.,Mickanin C.,Murphy L.O.,Hoffman G.R.,Nyfeler B.

Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62.

Elife

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Nahorski M.S.,Maddirevula S.,Ishimura R.,Alsahli S.,Brady A.F.,Begemann A.,Mizushima T.,Guzman-Vega F.J.,Obata M.,Ichimura Y.,Alsaif H.S.,Anazi S.,Ibrahim N.,Abdulwahab F.,Hashem M.,Monies D.,Abouelhoda M.,Meyer B.F.,Alfadhel M.,Eyaid W.,Zweier M.,Steindl K.,Rauch A.,Arold S.T.,Woods C.G.,Komatsu M.,Alkuraya F.S.

Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.

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Qin B.,Yu J.,Nowsheen S.,Wang M.,Tu X.,Liu T.,Li H.,Wang L.,Lou Z.

UFL1 promotes histone H4 ufmylation and ATM activation.

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Walczak C.P.,Leto D.E.,Zhang L.,Riepe C.,Muller R.Y.,DaRosa P.A.,Ingolia N.T.,Elias J.E.,Kopito R.R.

Ribosomal protein RPL26 is the principal target of UFMylation.

Proc. Natl. Acad. Sci. U.S.A.

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Liang J.R.,Lingeman E.,Luong T.,Ahmed S.,Muhar M.,Nguyen T.,Olzmann J.A.,Corn J.E.

A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation.

Cell

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Millrine D.,Cummings T.,Matthews S.P.,Peter J.J.,Magnussen H.M.,Lange S.M.,Macartney T.,Lamoliatte F.,Knebel A.,Kulathu Y.

Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation.

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Peter J.J.,Magnussen H.M.,DaRosa P.A.,Millrine D.,Matthews S.P.,Lamoliatte F.,Sundaramoorthy R.,Kopito R.R.,Kulathu Y.

A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation.

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Snider D.L.,Park M.,Murphy K.A.,Beachboard D.C.,Horner S.M.

Signaling from the RNA sensor RIG-I is regulated by ufmylation.

Proc. Natl. Acad. Sci. U.S.A.

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Banerjee S.,Varga J.K.,Kumar M.,Zoltsman G.,Rotem-Bamberger S.,Cohen-Kfir E.,Isupov M.N.,Rosenzweig R.,Schueler-Furman O.,Wiener R.

Structural study of UFL1-UFC1 interaction uncovers the role of UFL1 N-terminal helix in ufmylation.

EMBO Rep.

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Scavone F.,Gumbin S.C.,Da Rosa P.A.,Kopito R.R.

RPL26/uL24 UFMylation is essential for ribosome-associated quality control at the endoplasmic reticulum.

Proc. Natl. Acad. Sci. U.S.A.

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1310372

Liu G.,Aramini J.,Atreya H.S.,Eletsky A.,Xiao R.,Acton T.,Ma L.,Montelione G.T.,Szyperski T.

GFT NMR based resonance assignment for the 21 kDa human protein UFC1.

J. Biomol. NMR

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2005

1310373

Mizushima T.,Tatsumi K.,Ozaki Y.,Kawakami T.,Suzuki A.,Ogasahara K.,Komatsu M.,Kominami E.,Tanaka K.,Yamane T.

Crystal structure of Ufc1, the Ufm1-conjugating enzyme.

Biochem. Biophys. Res. Commun.

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Liu G.,Forouhar F.,Eletsky A.,Atreya H.S.,Aramini J.M.,Xiao R.,Huang Y.J.,Abashidze M.,Seetharaman J.,Liu J.,Rost B.,Acton T.,Montelione G.T.,Hunt J.F.,Szyperski T.

NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway.

J. Struct. Funct. Genomics

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2009

1310375

Wesch N.,Loehr F.,Rogova N.,Doetsch V.,Rogov V.V.

A concerted action of UBA5 C-terminal unstructured regions is important for transfer of activated UFM1 to UFC1.

Int. J. Mol. Sci.

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1310376

Kumar M.,Padala P.,Fahoum J.,Hassouna F.,Tsaban T.,Zoltsman G.,Banerjee S.,Cohen-Kfir E.,Dessau M.,Rosenzweig R.,Isupov M.N.,Schueler-Furman O.,Wiener R.

Structural basis for UFM1 transfer from UBA5 to UFC1.

Nat. Commun.

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2021

1310377

Makhlouf L.,Peter J.J.,Magnussen H.M.,Thakur R.,Millrine D.,Minshull T.C.,Harrison G.,Varghese J.,Lamoliatte F.,Foglizzo M.,Macartney T.,Calabrese A.N.,Zeqiraj E.,Kulathu Y.

The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.

Nature

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437-444

2024