Sequence of UB2D2_HUMAN

ubiquitin-protein ligase

P62837

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16735

614382

Jensen J.P.,Bates P.W.,Yang M.,Vierstra R.D.,Weissman A.M.

Identification of a family of closely related human ubiquitin conjugating enzymes.

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614383

Rolfe M.,Beer-Romero P.,Glass S.,Eckstein J.,Berdo I.,Theodoras A.,Pagano M.,Draetta G.

Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP).

Proc. Natl. Acad. Sci. U.S.A.

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1995

614384

Guinn B.-A.,Bland E.A.,Lodi U.,Liggins A.P.,Tobal K.,Petters S.,Wells J.W.,Banham A.H.,Mufti G.J.

Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia.

Biochem. Biophys. Res. Commun.

335

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2005

614386

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

614387

Schmutz J.,Martin J.,Terry A.,Couronne O.,Grimwood J.,Lowry S.,Gordon L.A.,Scott D.,Xie G.,Huang W.,Hellsten U.,Tran-Gyamfi M.,She X.,Prabhakar S.,Aerts A.,Altherr M.,Bajorek E.,Black S.,Branscomb E.,Caoile C.,Challacombe J.F.,Chan Y.M.,Denys M.,Detter J.C.,Escobar J.,Flowers D.,Fotopulos D.,Glavina T.,Gomez M.,Gonzales E.,Goodstein D.,Grigoriev I.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Israni S.,Jett J.,Kadner K.,Kimball H.,Kobayashi A.,Lopez F.,Lou Y.,Martinez D.,Medina C.,Morgan J.,Nandkeshwar R.,Noonan J.P.,Pitluck S.,Pollard M.,Predki P.,Priest J.,Ramirez L.,Retterer J.,Rodriguez A.,Rogers S.,Salamov A.,Salazar A.,Thayer N.,Tice H.,Tsai M.,Ustaszewska A.,Vo N.,Wheeler J.,Wu K.,Yang J.,Dickson M.,Cheng J.-F.,Eichler E.E.,Olsen A.,Pennacchio L.A.,Rokhsar D.S.,Richardson P.,Lucas S.M.,Myers R.M.,Rubin E.M.

The DNA sequence and comparative analysis of human chromosome 5.

Nature

431

268-274

2004

614389

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

614391

Gonen H.,Bercovich B.,Orian A.,Carrano A.,Takizawa C.,Yamanaka K.,Pagano M.,Iwai K.,Ciechanover A.

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.

J. Biol. Chem.

274

14823-14830

1999

614392

Strack P.,Caligiuri M.,Pelletier M.,Boisclair M.,Theodoras A.,Beer-Romero P.,Glass S.,Parsons T.,Copeland R.A.,Auger K.R.,Benfield P.,Brizuela L.,Rolfe M.

SCF(beta-TRCP) and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4.

Oncogene

19

3529-3536

2000

614393

Yu P.,Chen Y.,Tagle D.A.,Cai T.

PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain.

Genomics

79

869-874

2002

614394

Saville M.K.,Sparks A.,Xirodimas D.P.,Wardrop J.,Stevenson L.F.,Bourdon J.C.,Woods Y.L.,Lane D.P.

Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.

J. Biol. Chem.

279

42169-42181

2004

614395

Winkler G.S.,Albert T.K.,Dominguez C.,Legtenberg Y.I.,Boelens R.,Timmers H.T.

An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair.

J. Mol. Biol.

337

157-165

2004

614396

Hoeller D.,Hecker C.M.,Wagner S.,Rogov V.,Doetsch V.,Dikic I.

E3-independent monoubiquitination of ubiquitin-binding proteins.

Mol. Cell

26

891-898

2007

614397

Windheim M.,Peggie M.,Cohen P.

Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology.

Biochem. J.

409

723-729

2008

614398

Chiang M.H.,Chen L.F.,Chen H.

Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation.

Biol. Reprod.

79

914-920

2008

614399

Grou C.P.,Carvalho A.F.,Pinto M.P.,Wiese S.,Piechura H.,Meyer H.E.,Warscheid B.,Sa-Miranda C.,Azevedo J.E.

Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor.

J. Biol. Chem.

283

14190-14197

2008

614400

Zeng W.,Xu M.,Liu S.,Sun L.,Chen Z.J.

Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3.

Mol. Cell

36

315-325

2009

614401

Zeng W.,Sun L.,Jiang X.,Chen X.,Hou F.,Adhikari A.,Xu M.,Chen Z.J.

Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity.

Cell

141

315-330

2010

614402

David Y.,Ziv T.,Admon A.,Navon A.

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

J. Biol. Chem.

285

8595-8604

2010

614403

Ryan P.E.,Sivadasan-Nair N.,Nau M.M.,Nicholas S.,Lipkowitz S.

The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.

J. Biol. Chem.

285

23687-23698

2010

614404

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

614405

Peng H.,Yang J.,Li G.,You Q.,Han W.,Li T.,Gao D.,Xie X.,Lee B.H.,Du J.,Hou J.,Zhang T.,Rao H.,Huang Y.,Li Q.,Zeng R.,Hui L.,Wang H.,Xia Q.,Zhang X.,He Y.,Komatsu M.,Dikic I.,Finley D.,Hu R.

Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.

Cell Res.

27

657-674

2017

614406

Houben K.,Dominguez C.,van Schaik F.M.,Timmers H.T.,Bonvin A.M.,Boelens R.

Solution structure of the ubiquitin-conjugating enzyme UbcH5B.

J. Mol. Biol.

344

513-526

2004

614407

Sakata E.,Satoh T.,Yamamoto S.,Yamaguchi Y.,Yagi-Utsumi M.,Kurimoto E.,Tanaka K.,Wakatsuki S.,Kato K.

Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates.

Structure

18

138-147

2010

614408

Wright J.D.,Mace P.D.,Day C.L.

Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity.

Nat. Struct. Mol. Biol.

23

45-52

2016

614409

Li S.,Liang Y.H.,Mariano J.,Metzger M.B.,Stringer D.K.,Hristova V.A.,Li J.,Randazzo P.A.,Tsai Y.C.,Ji X.,Weissman A.M.

Insights into ubiquitination from the unique clamp-like binding of the RING E3 AO7 to the E2 UbcH5B.

J. Biol. Chem.

290

30225-30239

2015

614410

Lee H.S.,Bang I.,You J.,Jeong T.K.,Kim C.R.,Hwang M.,Kim J.S.,Baek S.H.,Song J.J.,Choi H.J.

Molecular basis for PHF7-mediated ubiquitination of histone H3.

Genes Dev.

37

984-997

2023