Sequence of UBC9_HUMAN

ubiquitin-protein ligase

P63279

158

18007

617609

Yasugi T.,Howley P.M.

Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9.

Nucleic Acids Res.

24

2005-2010

1996

617610

Tachibana M.,Iwata N.,Watanabe A.,Nobukuni Y.,Ploplis B.,Kajigaya S.

Assignment of the gene for a ubiquitin-conjugating enzyme (UBE2I) to human chromosome band 16p13.3 by in situ hybridization.

Cytogenet. Cell Genet.

75

222-223

1996

617611

Watanabe T.K.,Fujiwara T.,Kawai A.,Shimizu F.,Takami S.,Hirano H.,Okuno S.,Ozaki K.,Takeda S.,Shimada Y.,Nagata M.,Takaichi A.,Takahashi E.,Nakamura Y.,Shin S.

Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle.

Cytogenet. Cell Genet.

72

86-89

1996

617612

Masson M.,Menissier-de Murcia J.,Mattei M.-G.,de Murcia G.M.,Niedergang C.P.

Poly(ADP-ribose) polymerase interacts with a novel human ubiquitin conjugating enzyme: hUbc9.

Gene

190

287-296

1997

617613

Kovalenko O.V.,Plug A.W.,Haaf T.,Gonda D.K.,Ashley T.,Ward D.C.,Radding C.M.,Golub E.I.

Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes.

Proc. Natl. Acad. Sci. U.S.A.

93

2958-2963

1996

617614

Jiang W.,Koltin Y.

Two-hybrid interaction of a human UBC9 homolog with centromere proteins of Saccharomyces cerevisiae.

Mol. Gen. Genet.

251

153-160

1996

617615

Wang Z.-Y.,Qiu Q.,Seufert W.,Taguchi T.,Testa J.R.,Whitmore S.A.,Callen D.F.,Welsh D.,Shenk T.,Deuel T.F.

Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9.

J. Biol. Chem.

271

24811-24816

1996

617617

Hahn S.L.,Criqui-Filipe P.,Wasylyk B.

Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin-conjugating enzyme.

Oncogene

15

1489-1495

1997

617620

Daniels R.J.,Peden J.F.,Lloyd C.,Horsley S.W.,Clark K.,Tufarelli C.,Kearney L.,Buckle V.J.,Doggett N.A.,Flint J.,Higgs D.R.

Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

Hum. Mol. Genet.

10

339-352

2001

617622

Martin J.,Han C.,Gordon L.A.,Terry A.,Prabhakar S.,She X.,Xie G.,Hellsten U.,Chan Y.M.,Altherr M.,Couronne O.,Aerts A.,Bajorek E.,Black S.,Blumer H.,Branscomb E.,Brown N.C.,Bruno W.J.,Buckingham J.M.,Callen D.F.,Campbell C.S.,Campbell M.L.,Campbell E.W.,Caoile C.,Challacombe J.F.,Chasteen L.A.,Chertkov O.,Chi H.C.,Christensen M.,Clark L.M.,Cohn J.D.,Denys M.,Detter J.C.,Dickson M.,Dimitrijevic-Bussod M.,Escobar J.,Fawcett J.J.,Flowers D.,Fotopulos D.,Glavina T.,Gomez M.,Gonzales E.,Goodstein D.,Goodwin L.A.,Grady D.L.,Grigoriev I.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Hildebrand C.E.,Huang W.,Israni S.,Jett J.,Jewett P.B.,Kadner K.,Kimball H.,Kobayashi A.,Krawczyk M.-C.,Leyba T.,Longmire J.L.,Lopez F.,Lou Y.,Lowry S.,Ludeman T.,Manohar C.F.,Mark G.A.,McMurray K.L.,Meincke L.J.,Morgan J.,Moyzis R.K.,Mundt M.O.,Munk A.C.,Nandkeshwar R.D.,Pitluck S.,Pollard M.,Predki P.,Parson-Quintana B.,Ramirez L.,Rash S.,Retterer J.,Ricke D.O.,Robinson D.L.,Rodriguez A.,Salamov A.,Saunders E.H.,Scott D.,Shough T.,Stallings R.L.,Stalvey M.,Sutherland R.D.,Tapia R.,Tesmer J.G.,Thayer N.,Thompson L.S.,Tice H.,Torney D.C.,Tran-Gyamfi M.,Tsai M.,Ulanovsky L.E.,Ustaszewska A.,Vo N.,White P.S.,Williams A.L.,Wills P.L.,Wu J.-R.,Wu K.,Yang J.,DeJong P.,Bruce D.,Doggett N.A.,Deaven L.,Schmutz J.,Grimwood J.,Richardson P.,Rokhsar D.S.,Eichler E.E.,Gilna P.,Lucas S.M.,Myers R.M.,Rubin E.M.,Pennacchio L.A.

The sequence and analysis of duplication-rich human chromosome 16.

Nature

432

988-994

2004

617623

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

617624

Hateboer G.,Hijmans E.M.,Nooij J.B.D.,Schlenker S.,Jentsch S.,Bernards R.

mUBC9, a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect.

J. Biol. Chem.

271

25906-25911

1996

617625

Hu G.,Zhang S.,Vidal M.,Baer J.L.,Xu T.,Fearon E.R.

Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway.

Genes Dev.

11

2701-2714

1997

617626

Poukka H.,Aarnisalo P.,Karvonen U.,Palvimo J.J.,Jaenne O.A.

Ubc9 interacts with the androgen receptor and activates receptor-dependent transcription.

J. Biol. Chem.

274

19441-19446

1999

617627

Shi Y.,Zou M.,Farid N.R.,Paterson M.C.

Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9.

Biochem. J.

352

443-448

2000

617628

Tatham M.H.,Jaffray E.,Vaughan O.A.,Desterro J.M.P.,Botting C.H.,Naismith J.H.,Hay R.T.

Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.

J. Biol. Chem.

276

35368-35374

2001

617629

Eloranta J.J.,Hurst H.C.

Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.

J. Biol. Chem.

277

30798-30804

2002

617630

Tatham M.H.,Chen Y.,Hay R.T.

Role of two residues proximal to the active site of Ubc9 in substrate recognition by the Ubc9.SUMO-1 thiolester complex.

Biochemistry

42

3168-3179

2003

617631

Maeda A.,Lee B.H.,Yoshimatsu K.,Saijo M.,Kurane I.,Arikawa J.,Morikawa S.

The intracellular association of the nucleocapsid protein (NP) of hantaan virus (HTNV) with small ubiquitin-like modifier-1 (SUMO-1) conjugating enzyme 9 (Ubc9).

Virology

305

288-297

2003

617632

Tatham M.H.,Kim S.,Yu B.,Jaffray E.,Song J.,Zheng J.,Rodriguez M.S.,Hay R.T.,Chen Y.

Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation.

Biochemistry

42

9959-9969

2003

617633

Pichler A.,Knipscheer P.,Saitoh H.,Sixma T.K.,Melchior F.

The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type.

Nat. Struct. Mol. Biol.

11

984-991

2004

617634

Kim Y.E.,Kim D.Y.,Lee J.M.,Kim S.T.,Han T.H.,Ahn J.H.

Requirement of the coiled-coil domain of PML-RARalpha oncoprotein for localization, sumoylation, and inhibition of monocyte differentiation.

Biochem. Biophys. Res. Commun.

330

746-754

2005

617635

Tatham M.H.,Kim S.,Jaffray E.,Song J.,Chen Y.,Hay R.T.

Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection.

Nat. Struct. Mol. Biol.

12

67-74

2005

617636

Li T.,Santockyte R.,Shen R.-F.,Tekle E.,Wang G.,Yang D.C.H.,Chock P.B.

A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.

Arch. Biochem. Biophys.

453

70-74

2006

617637

Pan X.,Li H.,Zhang P.,Jin B.,Man J.,Tian L.,Su G.,Zhao J.,Li W.,Liu H.,Gong W.,Zhou T.,Zhang X.

Ubc9 interacts with SOX4 and represses its transcriptional activity.

Biochem. Biophys. Res. Commun.

344

727-734

2006

617638

Tomoiu A.,Gravel A.,Tanguay R.M.,Flamand L.

Functional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation.

J. Virol.

80

10218-10228

2006

617639

Carbia-Nagashima A.,Gerez J.,Perez-Castro C.,Paez-Pereda M.,Silberstein S.,Stalla G.K.,Holsboer F.,Arzt E.

RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia.

Cell

131

309-323

2007

617640

Cheng Z.,Ke Y.,Ding X.,Wang F.,Wang H.,Wang W.,Ahmed K.,Liu Z.,Xu Y.,Aikhionbare F.,Yan H.,Liu J.,Xue Y.,Yu J.,Powell M.,Liang S.,Wu Q.,Reddy S.E.,Hu R.,Huang H.,Jin C.,Yao X.

Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response.

Oncogene

27

931-941

2008

617641

Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

Anal. Chem.

81

4493-4501

2009

617642

Lee B.,Muller M.T.

SUMOylation enhances DNA methyltransferase 1 activity.

Biochem. J.

421

449-461

2009

617643

Kuo F.T.,Bentsi-Barnes I.K.,Barlow G.M.,Bae J.,Pisarska M.D.

Sumoylation of forkhead L2 by Ubc9 is required for its activity as a transcriptional repressor of the steroidogenic acute regulatory gene.

Cell. Signal.

21

1935-1944

2009

617644

Figueroa-Romero C.,Iniguez-Lluhi J.A.,Stadler J.,Chang C.R.,Arnoult D.,Keller P.J.,Hong Y.,Blackstone C.,Feldman E.L.

SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle.

FASEB J.

23

3917-3927

2009

617645

Chang T.H.,Kubota T.,Matsuoka M.,Jones S.,Bradfute S.B.,Bray M.,Ozato K.

Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery.

PLoS Pathog.

5

e1000493-e1000493

2009

617646

Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.

Lysine acetylation targets protein complexes and co-regulates major cellular functions.

Science

325

834-840

2009

617647

Yousef A.F.,Fonseca G.J.,Pelka P.,Ablack J.N.,Walsh C.,Dick F.A.,Bazett-Jones D.P.,Shaw G.S.,Mymryk J.S.

Identification of a molecular recognition feature in the E1A oncoprotein that binds the SUMO conjugase UBC9 and likely interferes with polySUMOylation.

Oncogene

29

4693-4704

2010

617648

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

617649

Cong L.,Pakala S.B.,Ohshiro K.,Li D.Q.,Kumar R.

SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.

J. Biol. Chem.

286

43793-43808

2011

617650

Bentz G.L.,Whitehurst C.B.,Pagano J.S.

Epstein-Barr virus latent membrane protein 1 (LMP1) C-terminal-activating region 3 contributes to LMP1-mediated cellular migration via its interaction with Ubc9.

J. Virol.

85

10144-10153

2011

617651

Bennett R.L.,Pan Y.,Christian J.,Hui T.,May W.S. Jr.

The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G(1) arrest.

Cell Cycle

11

407-417

2012

617652

Su Y.F.,Yang T.,Huang H.,Liu L.F.,Hwang J.

Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity.

PLoS ONE

7

E34250-E34250

2012

617653

Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Proc. Natl. Acad. Sci. U.S.A.

109

12449-12454

2012

617654

Richard P.,Feng S.,Manley J.L.

A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage.

Genes Dev.

27

2227-2232

2013

617655

Oh Y.,Chung K.C.

UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131.

J. Biol. Chem.

288

9102-9111

2013

617656

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

617657

Druker J.,Liberman A.C.,Antunica-Noguerol M.,Gerez J.,Paez-Pereda M.,Rein T.,Iniguez-Lluhi J.A.,Holsboer F.,Arzt E.

RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity.

Mol. Cell. Biol.

33

2116-2127

2013

617658

Gerez J.,Fuertes M.,Tedesco L.,Silberstein S.,Sevlever G.,Paez-Pereda M.,Holsboer F.,Turjanski A.G.,Arzt E.

In silico structural and functional characterization of the RSUME splice variants.

PLoS ONE

8

E57795-E57795

2013

617659

Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J. Proteomics

96

253-262

2014

617660

Hendriks I.A.,D'Souza R.C.,Yang B.,Verlaan-de Vries M.,Mann M.,Vertegaal A.C.

Uncovering global SUMOylation signaling networks in a site-specific manner.

Nat. Struct. Mol. Biol.

21

927-936

2014

617661

Impens F.,Radoshevich L.,Cossart P.,Ribet D.

Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

Proc. Natl. Acad. Sci. U.S.A.

111

12432-12437

2014

617662

Hendriks I.A.,Treffers L.W.,Verlaan-de Vries M.,Olsen J.V.,Vertegaal A.C.

SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

Cell Rep.

10

1778-1791

2015

617663

Xiao Z.,Chang J.G.,Hendriks I.A.,Sigurdsson J.O.,Olsen J.V.,Vertegaal A.C.

System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

Mol. Cell. Proteomics

14

1419-1434

2015

617664

Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.

N-terminome analysis of the human mitochondrial proteome.

Proteomics

15

2519-2524

2015

617665

Sin Y.,Tanaka K.,Saijo M.

The C-terminal Region and SUMOylation of Cockayne Syndrome Group B Protein Play Critical Roles in Transcription-coupled Nucleotide Excision Repair.

J. Biol. Chem.

291

1387-1397

2016

617666

Yamashita D.,Moriuchi T.,Osumi T.,Hirose F.

Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2alpha.

J. Biol. Chem.

291

11619-11634

2016

617667

Liang Y.C.,Lee C.C.,Yao Y.L.,Lai C.C.,Schmitz M.L.,Yang W.M.

SUMO5, a novel poly-sumo isoform, regulates pml nuclear bodies.

Sci. Rep.

6

26509-26509

2016

617668

Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

Nat. Struct. Mol. Biol.

24

325-336

2017

617669

Chen J.,Li G.,He H.,Li X.,Niu W.,Cao D.,Shen A.

Sumoylation of the Carboxy-Terminal of Human Cytomegalovirus DNA Polymerase Processivity Factor UL44 Attenuates Viral DNA Replication.

Front. Microbiol.

12

652719-652719

2021

617670

Tong H.,Hateboer G.,Perrakis A.,Bernards R.,Sixma T.K.

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system.

J. Biol. Chem.

272

21381-21387

1997

617671

Bernier-Villamor V.,Sampson D.A.,Matunis M.J.,Lima C.D.

Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1.

Cell

108

345-356

2002

617672

Reverter D.,Lima C.D.

Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex.

Nature

435

687-692

2005

617673

Yunus A.A.,Lima C.D.

Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway.

Nat. Struct. Mol. Biol.

13

491-499

2006

617674

Capili A.D.,Lima C.D.

Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction.

J. Mol. Biol.

369

608-618

2007

617675

Sekiyama N.,Arita K.,Ikeda Y.,Hashiguchi K.,Ariyoshi M.,Tochio H.,Saitoh H.,Shirakawa M.

Structural basis for regulation of poly-SUMO chain by a SUMO-like domain of Nip45.

Proteins

78

1491-1502

2010

617676

Grunwald M.,Bono F.

Structure of Importin13-Ubc9 complex: nuclear import and release of a key regulator of sumoylation.

EMBO J.

30

427-438

2011

617677

Alontaga A.Y.,Ambaye N.D.,Li Y.J.,Vega R.,Chen C.H.,Bzymek K.P.,Williams J.C.,Hu W.,Chen Y.

RWD domain as an E2 (Ubc9)-interaction module.

J. Biol. Chem.

290

16550-16559

2015

617678

Cappadocia L.,Pichler A.,Lima C.D.

Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase.

Nat. Struct. Mol. Biol.

22

968-975

2015