Sequence of UB2D3_HUMAN

ubiquitin-protein ligase

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Identification of a family of closely related human ubiquitin conjugating enzymes.

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608165

Hillier L.W.,Graves T.A.,Fulton R.S.,Fulton L.A.,Pepin K.H.,Minx P.,Wagner-McPherson C.,Layman D.,Wylie K.,Sekhon M.,Becker M.C.,Fewell G.A.,Delehaunty K.D.,Miner T.L.,Nash W.E.,Kremitzki C.,Oddy L.,Du H.,Sun H.,Bradshaw-Cordum H.,Ali J.,Carter J.,Cordes M.,Harris A.,Isak A.,van Brunt A.,Nguyen C.,Du F.,Courtney L.,Kalicki J.,Ozersky P.,Abbott S.,Armstrong J.,Belter E.A.,Caruso L.,Cedroni M.,Cotton M.,Davidson T.,Desai A.,Elliott G.,Erb T.,Fronick C.,Gaige T.,Haakenson W.,Haglund K.,Holmes A.,Harkins R.,Kim K.,Kruchowski S.S.,Strong C.M.,Grewal N.,Goyea E.,Hou S.,Levy A.,Martinka S.,Mead K.,McLellan M.D.,Meyer R.,Randall-Maher J.,Tomlinson C.,Dauphin-Kohlberg S.,Kozlowicz-Reilly A.,Shah N.,Swearengen-Shahid S.,Snider J.,Strong J.T.,Thompson J.,Yoakum M.,Leonard S.,Pearman C.,Trani L.,Radionenko M.,Waligorski J.E.,Wang C.,Rock S.M.,Tin-Wollam A.-M.,Maupin R.,Latreille P.,Wendl M.C.,Yang S.-P.,Pohl C.,Wallis J.W.,Spieth J.,Bieri T.A.,Berkowicz N.,Nelson J.O.,Osborne J.,Ding L.,Meyer R.,Sabo A.,Shotland Y.,Sinha P.,Wohldmann P.E.,Cook L.L.,Hickenbotham M.T.,Eldred J.,Williams D.,Jones T.A.,She X.,Ciccarelli F.D.,Izaurralde E.,Taylor J.,Schmutz J.,Myers R.M.,Cox D.R.,Huang X.,McPherson J.D.,Mardis E.R.,Clifton S.W.,Warren W.C.,Chinwalla A.T.,Eddy S.R.,Marra M.A.,Ovcharenko I.,Furey T.S.,Miller W.,Eichler E.E.,Bork P.,Suyama M.,Torrents D.,Waterston R.H.,Wilson R.K.

Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

Nature

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608167

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

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2121-2127

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608168

Gonen H.,Bercovich B.,Orian A.,Carrano A.,Takizawa C.,Yamanaka K.,Pagano M.,Iwai K.,Ciechanover A.

Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.

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608169

Murata S.,Minami Y.,Minami M.,Chiba T.,Tanaka K.

CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein.

EMBO Rep.

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1133-1138

2001

608170

Yogosawa S.,Miyauchi Y.,Honda R.,Tanaka H.,Yasuda H.

Mammalian Numb is a target protein of Mdm2, ubiquitin ligase.

Biochem. Biophys. Res. Commun.

302

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2003

608171

Rajendra R.,Malegaonkar D.,Pungaliya P.,Marshall H.,Rasheed Z.,Brownell J.,Liu L.F.,Lutzker S.,Saleem A.,Rubin E.H.

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.

J. Biol. Chem.

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2004

608172

Saville M.K.,Sparks A.,Xirodimas D.P.,Wardrop J.,Stevenson L.F.,Bourdon J.C.,Woods Y.L.,Lane D.P.

Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.

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608173

Huang J.,Huang Q.,Zhou X.,Shen M.M.,Yen A.,Yu S.X.,Dong G.,Qu K.,Huang P.,Anderson E.M.,Daniel-Issakani S.,Buller R.M.,Payan D.G.,Lu H.H.

The poxvirus p28 virulence factor is an E3 ubiquitin ligase.

J. Biol. Chem.

279

54110-54116

2004

608174

Polanowska J.,Martin J.S.,Garcia-Muse T.,Petalcorin M.I.R.,Boulton S.J.

A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.

EMBO J.

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608175

Hoeller D.,Hecker C.M.,Wagner S.,Rogov V.,Doetsch V.,Dikic I.

E3-independent monoubiquitination of ubiquitin-binding proteins.

Mol. Cell

26

891-898

2007

608176

Ohbayashi N.,Okada K.,Kawakami S.,Togi S.,Sato N.,Ikeda O.,Kamitani S.,Muromoto R.,Sekine Y.,Kawai T.,Akira S.,Matsuda T.

Physical and functional interactions between ZIP kinase and UbcH5.

Biochem. Biophys. Res. Commun.

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2008

608177

Zhang S.,Chea J.,Meng X.,Zhou Y.,Lee E.Y.C.,Lee M.Y.W.T.

PCNA is ubiquitinated by RNF8.

Cell Cycle

7

3399-3404

2008

608178

Umebayashi K.,Stenmark H.,Yoshimori T.

Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation.

Mol. Biol. Cell

19

3454-3462

2008

608179

Saha A.,Deshaies R.J.

Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.

Mol. Cell

32

21-31

2008

608180

Kubori T.,Hyakutake A.,Nagai H.

Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions.

Mol. Microbiol.

67

1307-1319

2008

608181

David Y.,Ziv T.,Admon A.,Navon A.

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.

J. Biol. Chem.

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2010

608182

Ryan P.E.,Sivadasan-Nair N.,Nau M.M.,Nicholas S.,Lipkowitz S.

The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.

J. Biol. Chem.

285

23687-23698

2010

608183

Wu K.,Kovacev J.,Pan Z.Q.

Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.

Mol. Cell

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784-796

2010

608184

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

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17-17

2011

608185

Wenzel D.M.,Lissounov A.,Brzovic P.S.,Klevit R.E.

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.

Nature

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105-108

2011

608186

Uhler J.P.,Spaahr H.,Farge G.,Clavel S.,Larsson N.G.,Falkenberg M.,Samuelsson T.,Gustafsson C.M.

The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.

Biochem. Biophys. Res. Commun.

443

7-12

2014

608187

Peng H.,Yang J.,Li G.,You Q.,Han W.,Li T.,Gao D.,Xie X.,Lee B.H.,Du J.,Hou J.,Zhang T.,Rao H.,Huang Y.,Li Q.,Zeng R.,Hui L.,Wang H.,Xia Q.,Zhang X.,He Y.,Komatsu M.,Dikic I.,Finley D.,Hu R.

Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress.

Cell Res.

27

657-674

2017

608188

Shi Y.,Yuan B.,Zhu W.,Zhang R.,Li L.,Hao X.,Chen S.,Hou F.

Ube2D3 and Ube2N are essential for RIG-I-mediated MAVS aggregation in antiviral innate immunity.

Nat. Commun.

8

15138-15138

2017

608189

Garzia A.,Jafarnejad S.M.,Meyer C.,Chapat C.,Gogakos T.,Morozov P.,Amiri M.,Shapiro M.,Molina H.,Tuschl T.,Sonenberg N.

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs.

Nat. Commun.

8

16056-16056

2017

608190

Jiang C.,Dai X.,He S.,Zhou H.,Fang L.,Guo J.,Liu S.,Zhang T.,Pan W.,Yu H.,Fu T.,Li D.,Inuzuka H.,Wang P.,Xiao J.,Wei W.

Ring domains are essential for GATOR2-dependent mTORC1 activation.

Mol. Cell

83

74-89

2023

608191

Brzovic P.S.,Lissounov A.,Christensen D.E.,Hoyt D.W.,Klevit R.E.

A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination.

Mol. Cell

21

873-880

2006