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Sequence of TTLL5_HUMAN

EC Number:6.3.2.61

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
tubulin-glutamate ligase
Q6EMB2
Homo sapiens
1281
143577
Reaction
ATP + [tubulin]-(alpha-L-glutamyl-gamma-L-glutamyl)-L-glutamate + n L-glutamate = [tubulin]-(gamma-(poly-alpha-L-glutamyl)-L-glutamyl)-L-glutamate + n ADP + n phosphate

General information:

Sequence
show sequence in fasta format
   0 MPIVMARDLE ETASSSEDEE VISQEDHPCI MWTGGCRRIP VLVFHADAIL TKDNNIRVIG
  60 ERYHLSYKIV RTDSRLVRSI LTAHGFHEVH PSSTDYNLMW TGSHLKPFLL RTLSEAQKVN
 120 HFPRSYELTR KDRLYKNIIR MQHTHGFKAF HILPQTFLLP AEYAEFCNSY SKDRGPWIVK
 180 PVASSRGRGV YLINNPNQIS LEENILVSRY INNPLLIDDF KFDVRLYVLV TSYDPLVIYL
 240 YEEGLARFAT VRYDQGAKNI RNQFMHLTNY SVNKKSGDYV SCDDPEVEDY GNKWSMSAML
 300 RYLKQEGRDT TALMAHVEDL IIKTIISAEL AIATACKTFV PHRSSCFELY GFDVLIDSTL
 360 KPWLLEVNLS PSLACDAPLD LKIKASMISD MFTVVGFVCQ DPAQRASTRP IYPTFESSRR
 420 NPFQKPQRCR PLSASDAEMK NLVGSAREKG PGKLGGSVLG LSMEEIKVLR RVKEENDRRG
 480 GFIRIFPTSE TWEIYGSYLE HKTSMNYMLA TRLFQDRMTA DGAPELKIES LNSKAKLHAA
 540 LYERKLLSLE VRKRRRRSSR LRAMRPKYPV ITQPAEMNVK TETESEEEEE VALDNEDEEQ
 600 EASQEESAGF LRENQAKYTP SLTALVENTP KENSMKVREW NNKGGHCCKL ETQELEPKFN
 660 LMQILQDNGN LSKMQARIAF SAYLQHVQIR LMKDSGGQTF SASWAAKEDE QMELVVRFLK
 720 RASNNLQHSL RMVLPSRRLA LLERRRILAH QLGDFIIVYN KETEQMAEKK SKKKVEEEEE
 780 DGVNMENFQE FIRQASEAEL EEVLTFYTQK NKSASVFLGT HSKISKNNNN YSDSGAKGDH
 840 PETIMEEVKI KPPKQQQTTE IHSDKLSRFT TSAEKEAKLV YSNSSSGPTA TLQKIPNTHL
 900 SSVTTSDLSP GPCHHSSLSQ IPSAIPSMPH QPTILLNTVS ASASPCLHPG AQNIPSPTGL
 960 PRCRSGSHTI GPFSSFQSAA HIYSQKLSRP SSAKAGSCYL NKHHSGIAKT QKEGEDASLY
1020 SKRYNQSMVT AELQRLAEKQ AARQYSPSSH INLLTQQVTN LNLATGIINR SSASAPPTLR
1080 PIISPSGPTW STQSDPQAPE NHSSSPGSRS LQTGGFAWEG EVENNVYSQA TGVVPQHKYH
1140 PTAGSYQLQF ALQQLEQQKL QSRQLLDQSR ARHQAIFGSQ TLPNSNLWTM NNGAGCRISS
1200 ATASGQKPTT LPQKVVPPPS SCASLVPKPP PNHEQVLRRA TSQKASKGSS AEGQLNGLQS
1260 SLNPAAFVPI TSSTDPAHTK I
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
940354
He Y.,Simons S.S. Jr.
STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression.
Mol. Cell. Biol.
27
1467-1485
2007
940355
Heilig R.,Eckenberg R.,Petit J.-L.,Fonknechten N.,Da Silva C.,Cattolico L.,Levy M.,Barbe V.,De Berardinis V.,Ureta-Vidal A.,Pelletier E.,Vico V.,Anthouard V.,Rowen L.,Madan A.,Qin S.,Sun H.,Du H.,Pepin K.,Artiguenave F.,Robert C.,Cruaud C.,Bruels T.,Jaillon O.,Friedlander L.,Samson G.,Brottier P.,Cure S.,Segurens B.,Aniere F.,Samain S.,Crespeau H.,Abbasi N.,Aiach N.,Boscus D.,Dickhoff R.,Dors M.,Dubois I.,Friedman C.,Gouyvenoux M.,James R.,Madan A.,Mairey-Estrada B.,Mangenot S.,Martins N.,Menard M.,Oztas S.,Ratcliffe A.,Shaffer T.,Trask B.,Vacherie B.,Bellemere C.,Belser C.,Besnard-Gonnet M.,Bartol-Mavel D.,Boutard M.,Briez-Silla S.,Combette S.,Dufosse-Laurent V.,Ferron C.,Lechaplais C.,Louesse C.,Muselet D.,Magdelenat G.,Pateau E.,Petit E.,Sirvain-Trukniewicz P.,Trybou A.,Vega-Czarny N.,Bataille E.,Bluet E.,Bordelais I.,Dubois M.,Dumont C.,Guerin T.,Haffray S.,Hammadi R.,Muanga J.,Pellouin V.,Robert D.,Wunderle E.,Gauguet G.,Roy A.,Sainte-Marthe L.,Verdier J.,Verdier-Discala C.,Hillier L.W.,Fulton L.,McPherson J.,Matsuda F.,Wilson R.,Scarpelli C.,Gyapay G.,Wincker P.,Saurin W.,Quetier F.,Waterston R.,Hood L.,Weissenbach J.
The DNA sequence and analysis of human chromosome 14.
Nature
421
601-607
2003
940357
Wiemann S.,Weil B.,Wellenreuther R.,Gassenhuber J.,Glassl S.,Ansorge W.,Boecher M.,Bloecker H.,Bauersachs S.,Blum H.,Lauber J.,Duesterhoeft A.,Beyer A.,Koehrer K.,Strack N.,Mewes H.-W.,Ottenwaelder B.,Obermaier B.,Tampe J.,Heubner D.,Wambutt R.,Korn B.,Klein M.,Poustka A.
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
Genome Res.
11
422-435
2001
940359
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
940360
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
940361
Nagase T.,Ishikawa K.,Suyama M.,Kikuno R.,Hirosawa M.,Miyajima N.,Tanaka A.,Kotani H.,Nomura N.,Ohara O.
Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
DNA Res.
6
63-70
1999
940362
Backer C.B.,Gutzman J.H.,Pearson C.G.,Cheeseman I.M.
CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development.
Mol. Biol. Cell
23
2122-2130
2012
940363
Sergouniotis P.I.,Chakarova C.,Murphy C.,Becker M.,Lenassi E.,Arno G.,Lek M.,MacArthur D.G.,Bhattacharya S.S.,Moore A.T.,Holder G.E.,Robson A.G.,Wolfrum U.,Webster A.R.,Plagnol V.
Biallelic variants in TTLL5, encoding a tubulin glutamylase, cause retinal dystrophy.
Am. J. Hum. Genet.
94
760-769
2014
940364
Garnham C.P.,Vemu A.,Wilson-Kubalek E.M.,Yu I.,Szyk A.,Lander G.C.,Milligan R.A.,Roll-Mecak A.
Multivalent microtubule recognition by tubulin tyrosine ligase-like family glutamylases.
Cell
161
1112-1123
2015