Sequence of AK1C2_HUMAN

3alpha-hydroxysteroid 3-dehydrogenase

P52895

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581948

Qin K.-N.,New M.I.,Cheng K.-C.

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

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673-679

1993

581949

Ciaccio P.J.,Tew K.D.

cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.

Biochim. Biophys. Acta

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129-132

1994

581950

Qin K.-N.,Khanna M.,Cheng K.-C.

Structure of a gene coding for human dihydrodiol dehydrogenase/bile acid-binding protein.

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1994

581951

Dufort I.,Soucy P.,Labrie F.,Luu-The V.

Molecular cloning of human type 3 3 alpha-hydroxysteroid dehydrogenase that differs from 20 alpha-hydroxysteroid dehydrogenase by seven amino acids.

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1996

581952

Shiraishi H.,Ishikura S.,Matsuura K.,Deyashiki Y.,Ninomiya M.,Sakai S.,Hara A.

Sequence of the cDNA of a human dihydrodiol dehydrogenase isoform (AKR1C2) and tissue distribution of its mRNA.

Biochem. J.

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1998

581953

Nishizawa M.,Nakajima T.,Yasuda K.,Kanzaki H.,Sasaguri Y.,Watanabe K.,Ito S.

Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

Genes Cells

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581954

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Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

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2004

581956

Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.

The DNA sequence and comparative analysis of human chromosome 10.

Nature

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375-381

2004

581957

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

581958

Hara A.,Matsuura K.,Tamada Y.,Sato K.,Miyabe Y.,Deyashiki Y.,Ishida N.

Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.

Biochem. J.

313

373-376

1996

581959

Stolz A.,Hammond L.,Lou H.,Takikawa H.,Ronk M.,Shively J.E.

cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family.

J. Biol. Chem.

268

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1993

581960

Penning T.M.,Burczynski M.E.,Jez J.M.,Hung C.F.,Lin H.K.,Ma H.,Moore M.,Palackal N.,Ratnam K.

Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.

Biochem. J.

351

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2000

581961

Steckelbroeck S.,Jin Y.,Gopishetty S.,Oyesanmi B.,Penning T.M.

Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.

J. Biol. Chem.

279

10784-10795

2004

581962

Jin Y.,Duan L.,Lee S.H.,Kloosterboer H.J.,Blair I.A.,Penning T.M.

Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.

J. Biol. Chem.

284

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2009

581963

Fluck C.E.,Meyer-Boni M.,Pandey A.V.,Kempna P.,Miller W.L.,Schoenle E.J.,Biason-Lauber A.

Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation.

Am. J. Hum. Genet.

89

201-218

2011

581964

Jin Y.,Stayrook S.E.,Albert R.H.,Palackal N.T.,Penning T.M.,Lewis M.

Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate.

Biochemistry

40

10161-10168

2001

581965

Nahoum V.,Gangloff A.,Legrand P.,Zhu D.-W.,Cantin L.,Zhorov B.S.,Luu-The V.,Labrie F.,Breton R.,Lin S.X.

Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.

J. Biol. Chem.

276

42091-42098

2001

581966

Couture J.F.,de Jesus-Tran K.P.,Roy A.M.,Cantin L.,Cote P.L.,Legrand P.,Luu-The V.,Labrie F.,Breton R.

Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an 'induced-fit' mechanism and a conserved basic motif involved in the binding of androgen.

Protein Sci.

14

1485-1497

2005

581967

Faucher F.,Pereira de Jesus-Tran K.,Cantin L.,Luu-The V.,Labrie F.,Breton R.

Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.

J. Mol. Biol.

364

747-763

2006

581968

Faucher F.,Cantin L.,Pereira de Jesus-Tran K.,Lemieux M.,Luu-The V.,Labrie F.,Breton R.

Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.

J. Mol. Biol.

369

525-540

2007