Sequence of AK1C3_HUMAN

3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)

P42330

323

36853

545121

Qin K.-N.,New M.I.,Cheng K.-C.

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

J. Steroid Biochem. Mol. Biol.

46

673-679

1993

545122

Khanna M.,Qin K.-N.,Wang R.W.,Cheng K.-C.

Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.

J. Biol. Chem.

270

20162-20168

1995

545123

Khanna M.,Qin K.-N.,Cheng K.-C.

Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.

J. Steroid Biochem. Mol. Biol.

53

41-46

1995

545124

Lin H.-K.,Jez J.M.,Schlegel B.P.,Peehl D.M.,Pachter J.A.,Penning T.M.

Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution.

Mol. Endocrinol.

11

1971-1984

1997

545125

Suzuki-Yamamoto T.,Nishizawa M.,Fukui M.,Okuda-Ashitaka E.,Nakajima T.,Ito S.,Watanabe K.

cDNA cloning, expression and characterization of human prostaglandin F synthase.

FEBS Lett.

462

335-340

1999

545126

Griffin L.D.,Mellon S.H.

Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes.

Proc. Natl. Acad. Sci. U.S.A.

96

13512-13517

1999

545127

Nishizawa M.,Nakajima T.,Yasuda K.,Kanzaki H.,Sasaguri Y.,Watanabe K.,Ito S.

Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

Genes Cells

5

111-125

2000

545128

Penning T.M.,Burczynski M.E.,Jez J.M.,Lin H.-K.,Ma H.,Moore M.,Ratnam K.,Palackal N.

Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3).

Mol. Cell. Endocrinol.

171

137-149

2001

545129

Nagase T.,Miyajima N.,Tanaka A.,Sazuka T.,Seki N.,Sato S.,Tabata S.,Ishikawa K.,Kawarabayasi Y.,Kotani H.,Nomura N.

Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

DNA Res.

2

37-43

1995

545131

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

545132

Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.

The DNA sequence and comparative analysis of human chromosome 10.

Nature

429

375-381

2004

545134

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

545135

Dufort I.,Rheault P.,Huang X.-F.,Soucy P.,Luu-The V.

Characteristics of a highly labile human type 5 17beta-hydroxysteroid dehydrogenase.

Endocrinology

140

568-574

1999

545136

Penning T.M.,Burczynski M.E.,Jez J.M.,Hung C.F.,Lin H.K.,Ma H.,Moore M.,Palackal N.,Ratnam K.

Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.

Biochem. J.

351

67-77

2000

545137

Koda N.,Tsutsui Y.,Niwa H.,Ito S.,Woodward D.F.,Watanabe K.

Synthesis of prostaglandin F ethanolamide by prostaglandin F synthase and identification of Bimatoprost as a potent inhibitor of the enzyme: new enzyme assay method using LC/ESI/MS.

Arch. Biochem. Biophys.

424

128-136

2004

545138

Steckelbroeck S.,Jin Y.,Gopishetty S.,Oyesanmi B.,Penning T.M.

Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.

J. Biol. Chem.

279

10784-10795

2004

545139

Kabututu Z.,Manin M.,Pointud J.C.,Maruyama T.,Nagata N.,Lambert S.,Lefrancois-Martinez A.M.,Martinez A.,Urade Y.

Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7.

J. Biochem.

145

161-168

2009

545140

Byrns M.C.,Duan L.,Lee S.H.,Blair I.A.,Penning T.M.

Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer.

J. Steroid Biochem. Mol. Biol.

118

177-187

2010

545141

Ruiz F.X.,Porte S.,Gallego O.,Moro A.,Ardevol A.,Del Rio-Espinola A.,Rovira C.,Farres J.,Pares X.

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

Biochem. J.

440

335-344

2011

545142

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

545143

Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J. Proteomics

96

253-262

2014

545144

Komoto J.,Yamada T.,Watanabe K.,Takusagawa F.

Crystal structure of human prostaglandin F synthase (AKR1C3).

Biochemistry

43

2188-2198

2004

545145

Lovering A.L.,Ride J.P.,Bunce C.M.,Desmond J.C.,Cummings S.M.,White S.A.

Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin.

Cancer Res.

64

1802-1810

2004

545146

Qiu W.,Zhou M.,Labrie F.,Lin S.-X.

Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues.

Mol. Endocrinol.

18

1798-1807

2004