Sequence of TYSY_ECOLI
EC Number:2.1.1.45
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
Other sequences found for EC No. 2.1.1.45
General information:
Sequence
0 MKQYLELMQK VLDEGTQKND RTGTGTLSIF GHQMRFNLQD GFPLVTTKRC HLRSIIHELL
60 WFLQGDTNIA YLHENNVTIW DEWADENGDL GPVYGKQWRA WPTPDGRHID QITTVLNQLK
120 NDPDSRRIIV SAWNVGELDK MALAPCHAFF QFYVADGKLS CQLYQRSCDV FLGLPFNIAS
180 YALLVHMMAQ QCDLEVGDFV WTGGDTHLYS NHMDQTHLQL SREPRPLPKL IIKRKPESIF
240 DYRFEDFEIE GYDPHPGIKA PVAI
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
113499
Belfort M.,Maley G.F.,Pedersen-Lane J.,Maley F.
Primary structure of the Escherichia coli thyA gene and its thymidylate synthase product.
Proc. Natl. Acad. Sci. U.S.A.
80
4914-4918
1983
113500
Blattner F.R.,Plunkett G. III,Bloch C.A.,Perna N.T.,Burland V.,Riley M.,Collado-Vides J.,Glasner J.D.,Rode C.K.,Mayhew G.F.,Gregor J.,Davis N.W.,Kirkpatrick H.A.,Goeden M.A.,Rose D.J.,Mau B.,Shao Y.
The complete genome sequence of Escherichia coli K-12.
Science
277
1453-1462
1997
113501
Hayashi K.,Morooka N.,Yamamoto Y.,Fujita K.,Isono K.,Choi S.,Ohtsubo E.,Baba T.,Wanner B.L.,Mori H.,Horiuchi T.
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.
Mol. Syst. Biol.
2
0-0
2006
113502
Finch P.W.,Wilson R.E.,Brown K.,Hickson I.D.,Tomkinson A.E.,Emmerson P.T.
Complete nucleotide sequence of the Escherichia coli recC gene and of the thyA-recC intergenic region.
Nucleic Acids Res.
14
4437-4451
1986
113503
Maley G.F.,Maley F.
Properties of a defined mutant of Escherichia coli thymidylate synthase.
J. Biol. Chem.
263
7620-7627
1988
113504
Kim C.W.,Michaels M.L.,Miller J.F.
Amino acid substitution analysis of E. coli thymidylate synthase: the study of a highly conserved region at the N-terminus.
Proteins
13
352-363
1992
113505
Voeller D.M.,Changchien L.-M.,Maley G.F.,Maley F.,Takechi T.,Turner R.E.,Montfort W.R.,Allegra C.J.,Chu E.
Characterization of a specific interaction between Escherichia coli thymidylate synthase and Escherichia coli thymidylate synthase mRNA.
Nucleic Acids Res.
23
869-875
1995
113506
VanBogelen R.A.,Abshire K.Z.,Moldover B.,Olson E.R.,Neidhardt F.C.
Escherichia coli proteome analysis using the gene-protein database.
Electrophoresis
18
1243-1251
1997
113507
Montfort W.R.,Perry K.M.,Fauman E.B.,Finer-Moore J.S.,Maley G.F.,Hardy L.,Maley F.,Stroud R.M.
Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an anti-folate.
Biochemistry
29
6964-6977
1990
113508
Perry K.M.,Fauman E.B.,Finer-Moore J.S.,Montfort W.R.,Maley G.F.,Maley F.,Stroud R.M.
Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases.
Proteins
8
315-333
1990
113509
Fauman E.B.,Rutenber E.E.,Maley G.F.,Maley F.,Stroud R.M.
Water-mediated substrate/product discrimination: the product complex of thymidylate synthase at 1.83 A.
Biochemistry
33
1502-1511
1994
113510
Sage C.R.,Rutenber E.E.,Stout T.J.,Stroud R.M.
An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q.
Biochemistry
35
16270-16281
1996
113511
Strop P.,Changchien L.,Maley F.,Montfort W.R.
Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu.
Protein Sci.
6
2504-2511
1997
113512
Reyes C.L.,Sage C.R.,Rutenber E.E.,Nissen R.M.,Finer-Moore J.S.,Stroud R.M.
Inactivity of N229A thymidylate synthase due to water-mediated effects: isolating a late stage in methyl transfer.
J. Mol. Biol.
284
699-712
1998
113513
Erlanson D.A.,Braisted A.C.,Raphael D.R.,Randal M.,Stroud R.M.,Gordon E.M.,Wells J.A.
Site-directed ligand discovery.
Proc. Natl. Acad. Sci. U.S.A.
97
9367-9372
2000
