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Sequence of TRYB1_HUMAN

EC Number:3.4.21.59

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Tryptase
Q15661
Homo sapiens
275
30515
Reaction
Preferential cleavage: Arg-/-, Lys-/-, but with more restricted specificity than trypsin
Other sequences found for EC No. 3.4.21.59

General information:

Sequence
show sequence in fasta format
  0 MLNLLLLALP VLASRAYAAP APGQALQRVG IVGGQEAPRS KWPWQVSLRV HGPYWMHFCG
 60 GSLIHPQWVL TAAHCVGPDV KDLAALRVQL REQHLYYQDQ LLPVSRIIVH PQFYTAQIGA
120 DIALLELEEP VNVSSHVHTV TLPPASETFP PGMPCWVTGW GDVDNDERLP PPFPLKQVKV
180 PIMENHICDA KYHLGAYTGD DVRIVRDDML CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG
240 VVSWGEGCAQ PNRPGIYTRV TYYLDWIHHY VPKKP
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
112378
Miller J.S.,Westin E.H.,Schwartz L.B.
Cloning and characterization of complementary DNA for human tryptase.
J. Clin. Invest.
84
1188-1195
1989
112380
Vanderslice P.,Ballinger S.M.,Tam E.K.,Goldstein S.M.,Craik C.S.,Caughey G.H.
Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.
Proc. Natl. Acad. Sci. U.S.A.
87
3811-3815
1990
112381
Pallaoro M.,Fejzo M.S.,Shayesteh L.,Blount J.L.,Caughey G.H.
Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3.
J. Biol. Chem.
274
3355-3362
1999
112382
Jackson N.E.,Wang H.W.,Bryant K.J.,McNeil H.P.,Husain A.,Liu K.,Tedla N.,Thomas P.S.,King G.C.,Hettiaratchi A.,Cairns J.,Hunt J.E.
Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation.
J. Biol. Chem.
283
34178-34187
2008
112383
Trivedi N.N.,Tamraz B.,Chu C.,Kwok P.Y.,Caughey G.H.
Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.
J. Allergy Clin. Immunol.
124
1099-1105
2009
112384
Martin J.,Han C.,Gordon L.A.,Terry A.,Prabhakar S.,She X.,Xie G.,Hellsten U.,Chan Y.M.,Altherr M.,Couronne O.,Aerts A.,Bajorek E.,Black S.,Blumer H.,Branscomb E.,Brown N.C.,Bruno W.J.,Buckingham J.M.,Callen D.F.,Campbell C.S.,Campbell M.L.,Campbell E.W.,Caoile C.,Challacombe J.F.,Chasteen L.A.,Chertkov O.,Chi H.C.,Christensen M.,Clark L.M.,Cohn J.D.,Denys M.,Detter J.C.,Dickson M.,Dimitrijevic-Bussod M.,Escobar J.,Fawcett J.J.,Flowers D.,Fotopulos D.,Glavina T.,Gomez M.,Gonzales E.,Goodstein D.,Goodwin L.A.,Grady D.L.,Grigoriev I.,Groza M.,Hammon N.,Hawkins T.,Haydu L.,Hildebrand C.E.,Huang W.,Israni S.,Jett J.,Jewett P.B.,Kadner K.,Kimball H.,Kobayashi A.,Krawczyk M.-C.,Leyba T.,Longmire J.L.,Lopez F.,Lou Y.,Lowry S.,Ludeman T.,Manohar C.F.,Mark G.A.,McMurray K.L.,Meincke L.J.,Morgan J.,Moyzis R.K.,Mundt M.O.,Munk A.C.,Nandkeshwar R.D.,Pitluck S.,Pollard M.,Predki P.,Parson-Quintana B.,Ramirez L.,Rash S.,Retterer J.,Ricke D.O.,Robinson D.L.,Rodriguez A.,Salamov A.,Saunders E.H.,Scott D.,Shough T.,Stallings R.L.,Stalvey M.,Sutherland R.D.,Tapia R.,Tesmer J.G.,Thayer N.,Thompson L.S.,Tice H.,Torney D.C.,Tran-Gyamfi M.,Tsai M.,Ulanovsky L.E.,Ustaszewska A.,Vo N.,White P.S.,Williams A.L.,Wills P.L.,Wu J.-R.,Wu K.,Yang J.,DeJong P.,Bruce D.,Doggett N.A.,Deaven L.,Schmutz J.,Grimwood J.,Richardson P.,Rokhsar D.S.,Eichler E.E.,Gilna P.,Lucas S.M.,Myers R.M.,Rubin E.M.,Pennacchio L.A.
The sequence and analysis of duplication-rich human chromosome 16.
Nature
432
988-994
2004
112385
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
112386
Cromlish J.A.,Seidah N.G.,Marcinkiewcz M.,Hamelin J.,Johnson D.A.,Chretein M.
Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.
J. Biol. Chem.
262
1363-1373
1987
112387
Strik M.C.,Wolbink A.,Wouters D.,Bladergroen B.A.,Verlaan A.R.,van Houdt I.S.,Hijlkema S.,Hack C.E.,Kummer J.A.
Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers.
Blood
103
2710-2717
2004
112388
Fukuoka Y.,Schwartz L.B.
Active monomers of human beta-tryptase have expanded substrate specificities.
Int. Immunopharmacol.
7
1900-1908
2007
112389
Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
J. Proteome Res.
8
651-661
2009
112390
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
112391
Lyons J.J.,Yu X.,Hughes J.D.,Le Q.T.,Jamil A.,Bai Y.,Ho N.,Zhao M.,Liu Y.,O'Connell M.P.,Trivedi N.N.,Nelson C.,DiMaggio T.,Jones N.,Matthews H.,Lewis K.L.,Oler A.J.,Carlson R.J.,Arkwright P.D.,Hong C.,Agama S.,Wilson T.M.,Tucker S.,Zhang Y.,McElwee J.J.,Pao M.,Glover S.C.,Rothenberg M.E.,Hohman R.J.,Stone K.D.,Caughey G.H.,Heller T.,Metcalfe D.D.,Biesecker L.G.,Schwartz L.B.,Milner J.D.
Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.
Nat. Genet.
48
1564-1569
2016
112392
Marquardt U.,Zettl F.,Huber R.,Bode W.,Sommerhoff C.
The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region.
J. Mol. Biol.
321
491-502
2002
112393
Guida M.,Riedy M.,Lee D.,Hall J.
Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog.
Pharmacogenetics
10
389-396
2000