Sequence of NCS_THLFG
EC Number:4.2.1.78
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
4-hydroxyphenylacetaldehyde + dopamine = (S)-norcoclaurine + H2O
Other sequences found for EC No. 4.2.1.78
General information:
Sequence
0 MMKMEVVFVF LMLLGTINCQ KLILTGRPFL HHQGIINQVS TVTKVIHHEL EVAASADDIW
60 TVYSWPGLAK HLPDLLPGAF EKLEIIGDGG VGTILDMTFV PGEFPHEYKE KFILVDNEHR
120 LKKVQMIEGG YLDLGVTYYM DTIHVVPTGK DSCVIKSSTE YHVKPEFVKI VEPLITTGPL
180 AAMADAISKL VLEHKSKSNS DEIEAAIITV
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1219079
Samanani N.,Liscombe D.K.,Facchini P.J.
Molecular cloning and characterization of norcoclaurine synthase, an enzyme catalyzing the first committed step in benzylisoquinoline alkaloid biosynthesis.
Plant J.
40
302-313
2004
1219080
Luk L.Y.P.,Bunn S.,Liscombe D.K.,Facchini P.J.,Tanner M.E.
Mechanistic studies on norcoclaurine synthase of benzylisoquinoline alkaloid biosynthesis: an enzymatic Pictet-Spengler reaction.
Biochemistry
46
10153-10161
2007
1219081
Berkner H.,Engelhorn J.,Liscombe D.K.,Schweimer K.,Woehrl B.M.,Facchini P.J.,Roesch P.,Matecko I.
High-yield expression and purification of isotopically labeled norcoclaurine synthase, a Bet v 1-homologous enzyme, from Thalictrum flavum for NMR studies.
Protein Expr. Purif.
56
197-204
2007
1219082
Berkner H.,Schweimer K.,Matecko I.,Rosch P.
Conformation, catalytic site, and enzymatic mechanism of the PR10 allergen-related enzyme norcoclaurine synthase.
Biochem. J.
413
281-290
2008
1219083
Pasquo A.,Bonamore A.,Franceschini S.,Macone A.,Boffi A.,Ilari A.
Cloning, expression, crystallization and preliminary X-ray data analysis of norcoclaurine synthase from Thalictrum flavum.
Acta Crystallogr. F
64
281-283
2008
1219084
Ilari A.,Franceschini S.,Bonamore A.,Arenghi F.,Botta B.,Macone A.,Pasquo A.,Bellucci L.,Boffi A.
Structural basis of enzymatic (S)-norcoclaurine biosynthesis.
J. Biol. Chem.
284
897-904
2009