Sequence of MEP1B_HUMAN

meprin B

Q16820

701

79571

1212638

Eldering J.A.,Gruenberg J.,Hahn D.,Croes H.J.,Fransen J.A.,Sterchi E.E.

Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells.

Eur. J. Biochem.

247

920-932

1997

1212640

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

1212641

Dumermuth E.,Eldering J.A.,Gruenberg J.,Jiang W.,Sterchi E.E.

Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells.

FEBS Lett.

335

367-375

1993

1212642

Pischitzis A.,Hahn D.,Leuenberger B.,Sterchi E.E.

N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase beta (human meprinbeta). A 13-amino-acid sequence is required for proteolytic processing and subsequent secretion.

Eur. J. Biochem.

261

421-429

1999

1212643

Leuenberger B.,Hahn D.,Pischitzis A.,Hansen M.K.,Sterchi E.E.

Human meprin beta: O-linked glycans in the intervening region of the type I membrane protein protect the C-terminal region from proteolytic cleavage and diminish its secretion.

Biochem. J.

369

659-665

2003

1212644

Villa J.P.,Bertenshaw G.P.,Bond J.S.

Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity.

J. Biol. Chem.

278

42545-42550

2003

1212645

Banerjee S.,Bond J.S.

Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation.

J. Biol. Chem.

283

31371-31377

2008

1212646

Huguenin M.,Muller E.J.,Trachsel-Rosmann S.,Oneda B.,Ambort D.,Sterchi E.E.,Lottaz D.

The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion.

PLoS ONE

3

0-0

2008

1212647

Hedrich J.,Lottaz D.,Meyer K.,Yiallouros I.,Jahnen-Dechent W.,Stocker W.,Becker-Pauly C.

Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases.

Biochemistry

49

8599-8607

2010

1212648

Ambort D.,Brellier F.,Becker-Pauly C.,Stocker W.,Andrejevic-Blant S.,Chiquet M.,Sterchi E.E.

Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading.

Matrix Biol.

29

31-42

2010

1212649

Becker-Pauly C.,Barre O.,Schilling O.,Auf dem Keller U.,Ohler A.,Broder C.,Schutte A.,Kappelhoff R.,Stocker W.,Overall C.M.

Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates.

Mol. Cell. Proteomics

10

0-0

2011

1212650

Jefferson T.,Auf dem Keller U.,Bellac C.,Metz V.V.,Broder C.,Hedrich J.,Ohler A.,Maier W.,Magdolen V.,Sterchi E.,Bond J.S.,Jayakumar A.,Traupe H.,Chalaris A.,Rose-John S.,Pietrzik C.U.,Postina R.,Overall C.M.,Becker-Pauly C.

The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin beta and ADAM10.

Cell. Mol. Life Sci.

70

309-333

2013

1212651

Arolas J.L.,Broder C.,Jefferson T.,Guevara T.,Sterchi E.E.,Bode W.,Stocker W.,Becker-Pauly C.,Gomis-Ruth F.X.

Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane.

Proc. Natl. Acad. Sci. U.S.A.

109

16131-16136

2012

1212652

de Ligt J.,Willemsen M.H.,van Bon B.W.,Kleefstra T.,Yntema H.G.,Kroes T.,Vulto-van Silfhout A.T.,Koolen D.A.,de Vries P.,Gilissen C.,del Rosario M.,Hoischen A.,Scheffer H.,de Vries B.B.,Brunner H.G.,Veltman J.A.,Vissers L.E.

Diagnostic exome sequencing in persons with severe intellectual disability.

N. Engl. J. Med.

367

1921-1929

2012