Sequence of HYSA_STRPN
EC Number:4.2.2.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
hyaluronate lyase
Q54873
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
1066
120771
Reaction
[hyaluronate]n = (4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine-[hyaluronate]n-m-1 + 2 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + hyaluronate
Other sequences found for EC No. 4.2.2.1
General information:
Sequence
0 MQTKTKKLIV SLSSLVLSGF LLNHYMTIGA EETTTNTIQQ SQKEVQYQQR DTKNLVENGD
60 FGQTEDGSSP WTGSKAQGWS AWVDQKNSAD ASTRVIEAKD GAITISSHEK LRAALHRMVP
120 IEAKKKYKLR FKIKTDNKIG IAKVRIIEES GKDKRLWNSA TTSGTKDWQT IEADYSPTLD
180 VDKIKLELFY ETGTGTVSFK DIELVEVADQ LSEDSQTDKQ LEEKIDLPIG KKHVFSLADY
240 TYKVENPDVA SVKNGILEPL KEGTTNVIVS KDGKEVKKIP LKILASVKDA YTDRLDDWNG
300 IIAGNQYYDS KNEQMAKLNQ ELEGKVADSL SSISSQADRT YLWEKFSNYK TSANLTATYR
360 KLEEMAKQVT NPSSRYYQDE TVVRTVRDSM EWMHKHVYNS EKSIVGNWWD YEIGTPRAIN
420 NTLSLMKEYF SDEEIKKYTD VIEKFVPDPE HFRKTTDNPF KALGGNLVDM GRVKVIAGLL
480 RKDDQEISST IRSIEQVFKL VDQGEGFYQD GSYIDHTNVA YTGAYGNVLI DGLSQLLPVI
540 QKTKNPIDKD KMQTMYHWID KSFAPLLVNG ELMDMSRGRS ISRANSEGHV AAVEVLRGIH
600 RIADMSEGET KQCLQSLVKT IVQSDSYYDV FKNLKTYKDI SLMQSLLSDA GVASVPRPSY
660 LSAFNKMDKT AMYNAEKGFG FGLSLFSSRT LNYEHMNKEN KRGWYTSDGM FYLYNGDLSH
720 YSDGYWPTVN PYKMPGTTET DAKRADSDTG KVLPSAFVGT SKLDDANATA TMDFTNWNQT
780 LTAHKSWFML KDKIAFLGSN IQNTSTDTAA TTIDQRKLES GNPYKVYVND KEASLTEQEK
840 DYPETQSVFL ESFDSKKNIG YFFFKKSSIS MSKALQKGAW KDINEGQSDK EVENEFLTIS
900 QAHKQNRDSY GYMLIPNVDR ATFNQMIKEL ESSLIENNET LQSVYDAKQG VWGIVKYDDS
960 VSTISNQFQV LKRGVYTIRK EGDEYKIAYY NPETQESAPD QEVFKKLEQA AQPQVQNSKE
1020 KEKSEEEKNH SDQKNLPQTG EGQSILASLG FLLLGAFYLF RRGKNN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1199741
Tettelin H.,Nelson K.E.,Paulsen I.T.,Eisen J.A.,Read T.D.,Peterson S.N.,Heidelberg J.F.,DeBoy R.T.,Haft D.H.,Dodson R.J.,Durkin A.S.,Gwinn M.L.,Kolonay J.F.,Nelson W.C.,Peterson J.D.,Umayam L.A.,White O.,Salzberg S.L.,Lewis M.R.,Radune D.,Holtzapple E.K.,Khouri H.M.,Wolf A.M.,Utterback T.R.,Hansen C.L.,McDonald L.A.,Feldblyum T.V.,Angiuoli S.V.,Dickinson T.,Hickey E.K.,Holt I.E.,Loftus B.J.,Yang F.,Smith H.O.,Venter J.C.,Dougherty B.A.,Morrison D.A.,Hollingshead S.K.,Fraser C.M.
Complete genome sequence of a virulent isolate of Streptococcus pneumoniae.
Science
293
498-506
2001
1199742
Berry A.M.,Lock R.A.,Thomas S.M.,Rajan D.P.,Hansman D.,Paton J.C.
Cloning and nucleotide sequence of the Streptococcus pneumoniae hyaluronidase gene and purification of the enzyme from recombinant Escherichia coli.
Infect. Immun.
62
1101-1108
1994
1199743
Jedrzejas M.J.,Chantalat L.,Mewbourne R.B.
Crystallization and preliminary X-ray analysis of Streptococcus pneumoniae hyaluronate lyase.
J. Struct. Biol.
121
73-75
1998
1199744
Li S.,Kelly S.J.,Lamani E.,Ferraroni M.,Jedrzejas M.J.
Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase.
EMBO J.
19
1228-1240
2000
