Sequence of TNAP3_HUMAN
EC Number:3.4.19.12
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)
Other sequences found for EC No. 3.4.19.12
General information:
Sequence
0 MAEQVLPQAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHF KTMHRYTLEM FRTCQFCPQF
60 REIIHKALID RNIQATLESQ KKLNWCREVR KLVALKTNGD GNCLMHATSQ YMWGVQDTDL
120 VLRKALFSTL KETDTRNFKF RWQLESLKSQ EFVETGLCYD TRNWNDEWDN LIKMASTDTP
180 MARSGLQYNS LEEIHIFVLC NILRRPIIVI SDKMLRSLES GSNFAPLKVG GIYLPLHWPA
240 QECYRYPIVL GYDSHHFVPL VTLKDSGPEI RAVPLVNRDR GRFEDLKVHF LTDPENEMKE
300 KLLKEYLMVI EIPVQGWDHG TTHLINAAKL DEANLPKEIN LVDDYFELVQ HEYKKWQENS
360 EQGRREGHAQ NPMEPSVPQL SLMDVKCETP NCPFFMSVNT QPLCHECSER RQKNQNKLPK
420 LNSKPGPEGL PGMALGASRG EAYEPLAWNP EESTGGPHSA PPTAPSPFLF SETTAMKCRS
480 PGCPFTLNVQ HNGFCERCHN ARQLHASHAP DHTRHLDPGK CQACLQDVTR TFNGICSTCF
540 KRTTAEASSS LSTSLPPSCH QRSKSDPSRL VRSPSPHSCH RAGNDAPAGC LSQAARTPGD
600 RTGTSKCRKA GCVYFGTPEN KGFCTLCFIE YRENKHFAAA SGKVSPTASR FQNTIPCLGR
660 ECGTLGSTMF EGYCQKCFIE AQNQRFHEAK RTEEQLRSSQ RRDVPRTTQS TSRPKCARAS
720 CKNILACRSE ELCMECQHPN QRMGPGAHRG EPAPEDPPKQ RCRAPACDHF GNAKCNGYCN
780 ECFQFKQMYG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
109960
Opipari A.W. Jr.,Boguski M.S.,Dixit V.M.
The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.
J. Biol. Chem.
265
14705-14708
1990
109961
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
109963
Mungall A.J.,Palmer S.A.,Sims S.K.,Edwards C.A.,Ashurst J.L.,Wilming L.,Jones M.C.,Horton R.,Hunt S.E.,Scott C.E.,Gilbert J.G.R.,Clamp M.E.,Bethel G.,Milne S.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Andrews T.D.,Ashwell R.I.S.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Barker D.J.,Barlow K.F.,Bates K.,Beare D.M.,Beasley H.,Beasley O.,Bird C.P.,Blakey S.E.,Bray-Allen S.,Brook J.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Carder C.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clark G.,Clee C.M.,Clegg S.,Cobley V.,Collier R.E.,Collins J.E.,Colman L.K.,Corby N.R.,Coville G.J.,Culley K.M.,Dhami P.,Davies J.,Dunn M.,Earthrowl M.E.,Ellington A.E.,Evans K.A.,Faulkner L.,Francis M.D.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Ghori M.J.,Gilby L.M.,Gillson C.J.,Glithero R.J.,Grafham D.V.,Grant M.,Gribble S.,Griffiths C.,Griffiths M.N.D.,Hall R.,Halls K.S.,Hammond S.,Harley J.L.,Hart E.A.,Heath P.D.,Heathcott R.,Holmes S.J.,Howden P.J.,Howe K.L.,Howell G.R.,Huckle E.,Humphray S.J.,Humphries M.D.,Hunt A.R.,Johnson C.M.,Joy A.A.,Kay M.,Keenan S.J.,Kimberley A.M.,King A.,Laird G.K.,Langford C.,Lawlor S.,Leongamornlert D.A.,Leversha M.,Lloyd C.R.,Lloyd D.M.,Loveland J.E.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,Maslen G.L.,Matthews L.,McCann O.T.,McLaren S.J.,McLay K.,McMurray A.,Moore M.J.F.,Mullikin J.C.,Niblett D.,Nickerson T.,Novik K.L.,Oliver K.,Overton-Larty E.K.,Parker A.,Patel R.,Pearce A.V.,Peck A.I.,Phillimore B.J.C.T.,Phillips S.,Plumb R.W.,Porter K.M.,Ramsey Y.,Ranby S.A.,Rice C.M.,Ross M.T.,Searle S.M.,Sehra H.K.,Sheridan E.,Skuce C.D.,Smith S.,Smith M.,Spraggon L.,Squares S.L.,Steward C.A.,Sycamore N.,Tamlyn-Hall G.,Tester J.,Theaker A.J.,Thomas D.W.,Thorpe A.,Tracey A.,Tromans A.,Tubby B.,Wall M.,Wallis J.M.,West A.P.,White S.S.,Whitehead S.L.,Whittaker H.,Wild A.,Willey D.J.,Wilmer T.E.,Wood J.M.,Wray P.W.,Wyatt J.C.,Young L.,Younger R.M.,Bentley D.R.,Coulson A.,Durbin R.M.,Hubbard T.,Sulston J.E.,Dunham I.,Rogers J.,Beck S.
The DNA sequence and analysis of human chromosome 6.
Nature
425
805-811
2003
109965
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
109966
Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.
The full-ORF clone resource of the German cDNA consortium.
BMC Genomics
8
399-399
2007
109967
Song H.Y.,Rothe M.,Goeddel D.V.
The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.
Proc. Natl. Acad. Sci. U.S.A.
93
6721-6725
1996
109968
De Valck D.,Heyninck K.,Van Criekinge W.,Vandenabeele P.,Fiers W.,Beyaert R.
A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins.
Biochem. Biophys. Res. Commun.
238
590-594
1997
109969
Eliopoulos A.G.,Blake S.M.,Floettmann J.E.,Rowe M.,Young L.S.
Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C-terminus via a mechanism involving TRADD and TRAF2.
J. Virol.
73
1023-1035
1999
109970
de Valck D.,Jin D.-Y.,Heyninck K.,van de Craen M.,Contreras R.,Fiers W.,Jeang K.-T.,Beyaert R.
The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.
Oncogene
18
4182-4190
1999
109971
Evans P.C.,Taylor E.R.,Coadwell J.,Heyninck K.,Beyaert R.,Kilshaw P.J.
Isolation and characterization of two novel A20-like proteins.
Biochem. J.
357
617-623
2001
109972
Evans P.C.,Ovaa H.,Hamon M.,Kilshaw P.J.,Hamm S.,Bauer S.,Ploegh H.L.,Smith T.S.
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity.
Biochem. J.
378
727-734
2004
109973
Wertz I.E.,O'Rourke K.M.,Zhou H.,Eby M.,Aravind L.,Seshagiri S.,Wu P.,Wiesmann C.,Baker R.,Boone D.L.,Ma A.,Koonin E.V.,Dixit V.M.
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.
Nature
430
694-699
2004
109974
Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Cell
127
635-648
2006
109975
Mauro C.,Pacifico F.,Lavorgna A.,Mellone S.,Iannetti A.,Acquaviva R.,Formisano S.,Vito P.,Leonardi A.
ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB.
J. Biol. Chem.
281
18482-18488
2006
109976
Coornaert B.,Baens M.,Heyninck K.,Bekaert T.,Haegman M.,Staal J.,Sun L.,Chen Z.J.,Marynen P.,Beyaert R.
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20.
Nat. Immunol.
9
263-271
2008
109977
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
109978
Li L.,Soetandyo N.,Wang Q.,Ye Y.
The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation.
Biochim. Biophys. Acta
1793
346-353
2009
109979
Shembade N.,Parvatiyar K.,Harhaj N.S.,Harhaj E.W.
The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.
EMBO J.
28
513-522
2009
109980
Duwel M.,Welteke V.,Oeckinghaus A.,Baens M.,Kloo B.,Ferch U.,Darnay B.G.,Ruland J.,Marynen P.,Krappmann D.
A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.
J. Immunol.
182
7718-7728
2009
109981
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
109982
Malinverni C.,Unterreiner A.,Staal J.,Demeyer A.,Galaup M.,Luyten M.,Beyaert R.,Bornancin F.
Cleavage by MALT1 induces cytosolic release of A20.
Biochem. Biophys. Res. Commun.
400
543-547
2010
109983
Skaug B.,Chen J.,Du F.,He J.,Ma A.,Chen Z.J.
Direct, noncatalytic mechanism of IKK inhibition by A20.
Mol. Cell
44
559-571
2011
109984
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
109985
Mevissen T.E.,Hospenthal M.K.,Geurink P.P.,Elliott P.R.,Akutsu M.,Arnaudo N.,Ekkebus R.,Kulathu Y.,Wauer T.,El Oualid F.,Freund S.M.,Ovaa H.,Komander D.
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.
Cell
154
169-184
2013
109986
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
109987
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
109988
Zhou Q.,Wang H.,Schwartz D.M.,Stoffels M.,Park Y.H.,Zhang Y.,Yang D.,Demirkaya E.,Takeuchi M.,Tsai W.L.,Lyons J.J.,Yu X.,Ouyang C.,Chen C.,Chin D.T.,Zaal K.,Chandrasekharappa S.C.,P Hanson E.,Yu Z.,Mullikin J.C.,Hasni S.A.,Wertz I.E.,Ombrello A.K.,Stone D.L.,Hoffmann P.,Jones A.,Barham B.K.,Leavis H.L.,van Royen-Kerkof A.,Sibley C.,Batu E.D.,Guel A.,Siegel R.M.,Boehm M.,Milner J.D.,Ozen S.,Gadina M.,Chae J.,Laxer R.M.,Kastner D.L.,Aksentijevich I.
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease.
Nat. Genet.
48
67-73
2016
109990
Komander D.,Barford D.
Structure of the A20 OTU domain and mechanistic insights into deubiquitination.
Biochem. J.
409
77-85
2008
109991
Lin S.C.,Chung J.Y.,Lamothe B.,Rajashankar K.,Lu M.,Lo Y.C.,Lam A.Y.,Darnay B.G.,Wu H.
Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20.
J. Mol. Biol.
376
526-540
2008
109992
Bosanac I.,Wertz I.E.,Pan B.,Yu C.,Kusam S.,Lam C.,Phu L.,Phung Q.,Maurer B.,Arnott D.,Kirkpatrick D.S.,Dixit V.M.,Hymowitz S.G.
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-kappaB signaling.
Mol. Cell
40
548-557
2010
109993
Mevissen T.E.,Kulathu Y.,Mulder M.P.,Geurink P.P.,Maslen S.L.,Gersch M.,Elliott P.R.,Burke J.E.,van Tol B.D.,Akutsu M.,El Oualid F.,Kawasaki M.,Freund S.M.,Ovaa H.,Komander D.
Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature
538
402-405
2016
109994
Shigemura T.,Kaneko N.,Kobayashi N.,Kobayashi K.,Takeuchi Y.,Nakano N.,Masumoto J.,Agematsu K.
Novel heterozygous C243Y A20/TNFAIP3 gene mutation is responsible for chronic inflammation in autosomal-dominant Behcet's disease.
RMD Open
2
0-0
2016
