Sequence of TCS1_CAMSI
EC Number:2.1.1.160
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
S-adenosyl-L-methionine + 1,7-dimethylxanthine = S-adenosyl-L-homocysteine + 1,3,7-trimethylxanthine
General information:
Sequence
0 MELATAGKVN EVLFMNRGEG ESSYAQNSSF TQQVASMAQP ALENAVETLF SRDFHLQALN
60 AADLGCAAGP NTFAVISTIK RMMEKKCREL NCQTLELQVY LNDLFGNDFN TLFKGLSSEV
120 IGNKCEEVPC YVMGVPGSFH GRLFPRNSLH LVHSSYSVHW LTQAPKGLTS REGLALNKGK
180 IYISKTSPPV VREAYLSQFH EDFTMFLNAR SQEVVPNGCM VLILRGRQCS DPSDMQSCFT
240 WELLAMAIAE LVSQGLIDED KLDTFNIPSY FASLEEVKDI VERDGSFTID HIEGFDLDSV
300 EMQENDKWVR GEKFTKVVRA FTEPIISNQF GPEIMDKLYD KFTHIVVSDL EAKLPKTTSI
360 ILVLSKIDG
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
1199729
Kato M.,Mizuno K.,Crozier A.,Fujimura T.,Ashihara H.
Caffeine synthase gene from tea leaves.
Nature
406
956-957
2000
1199732
Kato M.,Mizuno K.,Fujimura T.,Iwama M.,Irie M.,Crozier A.,Ashihara H.
Purification and characterization of caffeine synthase from tea leaves.
Plant Physiol.
120
579-586
1999
1199733
Mizuno K.,Okuda A.,Kato M.,Yoneyama N.,Tanaka H.,Ashihara H.,Fujimura T.
Isolation of a new dual-functional caffeine synthase gene encoding an enzyme for the conversion of 7-methylxanthine to caffeine from coffee (Coffea arabica L.).
FEBS Lett.
534
75-81
2003
1199734
Mizuno K.,Kato M.,Irino F.,Yoneyama N.,Fujimura T.,Ashihara H.
The first committed step reaction of caffeine biosynthesis: 7-methylxanthosine synthase is closely homologous to caffeine synthases in coffee (Coffea arabica L.).
FEBS Lett.
547
56-60
2003
1199735
Yoneyama N.,Morimoto H.,Ye C.-X.,Ashihara H.,Mizuno K.,Kato M.
Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme.
Mol. Genet. Genomics
275
125-135
2006
1199736
Ashihara H.,Sano H.,Crozier A.
Caffeine and related purine alkaloids: biosynthesis, catabolism, function and genetic engineering.
Phytochemistry
69
841-856
2008
1199737
Kato M.,Kitao N.,Ishida M.,Morimoto H.,Irino F.,Mizuno K.
Expression for caffeine biosynthesis and related enzymes in Camellia sinensis.
Z. Naturforsch. C Biosci.
65
245-256
2010
1199738
Jin L.,Bhuiya M.W.,Li M.,Liu X.,Han J.,Deng W.,Wang M.,Yu O.,Zhang Z.
Metabolic engineering of Saccharomyces cerevisiae for caffeine and theobromine production.
PLoS ONE
9
e105368-e105368
2014
1199739
Jin J.-Q.,Yao M.-Z.,Ma C.-L.,Ma J.-Q.,Chen L.
Natural allelic variations of TCS1 play a crucial role in caffeine biosynthesis of tea plant and its related species.
Plant Physiol. Biochem.
100
18-26
2016
1199740
Jin J.-Q.,Yao M.-Z.,Ma C.-L.,Ma J.-Q.,Chen L.
Association mapping of caffeine content with TCS1 in tea plant and its related species.
Plant Physiol. Biochem.
105
251-259
2016
1199741
Jin J.Q.,Chai Y.F.,Liu Y.F.,Zhang J.,Yao M.Z.,Chen L.
Hongyacha, a naturally caffeine-free tea plant from Fujian, China.
J. Agric. Food Chem.
66
11311-11319
2018
